Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T PIK-93 2
sigmoid
sigmoid
Hs578T PIK-93 2
 8 2.467
2.43
0.415
0.0931
3.62
-0.243
0.991
0.991
8.05e-07
NA
2.34
0.426
0.901
1.93
0.0909
1.04
0.987
2.24e-06
NA
Hs 578T PIK-93 1
sigmoid
sigmoid
Hs578T PIK-93 1
 8 2.033
1.44
0.276
0.175
8.38
-1.0
0.624
0.991
6.57e-07
NA
2.0
0.401
0.84
2.0
0.0
0.672
0.99
9.72e-07
NA
Hs 578T Pictilisib 3
sigmoid
sigmoid
Hs578T pictilisib 3
 8 2.911
2.33
0.471
0.168
0.364
0.403
0.883
0.996
5.24e-08
NA
0.97
0.409
0.794
0.228
0.374
0.952
0.996
5.98e-08
NA
Hs 578T Pictilisib 2
sigmoid
sigmoid
Hs578T pictilisib 2
 8 2.512
1.93
0.45
0.194
0.4
0.333
0.696
0.98
8e-06
NA
1.58
0.446
0.787
0.231
0.381
0.746
0.974
1.74e-05
NA
Hs 578T Pictilisib 1
sigmoid
sigmoid
Hs578T pictilisib 1
 8 2.048
0.482
0.341
0.267
0.162
0.295
0.819
0.998
8.97e-09
NA
0.981
0.441
0.759
0.12
0.416
0.847
0.998
6.97e-09
NA
Hs 578T PI103 3
sigmoid
sigmoid
Hs578T PI-103 3
 8 2.807
0.321
0.175
0.26
0.231
0.163
1.21
0.991
8.05e-07
NA
0.232
0.225
0.729
0.145
0.239
1.39
0.986
2.82e-06
NA
Hs 578T PI103 2
sigmoid
sigmoid
Hs578T PI-103 2
 8 2.503
0.223
-0.0213
0.356
0.303
-0.15
0.858
0.999
7.33e-10
NA
0.206
0.167
0.661
0.152
0.121
0.921
0.999
1.9e-09
NA
Hs 578T PI103 1
sigmoid
sigmoid
Hs578T PI-103 1
 8 2.062
0.131
-0.0743
0.433
0.182
-0.173
0.898
0.996
4.43e-08
NA
0.175
0.204
0.643
0.117
0.152
0.898
0.995
1.02e-07
NA
Hs 578T Omipalisib 3
sigmoid
sigmoid
Hs578T omipalisib 3
 8 2.869
0.0255
-0.107
0.615
0.0533
-0.22
0.494
0.99
8.79e-07
NA
0.0145
0.0989
0.392
0.0102
0.0968
0.62
0.993
3.4e-07
NA
Hs 578T Omipalisib 2
sigmoid
sigmoid
Hs578T omipalisib 2
 8 2.507
0.0155
-0.52
0.766
0.239
-1.0
0.402
0.993
3.45e-07
NA
0.0114
0.028
0.355
0.0114
0.0
0.468
0.981
6.9e-06
NA
Hs 578T Omipalisib 1
sigmoid
sigmoid
Hs578T omipalisib 1
 8 2.079
0.00552
-0.546
0.842
0.17
-1.0
0.321
0.98
8.1e-06
NA
0.0079
0.0459
0.351
0.0079
0.0
0.369
0.984
4.12e-06
NA
Hs 578T MK2206 3
sigmoid
sigmoid
Hs578T MK-2206 3
 8 2.883
Inf
0.737
0.0965
0.144
0.768
1.94
0.962
5.58e-05
NA
Inf
0.666
0.873
0.135
0.7
1.85
0.967
3.69e-05
NA
Hs 578T MK2206 2
sigmoid
sigmoid
Hs578T MK-2206 2
 8 2.530
Inf
0.664
0.131
0.0699
0.752
1.34
0.75
0.0156
NA
Inf
0.628
0.848
0.0616
0.717
1.21
0.767
0.0126
NA
Hs 578T MK2206 1
sigmoid
sigmoid
Hs578T MK-2206 1
 8 2.039
Inf
0.608
0.165
0.087
0.665
2.09
0.9
0.00101
NA
Inf
0.641
0.845
0.0803
0.689
1.9
0.908
0.000775
NA
Hs 578T KIN001-244 3
sigmoid
sigmoid
Hs578T KIN001-244 3
 8 2.888
Inf
0.866
0.00909
5.05
0.617
1.35
0.858
0.00289
NA
50.0
0.818
0.988
5.2
0.474
1.31
0.842
0.00391
NA
Hs 578T KIN001-244 2
sigmoid
sigmoid
Hs578T KIN001-244 2
 8 2.505
Inf
0.819
0.0357
4.8
0.531
1.14
0.891
0.0013
NA
44.3
0.788
0.957
4.79
0.457
1.1
0.878
0.0018
NA
Hs 578T KIN001-244 1
sigmoid
sigmoid
Hs578T KIN001-244 1
 8 2.041
24.7
0.739
0.0391
4.05
0.414
0.972
0.968
3.4e-05
NA
Inf
0.752
0.962
3.15
0.51
0.99
0.964
4.65e-05
NA
Hs 578T CAL-101 3
sigmoid
sigmoid
Hs578T idelalisib 3
 8 2.874
Inf
0.854
0.0202
1.12
0.835
1.91
0.991
6.68e-07
NA
Inf
0.805
0.972
1.07
0.781
1.92
0.99
9.77e-07
NA
Hs 578T CAL-101 2
sigmoid
sigmoid
Hs578T idelalisib 2
 8 2.534
57.5
0.801
0.0636
320.0
-0.507
0.408
0.979
9.58e-06
NA
Inf
0.766
0.923
4.27
0.505
0.495
0.975
1.65e-05
NA
Hs 578T CAL-101 1
sigmoid
sigmoid
Hs578T idelalisib 1
 8 2.050
27.9
0.72
0.0764
4.56
0.356
0.688
0.945
0.000168
NA
18.7
0.734
0.925
18.7
0.0
0.568
0.941
0.000203
NA
Hs 578T Everolimus 3
flat
flat
Hs578T everolimus 3
 8 2.848
Inf
0.664
0.299
0.0
0.664
0.01
0.475
0.144
0.702
Inf
0.592
0.631
0.0
0.592
0.01
0.486
0.136
0.632
Hs 578T Everolimus 2
sigmoid
sigmoid
Hs578T everolimus 2
 8 2.550
3210000000.0
0.626
0.335
0.000205
0.476
0.1
0.791
0.00913
NA
18938.0
0.59
0.627
0.000153
0.422
0.1
0.745
0.0166
NA
Hs 578T Everolimus 1
sigmoid
sigmoid
Hs578T everolimus 1
 8 2.030
1707115.0
0.626
0.318
0.00576
0.429
0.1
0.895
0.00116
NA
2.51e+21
0.657
0.704
0.00121
0.502
0.1
0.893
0.00124
NA
Hs 578T Dactolisib 3
sigmoid
sigmoid
Hs578T dactolisib 3
 8 2.837
0.0118
0.0569
0.624
0.00848
0.115
0.799
0.96
6.53e-05
NA
0.00728
0.164
0.377
0.0043
0.212
1.05
0.968
3.34e-05
NA
Hs 578T Dactolisib 2
sigmoid
sigmoid
Hs578T dactolisib 2
 8 2.509
0.0128
-0.0617
0.655
0.0126
0.00741
0.79
0.974
1.78e-05
NA
0.0105
0.15
0.405
0.00638
0.203
1.04
0.985
3.67e-06
NA