Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line	Drug name	Experimental replicate	Timepoint	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared sigmoid fit (GR values)	P-value sigmoid fit (GR values)	R-squared flat fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared sigmoid fit (relative cell counts)	P-value sigmoid fit (relative cell counts)	R-squared flat fit (relative cell counts)
Hs 578T	AS605240	1		sigmoid	sigmoid	Hs578T AS-605240 1	8	2.015	0.758	0.341	0.212	0.333	0.265	0.921	0.991	7.83e-07	NA	1.42	0.447	0.811	0.246	0.408	0.964	0.989	1.51e-06	NA
HCC70	MK2206	2	72	sigmoid	sigmoid	HCC70 MK-2206 0 2 72	8	1.690	0.446	0.244	0.2	0.301	0.226	1.53	0.973	1.92e-05	NA	1.03	0.448	0.851	0.266	0.44	1.56	0.965	4.11e-05	NA
HCC70	GDC-0980	1	72	sigmoid	sigmoid	HCC70 apitolisib 0 1 72	8	1.350	0.211	-0.312	0.362	0.339	-0.362	1.15	0.985	3.24e-06	NA	0.441	0.237	0.779	0.266	0.236	1.26	0.985	3.31e-06	NA
BT-20	PI103	3	72	sigmoid	sigmoid	BT20 PI-103 0 3 72	8	2.496	0.373	0.0139	0.282	0.387	-0.0286	1.52	0.994	1.99e-07	NA	0.359	0.183	0.735	0.279	0.162	1.56	0.988	1.71e-06	NA
HCC70	GDC-0980	3	72	sigmoid	sigmoid	HCC70 apitolisib 0 3 72	8	2.423	0.623	0.206	0.211	0.509	0.0878	0.959	0.986	2.55e-06	NA	0.568	0.293	0.792	0.283	0.266	1.09	0.981	6.41e-06	NA
HCC70	GDC-0980	2	72	sigmoid	sigmoid	HCC70 apitolisib 0 2 72	8	1.676	0.318	-0.0849	0.284	0.451	-0.205	0.983	0.976	1.34e-05	NA	0.536	0.27	0.795	0.285	0.252	1.11	0.972	2.28e-05	NA
HCC38	TGX221	1	72	sigmoid	sigmoid	HCC38 TGX-221 0 1 72	8	1.724	Inf	0.938	0.0116	0.289	0.941	5.0	0.676	0.0342	NA	Inf	0.947	0.99	0.289	0.949	5.0	0.672	0.0354	NA
BT-20	ZSTK474	2	72	sigmoid	sigmoid	BT20 ZSTK474 0 2 72	8	1.787	0.286	-0.19	0.347	0.373	-0.234	1.46	0.992	4.53e-07	NA	0.391	0.199	0.743	0.29	0.184	1.55	0.988	1.84e-06	NA
HCC70	TGX221	3	72	sigmoid	sigmoid	HCC70 TGX-221 0 3 72	8	2.459	Inf	0.7	0.0886	0.338	0.675	1.11	0.971	2.48e-05	NA	Inf	0.671	0.9	0.295	0.648	1.13	0.966	3.94e-05	NA
BT-549	TGX221	1	72	sigmoid	sigmoid	BT549 TGX-221 0 1 72	8	1.826	Inf	0.821	0.0771	0.297	0.777	0.632	0.868	0.00232	NA	Inf	0.842	0.931	0.313	0.799	0.603	0.863	0.00255	NA
HCC38	AZD-6482	3	72	sigmoid	sigmoid	HCC38 AZD6482 0 3 72	8	1.420	Inf	0.821	0.0615	0.324	0.826	5.0	0.849	0.00342	NA	Inf	0.875	0.957	0.323	0.879	5.0	0.846	0.00367	NA
Hs 578T	ZSTK474	3		sigmoid	sigmoid	Hs578T ZSTK474 3	8	2.863	0.913	0.31	0.201	0.613	0.143	0.846	0.999	6.21e-10	NA	0.607	0.298	0.767	0.329	0.211	0.895	0.999	1.43e-09	NA
