Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-549 PIK-93 3 72
sigmoid
sigmoid
BT549 PIK-93 0 3 72
 8 1.807
20.1
0.719
0.0848
231.0
-1.0
0.45
0.716
0.0229
NA
67.9
0.761
0.925
67.9
0.0
0.431
0.686
0.0309
NA
BT-20 Pictilisib 1 72
sigmoid
sigmoid
BT20 pictilisib 0 1 72
 8 2.085
1.25
0.163
0.177
5.0
-1.0
0.791
0.994
1.75e-07
NA
1.52
0.323
0.838
1.52
0.0
0.865
0.989
1.22e-06
NA
BT-20 Pictilisib 2 72
sigmoid
sigmoid
BT20 pictilisib 0 2 72
 8 1.746
0.308
-0.0521
0.379
2.35
-1.0
0.54
0.791
0.00908
NA
0.634
0.272
0.712
0.634
0.0
0.6
0.716
0.0229
NA
BT-20 Torin2 1 72
sigmoid
sigmoid
BT20 Torin2 0 1 72
 8 2.018
0.0185
-0.739
0.803
0.158
-1.0
0.511
0.986
2.9e-06
NA
0.0245
0.0164
0.415
0.0245
0.0
0.616
0.99
1.06e-06
NA
BT-20 Torin2 3 72
sigmoid
sigmoid
BT20 Torin2 0 3 72
 8 2.458
0.019
-0.64
0.751
0.234
-1.0
0.438
0.959
6.92e-05
NA
0.0147
0.0148
0.379
0.0123
0.0598
0.727
0.977
1.28e-05
NA
HCC70 Alpelisib 1 72
sigmoid
sigmoid
HCC70 alpelisib 0 1 72
 8 1.383
4.4
0.574
0.105
20.4
-1.0
0.717
0.78
0.0106
NA
11.9
0.718
0.929
11.9
0.0
0.732
0.768
0.0124
NA
HCC70 PIK-93 1 72
sigmoid
sigmoid
HCC70 PIK-93 0 1 72
 8 1.442
3.47
0.482
0.137
18.6
-1.0
0.656
0.774
0.0116
NA
10.7
0.649
0.904
10.7
0.0
0.632
0.746
0.0163
NA
BT-20 AZD-6482 2 72
sigmoid
sigmoid
BT20 AZD6482 0 2 72
 8 1.645
0.581
0.0253
0.303
3.86
-1.0
0.58
0.904
0.000884
NA
1.34
0.333
0.772
1.34
0.0
0.582
0.864
0.0025
NA
HCC1806 Pictilisib 1 72
sigmoid
sigmoid
HCC1806 pictilisib 0 1 72
 8 2.782
11.7
0.79
0.049
43.7
-1.0
0.831
0.811
0.00677
NA
11.3
0.734
0.935
11.3
0.0
0.849
0.773
0.0116
NA
HCC70 PIK-93 2 72
sigmoid
sigmoid
HCC70 PIK-93 0 2 72
 8 1.705
4.34
0.647
0.0132
9.3
-1.0
1.44
0.888
0.0014
NA
6.01
0.718
0.991
6.01
0.0
1.49
0.872
0.00208
NA
BT-549 Buparlisib 3 72
sigmoid
sigmoid
BT549 buparlisib 0 3 72
 8 1.795
0.602
-0.351
0.295
1.64
-1.0
1.09
0.983
4.52e-06
NA
0.804
0.132
0.777
0.804
0.0
1.26
0.968
3.41e-05
NA
BT-20 Alpelisib 1 72
sigmoid
sigmoid
BT20 alpelisib 0 1 72
 8 2.077
1.14
0.046
0.196
3.52
-1.0
0.977
0.966
4.1e-05
NA
1.32
0.26
0.825
1.32
0.0
1.13
0.942
0.000194
NA
BT-549 PIK-93 2 72
sigmoid
sigmoid
BT549 PIK-93 0 2 72
 8 1.983
