Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-20 Trametinib 3 72
sigmoid
sigmoid
BT20 trametinib 0 3 72
 8 2.539
Inf
0.64
0.208
0.104
0.541
0.392
0.967
3.69e-05
NA
Inf
0.604
0.761
0.0656
0.513
0.391
0.964
4.56e-05
NA
HCC38 GDC-0980 1 72
sigmoid
sigmoid
HCC38 apitolisib 0 1 72
 8 1.777
0.317
0.114
0.305
0.295
0.0315
0.91
0.99
9.47e-07
NA
0.623
0.354
0.761
0.219
0.315
0.951
0.989
1.26e-06
NA
BT-20 Buparlisib 3 72
sigmoid
sigmoid
BT20 buparlisib 0 3 72
 8 2.529
0.629
-0.303
0.26
1.06
-0.565
1.46
0.994
2.13e-07
NA
0.603
0.0696
0.764
0.603
0.0
1.52
0.984
4.36e-06
NA
Hs 578T ZSTK474 1
sigmoid
sigmoid
Hs578T ZSTK474 1
 8 1.968
0.325
0.137
0.279
0.265
0.0807
0.854
0.973
1.94e-05
NA
0.471
0.329
0.764
0.149
0.343
1.01
0.972
2.27e-05
NA
BT-20 PIK-93 2 72
sigmoid
sigmoid
BT20 PIK-93 0 2 72
 8 1.798
0.792
0.155
0.286
14.1
-1.0
0.382
0.81
0.00687
NA
2.8
0.373
0.764
2.8
0.0
0.344
0.77
0.0121
NA
HCC1806 Everolimus 1 72
sigmoid
sigmoid
HCC1806 everolimus 0 1 72
 8 2.786
Inf
0.784
0.183
0.000282
0.748
0.187
0.86
0.00277
NA
Inf
0.727
0.765
0.00022
0.729
0.377
0.879
0.00177
NA
HCC1806 Everolimus 3 72
sigmoid
sigmoid
HCC1806 everolimus 0 3 72
 8 3.239
Inf
0.813
0.159
0.000271
0.812
0.356
0.879
0.00175
NA
Inf
0.727
0.765
0.00022
0.729
0.377
0.879
0.00177
NA
HCC1806 Everolimus 2 72
sigmoid
sigmoid
HCC1806 everolimus 0 2 72
 8 2.871
Inf
0.79
0.178
0.000277
0.79
0.365
0.879
0.00176
NA
Inf
0.727
0.765
0.000222
0.728
0.374
0.879
0.00178
NA
BT-20 Buparlisib 1 72
sigmoid
sigmoid
BT20 buparlisib 0 1 72
 8 2.131
0.598
-0.394
0.285
1.19
-0.763
1.35
0.992
4.68e-07
NA
0.663
0.0784
0.766
0.663
0.0
1.49
0.981
7.06e-06
NA
HCC38 Trametinib 3 72
sigmoid
sigmoid
HCC38 trametinib 0 3 72
 8 1.486
0.229
0.132
0.342
0.19
0.108
1.3
0.969
2.85e-05
NA
0.689
0.429
0.766
0.176
0.409
1.25
0.962
5.31e-05
NA
HCC70 Everolimus 1 72
flat
flat
HCC70 everolimus 0 1 72
 8 1.366
Inf
0.569
0.354
0.0
0.569
0.01
0.623
0.0534
0.643
Inf
0.718
0.766
0.0
0.718
0.01
0.62
0.0547
0.765
Hs 578T ZSTK474 3
sigmoid
sigmoid
Hs578T ZSTK474 3
 8 2.863
0.913
0.31
0.201
0.613
0.143
0.846
0.999
6.21e-10
NA
0.607
0.298
0.767
0.329
0.211
0.895
0.999
1.43e-09
NA
BT-20 Pictilisib 3 72
sigmoid
sigmoid
BT20 pictilisib 0 3 72
