Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T MK2206 1
sigmoid
sigmoid
Hs578T MK-2206 1
 8 2.039
Inf
0.608
0.165
0.087
0.665
2.09
0.9
0.00101
NA
Inf
0.641
0.845
0.0803
0.689
1.9
0.908
0.000775
NA
HCC1806 Sirolimus 3 72
sigmoid
sigmoid
HCC1806 rapamycin 0 3 72
 8 3.249
0.223
0.805
0.162
0.000183
0.746
0.1
0.663
0.0382
NA
1.05
0.717
0.76
1e-05
0.657
0.1
0.68
0.0328
NA
HCC70 Buparlisib 2 72
sigmoid
sigmoid
HCC70 buparlisib 0 2 72
 8 1.724
0.861
-0.272
0.162
1.33
-0.556
1.71
0.989
1.21e-06
NA
1.12
0.175
0.888
1.03
0.0639
1.76
0.982
5.47e-06
NA
BT-20 PI103 1 72
sigmoid
sigmoid
BT20 PI-103 0 1 72
 8 1.924
0.646
-0.0114
0.16
0.659
-0.0268
2.6
0.978
1.1e-05
NA
0.753
0.258
0.883
0.579
0.252
2.68
0.964
4.79e-05
NA
HCC70 AS605240 1 72
sigmoid
sigmoid
HCC70 AS-605240 0 1 72
 8 1.387
10.4
0.487
0.159
0.247
0.497
1.34
0.963
5.14e-05
NA
Inf
0.663
0.894
0.23
0.672
1.39
0.961
6.01e-05
NA
HCC1806 Everolimus 3 72
sigmoid
sigmoid
HCC1806 everolimus 0 3 72
 8 3.239
Inf
0.813
0.159
0.000271
0.812
0.356
0.879
0.00175
NA
Inf
0.727
0.765
0.00022
0.729
0.377
0.879
0.00177
NA
BT-549 BX-912 1 72
sigmoid
sigmoid
BT549 BX-912 0 1 72
 8 1.839
0.909
0.247
0.157
0.742
0.24
3.23
0.992
5.95e-07
NA
1.2
0.419
0.872
0.698
0.415
3.25
0.988
1.54e-06
NA
HCC1806 GDC-0980 1 72
sigmoid
sigmoid
HCC1806 apitolisib 0 1 72
 8 2.696
1.24
0.339
0.152
0.739
0.223
1.15
0.995
1.52e-07
NA
0.947
0.339
0.832
0.475
0.292
1.27
0.993
2.95e-07
NA
HCC70 PI103 2 72
sigmoid
sigmoid
HCC70 PI-103 0 2 72
 8 1.739
1.19
0.0238
0.151
2.67
-0.766
1.15
0.997
2.59e-08
NA
1.68
0.312
0.885
1.68
0.0
1.21
0.996
6.86e-08
NA
HCC1806 GDC-0980 2 72
sigmoid
sigmoid
HCC1806 apitolisib 0 2 72
 8 2.781
1.32
0.355
0.148
0.746
0.241
1.15
0.995
1.49e-07
NA
0.947
0.339
0.832
0.475
0.292
1.27
0.993
2.95e-07
NA
HCC38 ZSTK474 3 72
sigmoid
sigmoid
HCC38 ZSTK474 0 3 72
 8 1.458
2.06
0.398
0.146
5.06
-0.41
0.665
0.989
1.23e-06
NA
6.44
0.593
0.898
3.35
0.179
0.678
0.988
1.64e-06
NA
HCC1806 BX-912 1 72
sigmoid
sigmoid
HCC1806 BX-912 0 1 72
 8 2.740
0.971
0.14
0.143
0.885
0.121
2.99
0.998
3.45e-09
NA
0.894
0.214
0.853
0.753
0.205
3.07
0.997
2.86e-08
NA
HCC1806 BX-912 2 72
sigmoid
sigmoid
