Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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BT-549 | Trametinib | 3 | 72 | sigmoid | sigmoid | BT549 trametinib 0 3 72 | 8 | 1.755 | Inf | 0.553 | 0.223 | 0.107 | 0.505 | 0.899 | 0.942 | 0.000194 | NA | Inf | 0.642 | 0.817 | 0.104 | 0.595 | 0.804 | 0.938 | 0.000236 | NA |
HCC38 | BX-912 | 1 | 72 | sigmoid | sigmoid | HCC38 BX-912 0 1 72 | 8 | 1.760 | 0.529 | -0.322 | 0.274 | 0.591 | -0.322 | 4.49 | 0.999 | 1.36e-10 | NA | 0.584 | 0.149 | 0.818 | 0.541 | 0.149 | 4.63 | 0.999 | 8.39e-10 | NA |
BT-20 | AS605240 | 2 | 72 | sigmoid | sigmoid | BT20 AS-605240 0 2 72 | 8 | 1.846 | 4509270.0 | 0.729 | 0.203 | 320.0 | 0.31 | 0.101 | 0.845 | 0.00373 | NA | 4.4e+12 | 0.764 | 0.821 | 56.5 | 0.46 | 0.101 | 0.843 | 0.00388 | NA |
BT-549 | Trametinib | 2 | 72 | sigmoid | sigmoid | BT549 trametinib 0 2 72 | 8 | 1.914 | Inf | 0.602 | 0.2 | 0.0685 | 0.581 | 0.837 | 0.995 | 1.05e-07 | NA | Inf | 0.654 | 0.822 | 0.0601 | 0.638 | 0.839 | 0.995 | 1.04e-07 | NA |
HCC1806 | Trametinib | 3 | 72 | sigmoid | sigmoid | HCC1806 trametinib 0 3 72 | 8 | 3.204 | Inf | 0.822 | 0.12 | 0.00981 | 0.829 | 0.872 | 0.97 | 2.67e-05 | NA | Inf | 0.742 | 0.822 | 0.00864 | 0.752 | 0.892 | 0.97 | 2.67e-05 | NA |
HCC1806 | Trametinib | 2 | 72 | sigmoid | sigmoid | HCC1806 trametinib 0 2 72 | 8 | 2.836 | Inf | 0.8 | 0.135 | 0.00973 | 0.808 | 0.873 | 0.97 | 2.67e-05 | NA | Inf | 0.742 | 0.822 | 0.00864 | 0.752 | 0.892 | 0.97 | 2.67e-05 | NA |
HCC1806 | Trametinib | 1 | 72 | sigmoid | sigmoid | HCC1806 trametinib 0 1 72 | 8 | 2.751 | Inf | 0.795 | 0.139 | 0.00972 | 0.802 | 0.873 | 0.97 | 2.67e-05 | NA | Inf | 0.742 | 0.822 | 0.00864 | 0.752 | 0.892 | 0.97 | 2.67e-05 | NA |
HCC38 | Buparlisib | 3 | 72 | sigmoid | sigmoid | HCC38 buparlisib 0 3 72 | 8 | 1.431 | 0.674 | -0.377 | 0.272 | 1.67 | -1.0 | 1.21 | 0.991 | 6.94e-07 | NA | 1.11 | 0.188 | 0.824 | 1.11 | 0.0 | 1.32 | 0.987 | 2.46e-06 | NA |
BT-20 | Alpelisib | 1 | 72 | sigmoid | sigmoid | BT20 alpelisib 0 1 72 | 8 | 2.077 | 1.14 | 0.046 | 0.196 | 3.52 | -1.0 | 0.977 | 0.966 | 4.1e-05 | NA | 1.32 | 0.26 | 0.825 | 1.32 | 0.0 | 1.13 | 0.942 | 0.000194 | NA |
BT-549 | Trametinib | 1 | 72 | sigmoid | sigmoid | BT549 trametinib 0 1 72 | 8 | 1.812 | Inf | 0.596 | 0.202 | 0.131 | 0.523 | 0.61 | 0.959 | 6.65e-05 | NA | 28.3 | 0.664 | 0.828 | 3.47 | 0.254 | 0.337 | 0.933 | 0.000305 | NA |
Hs 578T | BX-912 | 2 | sigmoid | sigmoid | Hs578T BX-912 2 | 8 | 2.540 | 1.07 | -0.019 | 0.174 | 1.79 | -0.489 | 1.33 | 0.998 | 6.37e-09 | NA | 1.01 | 0.164 | 0.828 | 1.01 | 0.0 | 1.4 | 0.996 | 7.64e-08 | NA | |
HCC1806 | GDC-0980 | 2 | 72 | sigmoid | sigmoid | HCC1806 apitolisib 0 2 72 | 8 | 2.781 | 1.32 | 0.355 | 0.148 | 0.746 | 0.241 | 1.15 | 0.995 | 1.49e-07 | NA | 0.947 | 0.339 | 0.832 | 0.475 | 0.292 | 1.27 | 0.993 | 2.95e-07 | NA |