 8 2.566
0.839
0.172
0.22
0.914
-0.0483
1.09
0.954
9.59e-05
NA
0.843
0.254
0.768
0.809
0.0179
0.898
0.918
0.000551
NA
BT-20 Trametinib 2 72
sigmoid
sigmoid
BT20 trametinib 0 2 72
 8 1.723
0.761
0.303
0.289
11.1
-0.768
0.347
0.965
4.13e-05
NA
2.56
0.478
0.77
2.56
0.0
0.362
0.957
8.16e-05
NA
BT-20 AZD-6482 2 72
sigmoid
sigmoid
BT20 AZD6482 0 2 72
 8 1.645
0.581
0.0253
0.303
3.86
-1.0
0.58
0.904
0.000884
NA
1.34
0.333
0.772
1.34
0.0
0.582
0.864
0.0025
NA
HCC70 MK2206 1 72
sigmoid
sigmoid
HCC70 MK-2206 0 1 72
 8 1.444
0.314
-0.0266
0.337
0.618
-0.336
0.758
0.991
6.35e-07
NA
0.925
0.353
0.775
0.521
0.172
0.737
0.99
1.08e-06
NA
BT-20 Alpelisib 3 72
sigmoid
sigmoid
BT20 alpelisib 0 3 72
 8 2.541
1.21
0.199
0.21
5.83
-1.0
0.697
0.881
0.00167
NA
1.12
0.272
0.775
1.12
0.0
0.764
0.791
0.00916
NA
BT-549 Buparlisib 3 72
sigmoid
sigmoid
BT549 buparlisib 0 3 72
 8 1.795
0.602
-0.351
0.295
1.64
-1.0
1.09
0.983
4.52e-06
NA
0.804
0.132
0.777
0.804
0.0
1.26
0.968
3.41e-05
NA
HCC38 BX-912 3 72
sigmoid
sigmoid
HCC38 BX-912 0 3 72
 8 1.454
0.422
-0.428
0.365
0.478
-0.433
5.0
0.993
4.02e-07
NA
0.496
0.162
0.778
0.46
0.159
5.0
0.989
1.24e-06
NA
HCC70 GDC-0980 1 72
sigmoid
sigmoid
HCC70 apitolisib 0 1 72
 8 1.350
0.211
-0.312
0.362
0.339
-0.362
1.15
0.985
3.24e-06
NA
0.441
0.237
0.779
0.266
0.236
1.26
0.985
3.31e-06
NA
Hs 578T Buparlisib 2
sigmoid
sigmoid
Hs578T buparlisib 2
 8 2.513
0.665
-0.42
0.251
1.61
-1.0
1.24
0.998
1.14e-08
NA
0.595
0.0445
0.779
0.595
0.0
1.36
0.994
2.48e-07
NA
Hs 578T Buparlisib 3
sigmoid
sigmoid
Hs578T buparlisib 3
 8 2.890
0.778
-0.425
0.233
1.71
-1.0
1.4
0.998
1.34e-08
NA
0.622
0.0272
0.779
0.622
0.0
1.57
0.991
8.01e-07
NA
HCC70 ZSTK474 3 72
sigmoid
sigmoid
HCC70 ZSTK474 0 3 72
 8 2.502
0.455
0.176
0.223
0.345
0.155
1.35
0.991
8.07e-07
NA
0.401
0.265
0.782
0.24
0.274
1.55
0.987
1.99e-06
NA
HCC70 Everolimus 3 72
sigmoid
sigmoid
HCC70 everolimus 0 3 72
 8 2.401
530906.0
0.749
0.195
0.072
0.603
0.1
0.706
0.0255
NA
381983.0
0.725
0.782
0.0137
0.59
0.1
0.706
0.0255
NA
HCC70 ZSTK474 1 72
sigmoid
sigmoid
HCC70 ZSTK474 0 1 72
 8 1.332
0.167
-0.265
0.366
0.201
-0.206
1.85
0.975
1.56e-05
NA
0.289
0.264
0.782
0.182
0.299
1.96
0.971
2.35e-05
NA