Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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HCC38 | Buparlisib | 3 | 72 | sigmoid | sigmoid | HCC38 buparlisib 0 3 72 | 8 | 1.431 | 0.674 | -0.377 | 0.272 | 1.67 | -1.0 | 1.21 | 0.991 | 6.94e-07 | NA | 1.11 | 0.188 | 0.824 | 1.11 | 0.0 | 1.32 | 0.987 | 2.46e-06 | NA |
HCC70 | PIK-93 | 1 | 72 | sigmoid | sigmoid | HCC70 PIK-93 0 1 72 | 8 | 1.442 | 3.47 | 0.482 | 0.137 | 18.6 | -1.0 | 0.656 | 0.774 | 0.0116 | NA | 10.7 | 0.649 | 0.904 | 10.7 | 0.0 | 0.632 | 0.746 | 0.0163 | NA |
HCC1806 | Sirolimus | 1 | 72 | sigmoid | sigmoid | HCC1806 rapamycin 0 1 72 | 8 | 2.796 | 1.35 | 0.775 | 0.187 | 0.00019 | 0.706 | 0.1 | 0.661 | 0.039 | NA | 1.05 | 0.717 | 0.76 | 1e-05 | 0.657 | 0.1 | 0.68 | 0.0328 | NA |
HCC1806 | Sirolimus | 3 | 72 | sigmoid | sigmoid | HCC1806 rapamycin 0 3 72 | 8 | 3.249 | 0.223 | 0.805 | 0.162 | 0.000183 | 0.746 | 0.1 | 0.663 | 0.0382 | NA | 1.05 | 0.717 | 0.76 | 1e-05 | 0.657 | 0.1 | 0.68 | 0.0328 | NA |
BT-549 | PIK-93 | 2 | 72 | sigmoid | sigmoid | BT549 PIK-93 0 2 72 | 8 | 1.983 | 7.03 | 0.687 | 0.0641 | 29.9 | -1.0 | 0.759 | 0.956 | 8.81e-05 | NA | 10.4 | 0.713 | 0.939 | 10.4 | 0.0 | 0.788 | 0.949 | 0.000136 | NA |
HCC38 | PI103 | 2 | 72 | sigmoid | sigmoid | HCC38 PI-103 0 2 72 | 8 | 2.094 | 0.856 | 0.226 | 0.167 | 0.672 | 0.135 | 1.3 | 0.986 | 2.7e-06 | NA | 1.04 | 0.359 | 0.851 | 0.488 | 0.33 | 1.43 | 0.981 | 6.52e-06 | NA |
HCC70 | MK2206 | 2 | 72 | sigmoid | sigmoid | HCC70 MK-2206 0 2 72 | 8 | 1.690 | 0.446 | 0.244 | 0.2 | 0.301 | 0.226 | 1.53 | 0.973 | 1.92e-05 | NA | 1.03 | 0.448 | 0.851 | 0.266 | 0.44 | 1.56 | 0.965 | 4.11e-05 | NA |
Hs 578T | BX-912 | 2 | sigmoid | sigmoid | Hs578T BX-912 2 | 8 | 2.540 | 1.07 | -0.019 | 0.174 | 1.79 | -0.489 | 1.33 | 0.998 | 6.37e-09 | NA | 1.01 | 0.164 | 0.828 | 1.01 | 0.0 | 1.4 | 0.996 | 7.64e-08 | NA | |
BT-549 | ZSTK474 | 3 | 72 | sigmoid | sigmoid | BT549 ZSTK474 0 3 72 | 8 | 1.776 | 0.504 | 0.139 | 0.267 | 0.616 | -0.0912 | 0.836 | 0.996 | 7.06e-08 | NA | 0.994 | 0.368 | 0.789 | 0.489 | 0.218 | 0.808 | 0.995 | 9.19e-08 | NA |
HCC70 | Buparlisib | 1 | 72 | sigmoid | sigmoid | HCC70 buparlisib 0 1 72 | 8 | 1.374 | 0.608 | -0.494 | 0.231 | 1.27 | -0.9 | 1.4 | 0.98 | 7.6e-06 | NA | 0.988 | 0.151 | 0.861 | 0.98 | 0.00578 | 1.46 | 0.973 | 1.91e-05 | NA |
Hs 578T | Pictilisib | 1 | sigmoid | sigmoid | Hs578T pictilisib 1 | 8 | 2.048 | 0.482 | 0.341 | 0.267 | 0.162 | 0.295 | 0.819 | 0.998 | 8.97e-09 | NA | 0.981 | 0.441 | 0.759 | 0.12 | 0.416 | 0.847 | 0.998 | 6.97e-09 | NA | |
Hs 578T | Pictilisib | 3 | sigmoid | sigmoid | Hs578T pictilisib 3 | 8 | 2.911 | 2.33 | 0.471 | 0.168 | 0.364 | 0.403 | 0.883 | 0.996 | 5.24e-08 | NA | 0.97 | 0.409 | 0.794 | 0.228 | 0.374 | 0.952 | 0.996 | 5.98e-08 | NA | |