HCC1806 | GDC-0980 | 1 | 72 | sigmoid | sigmoid | HCC1806 apitolisib 0 1 72 | 8 | 2.696 | 1.24 | 0.339 | 0.152 | 0.739 | 0.223 | 1.15 | 0.995 | 1.52e-07 | NA | 0.947 | 0.339 | 0.832 | 0.475 | 0.292 | 1.27 | 0.993 | 2.95e-07 | NA |
HCC1806 | GDC-0980 | 3 | 72 | sigmoid | sigmoid | HCC1806 apitolisib 0 3 72 | 8 | 3.149 | 1.8 | 0.418 | 0.132 | 0.77 | 0.31 | 1.14 | 0.995 | 1.41e-07 | NA | 0.947 | 0.339 | 0.832 | 0.475 | 0.292 | 1.27 | 0.993 | 2.95e-07 | NA |
Hs 578T | AZD-6482 | 1 | sigmoid | sigmoid | Hs578T AZD6482 1 | 8 | 2.041 | 2.04 | 0.401 | 0.177 | 18.5 | -1.0 | 0.498 | 0.986 | 2.92e-06 | NA | 3.16 | 0.484 | 0.835 | 3.16 | 0.0 | 0.532 | 0.98 | 7.93e-06 | NA | |
BT-20 | Pictilisib | 1 | 72 | sigmoid | sigmoid | BT20 pictilisib 0 1 72 | 8 | 2.085 | 1.25 | 0.163 | 0.177 | 5.0 | -1.0 | 0.791 | 0.994 | 1.75e-07 | NA | 1.52 | 0.323 | 0.838 | 1.52 | 0.0 | 0.865 | 0.989 | 1.22e-06 | NA |
BT-549 | Buparlisib | 2 | 72 | sigmoid | sigmoid | BT549 buparlisib 0 2 72 | 8 | 1.913 | 0.681 | -0.306 | 0.217 | 1.08 | -0.538 | 1.59 | 0.998 | 1.31e-08 | NA | 0.821 | 0.132 | 0.838 | 0.769 | 0.0514 | 1.66 | 0.996 | 8.95e-08 | NA |
BT-549 | MK2206 | 1 | 72 | sigmoid | sigmoid | BT549 MK-2206 0 1 72 | 8 | 1.811 | Inf | 0.632 | 0.189 | 0.103 | 0.58 | 0.8 | 0.911 | 0.000695 | NA | Inf | 0.692 | 0.839 | 0.101 | 0.642 | 0.73 | 0.911 | 0.000717 | NA |
HCC38 | PI103 | 1 | 72 | sigmoid | sigmoid | HCC38 PI-103 0 1 72 | 8 | 1.782 | 0.755 | 0.222 | 0.201 | 0.601 | 0.12 | 1.2 | 0.996 | 4.45e-08 | NA | 1.39 | 0.416 | 0.839 | 0.494 | 0.359 | 1.23 | 0.995 | 1.01e-07 | NA |
Hs 578T | PIK-93 | 1 | sigmoid | sigmoid | Hs578T PIK-93 1 | 8 | 2.033 | 1.44 | 0.276 | 0.175 | 8.38 | -1.0 | 0.624 | 0.991 | 6.57e-07 | NA | 2.0 | 0.401 | 0.84 | 2.0 | 0.0 | 0.672 | 0.99 | 9.72e-07 | NA | |
HCC70 | TGX221 | 1 | 72 | sigmoid | sigmoid | HCC70 TGX-221 0 1 72 | 8 | 1.381 | 0.539 | 0.344 | 0.244 | 0.245 | 0.278 | 1.03 | 0.986 | 2.58e-06 | NA | Inf | 0.578 | 0.84 | 0.229 | 0.536 | 1.02 | 0.986 | 2.87e-06 | NA |
Hs 578T | MK2206 | 1 | sigmoid | sigmoid | Hs578T MK-2206 1 | 8 | 2.039 | Inf | 0.608 | 0.165 | 0.087 | 0.665 | 2.09 | 0.9 | 0.00101 | NA | Inf | 0.641 | 0.845 | 0.0803 | 0.689 | 1.9 | 0.908 | 0.000775 | NA | |
BT-20 | AZD-6482 | 1 | 72 | sigmoid | sigmoid | BT20 AZD6482 0 1 72 | 8 | 2.043 | 1.34 | 0.182 | 0.173 | 3.83 | -0.782 | 0.893 | 0.982 | 5.6e-06 | NA | 1.65 | 0.342 | 0.845 | 1.65 | 0.0 | 0.977 | 0.972 | 2.09e-05 | NA |
Hs 578T | Alpelisib | 2 | flat | flat | Hs578T alpelisib 2 | 8 | 2.513 | Inf | 0.668 | 0.131 | 0.0 | 0.668 | 0.01 | 0.599 | 0.0647 | 0.856 | Inf | 0.634 | 0.847 | 0.0 | 0.634 | 0.01 | 0.541 | 0.0969 | 0.833 | |
Hs 578T | MK2206 | 2 | sigmoid | sigmoid | Hs578T MK-2206 2 | 8 | 2.530 | Inf | 0.664 | 0.131 | 0.0699 | 0.752 | 1.34 | 0.75 | 0.0156 | NA | Inf | 0.628 | 0.848 | 0.0616 | 0.717 | 1.21 | 0.767 | 0.0126 | NA |