Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-549 Torin2 2 72
sigmoid
sigmoid
BT549 Torin2 0 2 72
 8 1.824
0.00997
-0.281
0.767
0.0212
-0.282
0.594
0.975
1.47e-05
NA
0.0177
0.155
0.438
0.00929
0.188
0.734
0.973
2.02e-05
NA
BT-549 Dactolisib 3 72
sigmoid
sigmoid
BT549 dactolisib 0 3 72
 8 1.801
0.0058
-0.00929
0.751
0.00579
0.000747
0.866
0.994
2.41e-07
NA
0.011
0.282
0.442
0.00425
0.29
0.909
0.995
1.54e-07
NA
Hs 578T Dactolisib 1
sigmoid
sigmoid
Hs578T dactolisib 1
 8 2.047
0.00952
-0.0606
0.691
0.00928
0.0117
0.91
0.977
1.27e-05
NA
0.0124
0.213
0.443
0.00621
0.259
1.06
0.985
3.61e-06
NA
HCC38 Dactolisib 2 72
sigmoid
sigmoid
HCC38 dactolisib 0 2 72
 8 2.120
0.0118
-0.0557
0.668
0.0118
-0.00134
0.785
0.98
7.61e-06
NA
0.0145
0.204
0.447
0.00701
0.245
0.927
0.988
1.88e-06
NA
BT-549 Torin2 1 72
sigmoid
sigmoid
BT549 Torin2 0 1 72
 8 1.771
0.0095
-0.218
0.756
0.0155
-0.193
0.672
0.985
3.06e-06
NA
0.0183
0.19
0.452
0.00874
0.218
0.775
0.988
1.88e-06
NA
BT-549 Torin2 3 72
sigmoid
sigmoid
BT549 Torin2 0 3 72
 8 1.613
0.00797
-0.254
0.794
0.0216
-0.338
0.517
0.98
8.52e-06
NA
0.0236
0.204
0.458
0.0104
0.191
0.585
0.976
1.3e-05
NA
HCC38 Torin2 1 72
sigmoid
sigmoid
HCC38 Torin2 0 1 72
 8 1.778
0.0133
-0.318
0.753
0.0337
-0.369
0.594
0.994
1.98e-07
NA
0.0264
0.148
0.459
0.0158
0.145
0.664
0.994
1.7e-07
NA
BT-549 Omipalisib 3 72
sigmoid
sigmoid
BT549 omipalisib 0 3 72
 8 1.777
0.0114
-0.23
0.753
0.0162
-0.178
0.879
0.988
1.64e-06
NA
0.0201
0.183
0.459
0.0112
0.208
0.924
0.991
6.53e-07
NA
BT-20 Torin1 3 72
sigmoid
sigmoid
BT20 Torin1 0 3 72
 8 2.569
0.0237
0.0343
0.572
0.0199
0.0736
0.899
0.993
2.77e-07
NA
0.0208
0.184
0.46
0.0119
0.204
0.944
0.997
2.51e-08
NA
Hs 578T Torin1 2
sigmoid
sigmoid
Hs578T Torin1 2
 8 2.548
0.0205
0.144
0.566
0.0148
0.14
1.0
0.999
3.13e-10
NA
0.0182
0.241
0.463
0.00975
0.24
1.04
0.999
6.11e-10
NA
Hs 578T Torin1 3
sigmoid
sigmoid
Hs578T Torin1 3
 8 2.860
0.0307
0.174
0.514
0.0196
0.176
0.964
0.999
2.01e-09
NA
0.0212
0.218
0.469
0.0119
0.222
1.02
0.998
1.17e-08
NA
BT-20 WYE-125132 2 72
sigmoid
sigmoid
BT20 WYE-132 0 2 72
 8 2.053
0.012
0.142
0.633
0.00936
0.072
0.621
0.909
0.000752
NA
0.0232
0.316
0.475
0.00613
0.255
0.536
0.894
0.00119
NA
BT-20 Dactolisib 1 72
sigmoid
sigmoid
BT20 dactolisib 0 1 72
 8 2.055
0.0223
-0.205
