Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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BT-549 | AZD8055 | 3 | 72 | sigmoid | sigmoid | BT549 AZD8055 0 3 72 | 8 | 1.757 | 0.0178 | 0.159 | 0.59 | 0.0122 | 0.145 | 0.913 | 0.942 | 0.000193 | NA | 0.0479 | 0.383 | 0.555 | 0.00973 | 0.372 | 0.854 | 0.954 | 9.74e-05 | NA |
Hs 578T | Pictilisib | 3 | sigmoid | sigmoid | Hs578T pictilisib 3 | 8 | 2.911 | 2.33 | 0.471 | 0.168 | 0.364 | 0.403 | 0.883 | 0.996 | 5.24e-08 | NA | 0.97 | 0.409 | 0.794 | 0.228 | 0.374 | 0.952 | 0.996 | 5.98e-08 | NA | |
BT-20 | WYE-125132 | 1 | 72 | sigmoid | sigmoid | BT20 WYE-132 0 1 72 | 8 | 2.067 | 0.0893 | 0.289 | 0.402 | 0.0435 | 0.256 | 1.0 | 0.987 | 2.28e-06 | NA | 0.154 | 0.403 | 0.647 | 0.0353 | 0.375 | 0.941 | 0.985 | 3.56e-06 | NA |
HCC38 | WYE-125132 | 1 | 72 | sigmoid | sigmoid | HCC38 WYE-132 0 1 72 | 8 | 1.708 | 0.0604 | 0.142 | 0.447 | 0.0481 | 0.134 | 1.36 | 0.997 | 3.43e-08 | NA | 0.115 | 0.384 | 0.669 | 0.0413 | 0.381 | 1.4 | 0.996 | 6.46e-08 | NA |
Hs 578T | Pictilisib | 2 | sigmoid | sigmoid | Hs578T pictilisib 2 | 8 | 2.512 | 1.93 | 0.45 | 0.194 | 0.4 | 0.333 | 0.696 | 0.98 | 8e-06 | NA | 1.58 | 0.446 | 0.787 | 0.231 | 0.381 | 0.746 | 0.974 | 1.74e-05 | NA | |
BT-549 | Pictilisib | 1 | 72 | sigmoid | sigmoid | BT549 pictilisib 0 1 72 | 8 | 1.772 | 2.08 | 0.415 | 0.117 | 1.42 | 0.154 | 0.959 | 0.987 | 2.26e-06 | NA | 5.12 | 0.541 | 0.904 | 1.06 | 0.396 | 0.995 | 0.985 | 3.49e-06 | NA |
HCC38 | Pictilisib | 3 | 72 | sigmoid | sigmoid | HCC38 pictilisib 0 3 72 | 8 | 1.420 | 3.12 | 0.499 | 0.129 | 2.45 | 0.0818 | 0.738 | 0.976 | 1.33e-05 | NA | 20.5 | 0.664 | 0.911 | 2.24 | 0.401 | 0.731 | 0.974 | 1.7e-05 | NA |
HCC1806 | WYE-125132 | 2 | 72 | sigmoid | sigmoid | HCC1806 WYE-132 0 2 72 | 8 | 2.874 | 0.872 | 0.479 | 0.284 | 0.045 | 0.464 | 0.883 | 0.997 | 3.66e-08 | NA | 0.226 | 0.42 | 0.663 | 0.0335 | 0.402 | 0.855 | 0.996 | 8.79e-08 | NA |
HCC1806 | WYE-125132 | 3 | 72 | sigmoid | sigmoid | HCC1806 WYE-132 0 3 72 | 8 | 3.242 | Inf | 0.531 | 0.255 | 0.0458 | 0.517 | 0.885 | 0.997 | 3.48e-08 | NA | 0.226 | 0.42 | 0.663 | 0.0335 | 0.402 | 0.855 | 0.996 | 8.79e-08 | NA |
HCC1806 | WYE-125132 | 1 | 72 | sigmoid | sigmoid | HCC1806 WYE-132 0 1 72 | 8 | 2.790 | 0.603 | 0.466 | 0.292 | 0.0448 | 0.45 | 0.883 | 0.997 | 3.72e-08 | NA | 0.226 | 0.42 | 0.663 | 0.0335 | 0.402 | 0.855 | 0.996 | 8.79e-08 | NA |
BT-549 | AZD-6482 | 1 | 72 | sigmoid | sigmoid | BT549 AZD6482 0 1 72 | 8 | 1.798 | 27.5 | 0.671 | 0.115 | 4.1 | 0.299 | 0.478 | 0.992 | 4.23e-07 | NA | 164.0 | 0.723 | 0.901 | 4.18 | 0.408 | 0.461 | 0.992 | 5.34e-07 | NA |
Hs 578T | AS605240 | 1 | sigmoid | sigmoid | Hs578T AS-605240 1 | 8 | 2.015 | 0.758 | 0.341 | 0.212 | 0.333 | 0.265 | 0.921 | 0.991 | 7.83e-07 | NA | 1.42 | 0.447 | 0.811 | 0.246 | 0.408 | 0.964 | 0.989 | 1.51e-06 | NA | |
