Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Omipalisib | 1 | sigmoid | sigmoid | Hs578T omipalisib 1 | 8 | 2.079 | 0.00552 | -0.546 | 0.842 | 0.17 | -1.0 | 0.321 | 0.98 | 8.1e-06 | NA | 0.0079 | 0.0459 | 0.351 | 0.0079 | 0.0 | 0.369 | 0.984 | 4.12e-06 | NA | |
| BT-20 | Omipalisib | 1 | 72 | sigmoid | sigmoid | BT20 omipalisib 0 1 72 | 8 | 2.078 | 0.00617 | -0.729 | 0.985 | 0.0283 | -0.739 | 0.596 | 0.97 | 2.83e-05 | NA | 0.00781 | 0.0157 | 0.306 | 0.00685 | 0.0597 | 0.96 | 0.988 | 1.57e-06 | NA |
| Hs 578T | Dactolisib | 3 | sigmoid | sigmoid | Hs578T dactolisib 3 | 8 | 2.837 | 0.0118 | 0.0569 | 0.624 | 0.00848 | 0.115 | 0.799 | 0.96 | 6.53e-05 | NA | 0.00728 | 0.164 | 0.377 | 0.0043 | 0.212 | 1.05 | 0.968 | 3.34e-05 | NA | |
| Hs 578T | Trametinib | 1 | sigmoid | sigmoid | Hs578T trametinib 1 | 8 | 2.044 | 0.00353 | -0.00904 | 0.765 | 0.00516 | -0.0906 | 0.437 | 0.992 | 4.85e-07 | NA | 0.00661 | 0.238 | 0.385 | 0.00213 | 0.201 | 0.456 | 0.993 | 3e-07 | NA | |
| Hs 578T | Trametinib | 2 | sigmoid | sigmoid | Hs578T trametinib 2 | 8 | 2.483 | 0.00633 | 0.074 | 0.701 | 0.00558 | 0.0362 | 0.593 | 0.998 | 1.32e-08 | NA | 0.0058 | 0.214 | 0.361 | 0.00257 | 0.193 | 0.602 | 0.998 | 3.66e-09 | NA | |
| BT-20 | Omipalisib | 3 | 72 | sigmoid | sigmoid | BT20 omipalisib 0 3 72 | 8 | 2.586 | 0.00689 | -0.587 | 0.893 | 0.044 | -0.714 | 0.478 | 0.958 | 7.32e-05 | NA | 0.00572 | 0.017 | 0.281 | 0.00491 | 0.0669 | 0.945 | 0.983 | 4.7e-06 | NA |
| BT-20 | Omipalisib | 2 | 72 | sigmoid | sigmoid | BT20 omipalisib 0 2 72 | 8 | 1.717 | 0.00324 | -0.799 | 1.1 | 0.00361 | -0.354 | 4.99 | 0.808 | 0.00704 | NA | 0.00518 | 0.0194 | 0.291 | 0.00429 | 0.111 | 1.34 | 0.968 | 3.16e-05 | NA |