HCC70	AS605240	3	72	sigmoid	sigmoid	HCC70 AS-605240 0 3 72	8	2.447	Inf	0.58	0.112	0.427	0.549	1.18	0.985	3.24e-06	NA	Inf	0.562	0.877	0.345	0.544	1.24	0.982	6.14e-06	NA
HCC70	MK2206	3	72	sigmoid	sigmoid	HCC70 MK-2206 0 3 72	8	2.378	1.43	0.423	0.139	0.451	0.39	1.31	0.983	5.28e-06	NA	1.47	0.445	0.859	0.349	0.437	1.44	0.977	1.2e-05	NA
HCC38	GDC-0980	3	72	sigmoid	sigmoid	HCC38 apitolisib 0 3 72	8	1.437	0.371	-0.0189	0.29	0.513	-0.179	0.946	0.993	3.35e-07	NA	0.96	0.359	0.808	0.393	0.295	0.998	0.993	3.51e-07	NA
HCC38	AS605240	1	72	sigmoid	sigmoid	HCC38 AS-605240 0 1 72	8	1.744	Inf	0.734	0.0803	0.448	0.691	0.881	0.969	2.92e-05	NA	Inf	0.78	0.932	0.405	0.748	0.895	0.967	3.48e-05	NA
BT-20	ZSTK474	3	72	sigmoid	sigmoid	BT20 ZSTK474 0 3 72	8	2.609	0.457	-0.00222	0.296	0.783	-0.31	0.895	0.982	5.76e-06	NA	0.422	0.163	0.702	0.422	0.0	0.82	0.971	2.52e-05	NA
BT-549	ZSTK474	1	72	sigmoid	sigmoid	BT549 ZSTK474 0 1 72	8	1.861	0.58	0.213	0.256	0.583	-0.00205	0.771	0.992	5.43e-07	NA	1.12	0.394	0.788	0.428	0.261	0.767	0.989	1.49e-06	NA
HCC38	BX-912	3	72	sigmoid	sigmoid	HCC38 BX-912 0 3 72	8	1.454	0.422	-0.428	0.365	0.478	-0.433	5.0	0.993	4.02e-07	NA	0.496	0.162	0.778	0.46	0.159	5.0	0.989	1.24e-06	NA
HCC1806	GDC-0980	3	72	sigmoid	sigmoid	HCC1806 apitolisib 0 3 72	8	3.149	1.8	0.418	0.132	0.77	0.31	1.14	0.995	1.41e-07	NA	0.947	0.339	0.832	0.475	0.292	1.27	0.993	2.95e-07	NA
HCC1806	GDC-0980	2	72	sigmoid	sigmoid	HCC1806 apitolisib 0 2 72	8	2.781	1.32	0.355	0.148	0.746	0.241	1.15	0.995	1.49e-07	NA	0.947	0.339	0.832	0.475	0.292	1.27	0.993	2.95e-07	NA
HCC1806	GDC-0980	1	72	sigmoid	sigmoid	HCC1806 apitolisib 0 1 72	8	2.696	1.24	0.339	0.152	0.739	0.223	1.15	0.995	1.52e-07	NA	0.947	0.339	0.832	0.475	0.292	1.27	0.993	2.95e-07	NA
HCC70	Pictilisib	1	72	sigmoid	sigmoid	HCC70 pictilisib 0 1 72	8	1.409	0.408	-0.099	0.284	0.578	-0.245	1.14	0.996	7.62e-08	NA	0.888	0.325	0.816	0.477	0.261	1.19	0.995	1.2e-07	NA
BT-20	Buparlisib	2	72	sigmoid	sigmoid	BT20 buparlisib 0 2 72	8	1.743	0.334	-0.45	0.391	0.844	-0.82	1.05	0.972	2.21e-05	NA	0.487	0.105	0.718	0.487	0.0	1.12	0.948	0.000142	NA
HCC38	PI103	2	72	sigmoid	sigmoid	HCC38 PI-103 0 2 72	8	2.094	0.856	0.226	0.167	0.672	0.135	1.3	0.986	2.7e-06	NA	1.04	0.359	0.851	0.488	0.33	1.43	0.981	6.52e-06	NA

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HMS LINCS Project

Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)