HCC38 | Trametinib | 3 | 72 | sigmoid | sigmoid | HCC38 trametinib 0 3 72 | 8 | 1.486 | 0.229 | 0.132 | 0.342 | 0.19 | 0.108 | 1.3 | 0.969 | 2.85e-05 | NA | 0.689 | 0.429 | 0.766 | 0.176 | 0.409 | 1.25 | 0.962 | 5.31e-05 | NA |
HCC38 | AS605240 | 2 | 72 | sigmoid | sigmoid | HCC38 AS-605240 0 2 72 | 8 | 2.200 | 17.4 | 0.642 | 0.114 | 4.07 | 0.256 | 0.493 | 0.936 | 0.000265 | NA | 46.2 | 0.648 | 0.882 | 1.68 | 0.411 | 0.522 | 0.929 | 0.000356 | NA |
BT-549 | BX-912 | 1 | 72 | sigmoid | sigmoid | BT549 BX-912 0 1 72 | 8 | 1.839 | 0.909 | 0.247 | 0.157 | 0.742 | 0.24 | 3.23 | 0.992 | 5.95e-07 | NA | 1.2 | 0.419 | 0.872 | 0.698 | 0.415 | 3.25 | 0.988 | 1.54e-06 | NA |
Hs 578T | Pictilisib | 1 | sigmoid | sigmoid | Hs578T pictilisib 1 | 8 | 2.048 | 0.482 | 0.341 | 0.267 | 0.162 | 0.295 | 0.819 | 0.998 | 8.97e-09 | NA | 0.981 | 0.441 | 0.759 | 0.12 | 0.416 | 0.847 | 0.998 | 6.97e-09 | NA | |
HCC70 | Dactolisib | 2 | 72 | sigmoid | sigmoid | HCC70 dactolisib 0 2 72 | 8 | 1.677 | 0.312 | 0.238 | 0.341 | 0.195 | 0.103 | 0.493 | 0.954 | 9.66e-05 | NA | 2.24 | 0.447 | 0.738 | 0.0858 | 0.419 | 0.56 | 0.954 | 9.8e-05 | NA |
Hs 578T | Everolimus | 2 | sigmoid | sigmoid | Hs578T everolimus 2 | 8 | 2.550 | 3210000000.0 | 0.626 | 0.335 | 0.000205 | 0.476 | 0.1 | 0.791 | 0.00913 | NA | 18938.0 | 0.59 | 0.627 | 0.000153 | 0.422 | 0.1 | 0.745 | 0.0166 | NA | |
HCC38 | ZSTK474 | 1 | 72 | sigmoid | sigmoid | HCC38 ZSTK474 0 1 72 | 8 | 1.742 | 2.47 | 0.456 | 0.132 | 1.34 | 0.202 | 0.843 | 0.991 | 7.12e-07 | NA | 9.02 | 0.575 | 0.893 | 1.0 | 0.426 | 0.869 | 0.99 | 1.01e-06 | NA |
HCC70 | MK2206 | 3 | 72 | sigmoid | sigmoid | HCC70 MK-2206 0 3 72 | 8 | 2.378 | 1.43 | 0.423 | 0.139 | 0.451 | 0.39 | 1.31 | 0.983 | 5.28e-06 | NA | 1.47 | 0.445 | 0.859 | 0.349 | 0.437 | 1.44 | 0.977 | 1.2e-05 | NA |
HCC70 | MK2206 | 2 | 72 | sigmoid | sigmoid | HCC70 MK-2206 0 2 72 | 8 | 1.690 | 0.446 | 0.244 | 0.2 | 0.301 | 0.226 | 1.53 | 0.973 | 1.92e-05 | NA | 1.03 | 0.448 | 0.851 | 0.266 | 0.44 | 1.56 | 0.965 | 4.11e-05 | NA |
BT-549 | Everolimus | 1 | 72 | sigmoid | sigmoid | BT549 everolimus 0 1 72 | 8 | 1.772 | 5.64 | 0.503 | 0.444 | 1e-05 | 0.367 | 0.1 | 0.911 | 0.000706 | NA | 437200.0 | 0.603 | 0.641 | 0.000146 | 0.444 | 0.1 | 0.858 | 0.00286 | NA |
BT-549 | Sirolimus | 1 | 72 | sigmoid | sigmoid | BT549 rapamycin 0 1 72 | 8 | 1.817 | 3.62 | 0.51 | 0.438 | 0.000148 | 0.318 | 0.1 | 0.87 | 0.00218 | NA | 506850.0 | 0.6 | 0.638 | 8.82e-05 | 0.447 | 0.1 | 0.8 | 0.00802 | NA |
BT-549 | BX-912 | 2 | 72 | sigmoid | sigmoid | BT549 BX-912 0 2 72 | 8 | 1.948 | 1.04 | 0.33 | 0.126 | 0.84 | 0.329 | 5.0 | 0.99 | 1.01e-06 | NA | 1.28 | 0.452 | 0.892 | 0.808 | 0.451 | 5.0 | 0.987 | 2.4e-06 | NA |
Hs 578T | KIN001-244 | 2 | sigmoid | sigmoid | Hs578T KIN001-244 2 | 8 | 2.505 | Inf | 0.819 | 0.0357 | 4.8 | 0.531 | 1.14 | 0.891 | 0.0013 | NA | 44.3 | 0.788 | 0.957 | 4.79 | 0.457 | 1.1 | 0.878 | 0.0018 | NA |