7.03
0.687
0.0641
29.9
-1.0
0.759
0.956
8.81e-05
NA
10.4
0.713
0.939
10.4
0.0
0.788
0.949
0.000136
NA
BT-20 Alpelisib 2 72
sigmoid
sigmoid
BT20 alpelisib 0 2 72
 8 1.692
0.253
-0.0994
0.405
2.25
-1.0
0.503
0.835
0.00451
NA
0.612
0.259
0.698
0.612
0.0
0.507
0.764
0.0131
NA
BT-20 MK2206 2 72
sigmoid
sigmoid
BT20 MK-2206 0 2 72
 8 1.739
0.823
0.0896
0.246
4.34
-1.0
0.661
0.965
4.36e-05
NA
1.47
0.348
0.806
1.47
0.0
0.715
0.947
0.000145
NA
BT-20 Alpelisib 3 72
sigmoid
sigmoid
BT20 alpelisib 0 3 72
 8 2.541
1.21
0.199
0.21
5.83
-1.0
0.697
0.881
0.00167
NA
1.12
0.272
0.775
1.12
0.0
0.764
0.791
0.00916
NA
HCC38 Omipalisib 2 72
sigmoid
sigmoid
HCC38 omipalisib 0 2 72
 8 2.124
0.0404
-0.47
0.634
0.45
-1.0
0.456
0.979
9.71e-06
NA
0.0507
0.0595
0.494
0.0507
0.0
0.556
0.96
6.44e-05
NA
HCC70 PIK-93 3 72
sigmoid
sigmoid
HCC70 PIK-93 0 3 72
 8 2.519
21.2
0.756
0.0663
181.0
-1.0
0.513
0.851
0.00333
NA
34.1
0.721
0.92
34.1
0.0
0.473
0.831
0.00487
NA
BT-549 Pictilisib 2 72
sigmoid
sigmoid
BT549 pictilisib 0 2 72
 8 1.960
1.84
0.365
0.166
11.5
-1.0
0.599
0.943
0.000187
NA
2.82
0.473
0.851
2.82
0.0
0.647
0.924
0.000432
NA
HCC70 Torin2 1 72
sigmoid
sigmoid
HCC70 Torin2 0 1 72
 8 1.364
0.0288
-0.732
0.772
0.183
-1.0
0.594
0.991
6.58e-07
NA
0.088
0.0644
0.539
0.088
0.0
0.622
0.988
1.95e-06
NA
BT-20 PIK-93 2 72
sigmoid
sigmoid
BT20 PIK-93 0 2 72
 8 1.798
0.792
0.155
0.286
14.1
-1.0
0.382
0.81
0.00687
NA
2.8
0.373
0.764
2.8
0.0
0.344
0.77
0.0121
NA
BT-549 TGX221 2 72
sigmoid
sigmoid
BT549 TGX-221 0 2 72
 8 1.927
17.5
0.772
0.0551
123.0
-1.0
0.562
0.907
0.000795
NA
32.3
0.792
0.949
32.3
3.45e-05
0.58
0.899
0.00102
NA
HCC1806 Pictilisib 2 72
sigmoid
sigmoid
HCC1806 pictilisib 0 2 72
 8 2.866
12.1
0.796
0.0476
45.4
-1.0
0.831
0.811
0.00671
NA
11.3
0.734
0.935
11.3
0.0
0.849
0.773
0.0116
NA
BT-20 PIK-93 3 72
sigmoid
sigmoid
BT20 PIK-93 0 3 72
 8 2.532
2.65
0.419
0.097
7.54
-1.0
1.05
0.982
5.47e-06
NA
2.5
0.42
0.892
2.5
0.0
1.17
0.971
2.45e-05
NA
BT-549 AZD-6482 2 72
sigmoid
sigmoid
BT549 AZD6482 0 2 72
 8 1.973
9.15
0.635
0.112
120.0
-1.0
0.426
0.951
0.000115
NA
19.4
0.672
0.895
19.4
0.0
0.437
0.946
0.000154
NA