0.652
0.0609
-0.33
0.505
0.979
9.18e-06
NA
0.0305
0.15
0.475
0.0171
0.153
0.631
0.979
9.75e-06
NA
BT-20 AZD8055 2 72
sigmoid
sigmoid
BT20 AZD8055 0 2 72
 8 1.951
0.00909
0.155
0.651
0.00651
0.115
0.785
0.936
0.000258
NA
0.0185
0.343
0.477
0.00469
0.311
0.706
0.934
0.000289
NA
BT-549 Dactolisib 2 72
sigmoid
sigmoid
BT549 dactolisib 0 2 72
 8 1.889
0.00968
-0.00862
0.677
0.00884
0.0542
1.27
0.985
3.3e-06
NA
0.0134
0.266
0.48
0.00701
0.305
1.45
0.988
1.53e-06
NA
BT-549 Dactolisib 1 72
sigmoid
sigmoid
BT549 dactolisib 0 1 72
 8 1.840
0.00961
-0.00769
0.683
0.00888
0.0384
1.01
0.985
3.53e-06
NA
0.0161
0.275
0.482
0.0068
0.303
1.09
0.987
2.38e-06
NA
HCC38 Torin2 3 72
sigmoid
sigmoid
HCC38 Torin2 0 3 72
 8 1.385
0.013
-0.624
0.855
0.0547
-0.706
0.615
0.996
8.13e-08
NA
0.0407
0.0986
0.484
0.0311
0.0829
0.669
0.997
3.31e-08
NA
HCC1806 Torin2 1 72
sigmoid
sigmoid
HCC1806 Torin2 0 1 72
 8 2.759
0.0569
-0.203
0.582
0.0763
-0.234
1.3
0.996
6.76e-08
NA
0.0486
0.079
0.492
0.0442
0.0528
1.17
0.995
1.09e-07
NA
HCC1806 Torin2 2 72
sigmoid
sigmoid
HCC1806 Torin2 0 2 72
 8 2.843
0.0589
-0.181
0.57
0.0771
-0.211
1.3
0.996
6.72e-08
NA
0.0486
0.079
0.492
0.0442
0.0528
1.17
0.995
1.08e-07
NA
HCC38 Dactolisib 1 72
sigmoid
sigmoid
HCC38 dactolisib 0 1 72
 8 1.821
0.0109
-0.0403
0.672
0.0104
0.0212
0.892
0.985
3.44e-06
NA
0.0194
0.263
0.492
0.00757
0.301
0.975
0.988
1.65e-06
NA
HCC1806 Torin2 3 72
sigmoid
sigmoid
HCC1806 Torin2 0 3 72
 8 3.212
0.0678
-0.0927
0.522
0.0798
-0.12
1.32
0.996
6.56e-08
NA
0.0486
0.079
0.492
0.0442
0.0528
1.17
0.995
1.09e-07
NA
HCC38 Omipalisib 2 72
sigmoid
sigmoid
HCC38 omipalisib 0 2 72
 8 2.124
0.0404
-0.47
0.634
0.45
-1.0
0.456
0.979
9.71e-06
NA
0.0507
0.0595
0.494
0.0507
0.0
0.556
0.96
6.44e-05
NA
BT-549 Omipalisib 1 72
sigmoid
sigmoid
BT549 omipalisib 0 1 72
 8 1.789
0.0164
-0.2
0.693
0.0219
-0.149
0.887
0.986
2.66e-06
NA
0.0272
0.194
0.495
0.0148
0.228
0.993
0.991
8.42e-07
NA
HCC38 Dactolisib 3 72
sigmoid
sigmoid
HCC38 dactolisib 0 3 72
 8 1.468
0.0082
-0.197
0.778
0.0127
-0.181
0.711
0.993
3.98e-07
NA
0.0268
0.262
0.497
0.00923
0.277
0.757
0.994
2.62e-07
NA
HCC38 Omipalisib 3 72
sigmoid
sigmoid
HCC38 omipalisib 0 3 72
 8 1.446
0.0145
-0.503
0.802
0.0539
-0.597
0.6
0.993
3.08e-07
NA
0.0449
0.134
0.499
0.0308
0.107
0.644
0.993
2.98e-07
NA