HCC1806 BX-912 0 2 72
 8 2.825
0.992
0.159
0.14
0.888
0.141
2.99
0.999
3.32e-09
NA
0.894
0.214
0.854
0.753
0.205
3.07
0.997
2.86e-08
NA
HCC70 MK2206 3 72
sigmoid
sigmoid
HCC70 MK-2206 0 3 72
 8 2.378
1.43
0.423
0.139
0.451
0.39
1.31
0.983
5.28e-06
NA
1.47
0.445
0.859
0.349
0.437
1.44
0.977
1.2e-05
NA
HCC1806 Trametinib 1 72
sigmoid
sigmoid
HCC1806 trametinib 0 1 72
 8 2.751
Inf
0.795
0.139
0.00972
0.802
0.873
0.97
2.67e-05
NA
Inf
0.742
0.822
0.00864
0.752
0.892
0.97
2.67e-05
NA
HCC70 PIK-93 1 72
sigmoid
sigmoid
HCC70 PIK-93 0 1 72
 8 1.442
3.47
0.482
0.137
18.6
-1.0
0.656
0.774
0.0116
NA
10.7
0.649
0.904
10.7
0.0
0.632
0.746
0.0163
NA
HCC1806 Trametinib 2 72
sigmoid
sigmoid
HCC1806 trametinib 0 2 72
 8 2.836
Inf
0.8
0.135
0.00973
0.808
0.873
0.97
2.67e-05
NA
Inf
0.742
0.822
0.00864
0.752
0.892
0.97
2.67e-05
NA
HCC70 BX-912 1 72
sigmoid
sigmoid
HCC70 BX-912 0 1 72
 8 1.436
1.08
-0.227
0.134
1.2
-0.255
3.86
0.99
1.07e-06
NA
1.35
0.256
0.916
1.14
0.242
3.87
0.986
2.78e-06
NA
HCC1806 GDC-0980 3 72
sigmoid
sigmoid
HCC1806 apitolisib 0 3 72
 8 3.149
1.8
0.418
0.132
0.77
0.31
1.14
0.995
1.41e-07
NA
0.947
0.339
0.832
0.475
0.292
1.27
0.993
2.95e-07
NA
HCC38 ZSTK474 1 72
sigmoid
sigmoid
HCC38 ZSTK474 0 1 72
 8 1.742
2.47
0.456
0.132
1.34
0.202
0.843
0.991
7.12e-07
NA
9.02
0.575
0.893
1.0
0.426
0.869
0.99
1.01e-06
NA
BT-549 MK2206 3 72
sigmoid
sigmoid
BT549 MK-2206 0 3 72
 8 1.685
Inf
0.714
0.131
0.123
0.711
3.44
0.953
0.000102
NA
Inf
0.771
0.895
0.123
0.768
3.25
0.949
0.000136
NA
Hs 578T Alpelisib 2
flat
flat
Hs578T alpelisib 2
 8 2.513
Inf
0.668
0.131
0.0
0.668
0.01
0.599
0.0647
0.856
Inf
0.634
0.847
0.0
0.634
0.01
0.541
0.0969
0.833
Hs 578T MK2206 2
sigmoid
sigmoid
Hs578T MK-2206 2
 8 2.530
Inf
0.664
0.131
0.0699
0.752
1.34
0.75
0.0156
NA
Inf
0.628
0.848
0.0616
0.717
1.21
0.767
0.0126
NA
HCC38 Pictilisib 3 72
sigmoid
sigmoid
HCC38 pictilisib 0 3 72
 8 1.420
3.12
0.499
0.129
2.45
0.0818
0.738
0.976
1.33e-05
NA
20.5
0.664
0.911
2.24
0.401
0.731
0.974
1.7e-05
NA
HCC1806 BX-912 3 72
sigmoid
sigmoid
HCC1806 BX-912 0 3 72
 8 3.193
1.09
0.234
0.126
0.897
0.217
2.99
0.999
2.85e-09
NA
0.894
0.214
0.853
0.753
0.205
3.07
0.997
2.86e-08
NA