Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC70 KIN001-244 1 72
flat
flat
HCC70 KIN001-244 0 1 72
 8 1.350
Inf
0.889
0.00722
0.0
0.889
0.01
0.616
0.0568
0.988
Inf
0.926
0.995
0.0
0.926
0.01
0.612
0.0584
0.992
HCC70 GDC-0980 1 72
sigmoid
sigmoid
HCC70 apitolisib 0 1 72
 8 1.350
0.211
-0.312
0.362
0.339
-0.362
1.15
0.985
3.24e-06
NA
0.441
0.237
0.779
0.266
0.236
1.26
0.985
3.31e-06
NA
HCC70 Torin1 1 72
sigmoid
sigmoid
HCC70 Torin1 0 1 72
 8 1.345
0.0472
0.15
0.487
0.0311
0.149
0.849
0.973
1.89e-05
NA
0.93
0.475
0.693
0.0276
0.475
0.854
0.973
2.05e-05
NA
HCC38 AS605240 3 72
flat
flat
HCC38 AS-605240 0 3 72
 8 1.343
Inf
0.958
-0.0162
0.0
0.958
0.01
-0.233
1.0
1.01
Inf
0.972
1.01
0.0
0.972
0.01
-0.235
1.0
1.01
HCC70 AZD8055 1 72
sigmoid
sigmoid
HCC70 AZD8055 0 1 72
 8 1.339
0.0485
0.242
0.442
0.0243
0.26
1.06
0.976
1.32e-05
NA
Inf
0.529
0.721
0.0222
0.54
1.08
0.974
1.81e-05
NA
HCC70 ZSTK474 1 72
sigmoid
sigmoid
HCC70 ZSTK474 0 1 72
 8 1.332
0.167
-0.265
0.366
0.201
-0.206
1.85
0.975
1.56e-05
NA
0.289
0.264
0.782
0.182
0.299
1.96
0.971
2.35e-05
NA
HCC70 PI103 1 72
sigmoid
sigmoid
HCC70 PI-103 0 1 72
 8 1.305
1.04
-0.0102
0.104
1.14
-0.107
2.26
0.957
7.9e-05
NA
1.83
0.399
0.938
1.08
0.349
2.28
0.949
0.000133
NA