HCC38 | GDC-0980 | 3 | 72 | sigmoid | sigmoid | HCC38 apitolisib 0 3 72 | 8 | 1.437 | 0.371 | -0.0189 | 0.29 | 0.513 | -0.179 | 0.946 | 0.993 | 3.35e-07 | NA | 0.96 | 0.359 | 0.808 | 0.393 | 0.295 | 0.998 | 0.993 | 3.51e-07 | NA |
HCC38 | Buparlisib | 2 | 72 | sigmoid | sigmoid | HCC38 buparlisib 0 2 72 | 8 | 2.142 | 0.876 | -0.185 | 0.172 | 1.24 | -0.413 | 1.74 | 0.996 | 5.03e-08 | NA | 0.959 | 0.146 | 0.861 | 0.893 | 0.0606 | 1.8 | 0.992 | 4.3e-07 | NA |
BT-549 | ZSTK474 | 2 | 72 | sigmoid | sigmoid | BT549 ZSTK474 0 2 72 | 8 | 1.962 | 0.628 | 0.144 | 0.245 | 0.841 | -0.139 | 0.84 | 0.995 | 1.29e-07 | NA | 0.958 | 0.334 | 0.791 | 0.595 | 0.163 | 0.828 | 0.992 | 4.28e-07 | NA |
HCC1806 | GDC-0980 | 1 | 72 | sigmoid | sigmoid | HCC1806 apitolisib 0 1 72 | 8 | 2.696 | 1.24 | 0.339 | 0.152 | 0.739 | 0.223 | 1.15 | 0.995 | 1.52e-07 | NA | 0.947 | 0.339 | 0.832 | 0.475 | 0.292 | 1.27 | 0.993 | 2.95e-07 | NA |
HCC1806 | GDC-0980 | 3 | 72 | sigmoid | sigmoid | HCC1806 apitolisib 0 3 72 | 8 | 3.149 | 1.8 | 0.418 | 0.132 | 0.77 | 0.31 | 1.14 | 0.995 | 1.41e-07 | NA | 0.947 | 0.339 | 0.832 | 0.475 | 0.292 | 1.27 | 0.993 | 2.95e-07 | NA |
HCC1806 | GDC-0980 | 2 | 72 | sigmoid | sigmoid | HCC1806 apitolisib 0 2 72 | 8 | 2.781 | 1.32 | 0.355 | 0.148 | 0.746 | 0.241 | 1.15 | 0.995 | 1.49e-07 | NA | 0.947 | 0.339 | 0.832 | 0.475 | 0.292 | 1.27 | 0.993 | 2.95e-07 | NA |
HCC70 | Buparlisib | 3 | 72 | sigmoid | sigmoid | HCC70 buparlisib 0 3 72 | 8 | 2.439 | 0.968 | -0.156 | 0.167 | 1.7 | -0.624 | 1.43 | 0.995 | 1.16e-07 | NA | 0.944 | 0.122 | 0.852 | 0.944 | 0.0 | 1.57 | 0.988 | 1.57e-06 | NA |
BT-20 | ZSTK474 | 1 | 72 | sigmoid | sigmoid | BT20 ZSTK474 0 1 72 | 8 | 1.940 | 0.788 | 0.0217 | 0.122 | 0.819 | -0.0395 | 1.99 | 0.957 | 7.76e-05 | NA | 0.942 | 0.272 | 0.913 | 0.677 | 0.249 | 2.09 | 0.934 | 0.000293 | NA |
Hs 578T | BX-912 | 3 | sigmoid | sigmoid | Hs578T BX-912 3 | 8 | 2.805 | 1.04 | 0.0121 | 0.125 | 1.09 | -0.0661 | 2.36 | 0.992 | 4.22e-07 | NA | 0.936 | 0.148 | 0.883 | 0.841 | 0.116 | 2.45 | 0.982 | 5.7e-06 | NA | |
HCC70 | Torin1 | 1 | 72 | sigmoid | sigmoid | HCC70 Torin1 0 1 72 | 8 | 1.345 | 0.0472 | 0.15 | 0.487 | 0.0311 | 0.149 | 0.849 | 0.973 | 1.89e-05 | NA | 0.93 | 0.475 | 0.693 | 0.0276 | 0.475 | 0.854 | 0.973 | 2.05e-05 | NA |
BT-549 | Buparlisib | 1 | 72 | sigmoid | sigmoid | BT549 buparlisib 0 1 72 | 8 | 1.837 | 0.729 | -0.325 | 0.253 | 1.83 | -1.0 | 1.19 | 0.994 | 2.4e-07 | NA | 0.926 | 0.136 | 0.807 | 0.926 | 0.0 | 1.37 | 0.987 | 2.46e-06 | NA |
HCC70 | MK2206 | 1 | 72 | sigmoid | sigmoid | HCC70 MK-2206 0 1 72 | 8 | 1.444 | 0.314 | -0.0266 | 0.337 | 0.618 | -0.336 | 0.758 | 0.991 | 6.35e-07 | NA | 0.925 | 0.353 | 0.775 | 0.521 | 0.172 | 0.737 | 0.99 | 1.08e-06 | NA |
Hs 578T | BX-912 | 1 | sigmoid | sigmoid | Hs578T BX-912 1 | 8 | 2.001 | 0.771 | -0.202 | 0.191 | 1.16 | -0.444 | 1.57 | 0.997 | 2.97e-08 | NA | 0.901 | 0.159 | 0.851 | 0.822 | 0.0702 | 1.64 | 0.994 | 1.9e-07 | NA |