Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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| Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Dactolisib | 2 | sigmoid | sigmoid | Hs578T dactolisib 2 | 8 | 2.509 | 0.0128 | -0.0617 | 0.655 | 0.0126 | 0.00741 | 0.79 | 0.974 | 1.78e-05 | NA | 0.0105 | 0.15 | 0.405 | 0.00638 | 0.203 | 1.04 | 0.985 | 3.67e-06 | NA | |
| HCC70 | BX-912 | 2 | 72 | sigmoid | sigmoid | HCC70 BX-912 0 2 72 | 8 | 1.693 | 1.25 | 0.00257 | 0.0619 | 1.25 | -0.00649 | 5.0 | 0.971 | 2.55e-05 | NA | 1.44 | 0.311 | 0.961 | 1.2 | 0.306 | 5.0 | 0.956 | 8.35e-05 | NA |
| HCC38 | Trametinib | 2 | 72 | sigmoid | sigmoid | HCC38 trametinib 0 2 72 | 8 | 2.133 | 0.219 | 0.267 | 0.389 | 0.222 | -0.00324 | 0.424 | 0.987 | 2.39e-06 | NA | 0.391 | 0.377 | 0.644 | 0.127 | 0.183 | 0.404 | 0.988 | 1.91e-06 | NA |
| BT-549 | ZSTK474 | 1 | 72 | sigmoid | sigmoid | BT549 ZSTK474 0 1 72 | 8 | 1.861 | 0.58 | 0.213 | 0.256 | 0.583 | -0.00205 | 0.771 | 0.992 | 5.43e-07 | NA | 1.12 | 0.394 | 0.788 | 0.428 | 0.261 | 0.767 | 0.989 | 1.49e-06 | NA |
| HCC38 | Dactolisib | 2 | 72 | sigmoid | sigmoid | HCC38 dactolisib 0 2 72 | 8 | 2.120 | 0.0118 | -0.0557 | 0.668 | 0.0118 | -0.00134 | 0.785 | 0.98 | 7.61e-06 | NA | 0.0145 | 0.204 | 0.447 | 0.00701 | 0.245 | 0.927 | 0.988 | 1.88e-06 | NA |
| HCC38 | AZD8055 | 3 | 72 | sigmoid | sigmoid | HCC38 AZD8055 0 3 72 | 8 | 1.417 | 0.0464 | 0.0327 | 0.53 | 0.0463 | 0.000983 | 1.04 | 0.997 | 4.27e-08 | NA | 0.157 | 0.392 | 0.658 | 0.041 | 0.372 | 1.02 | 0.996 | 5.78e-08 | NA |
| BT-549 | Dactolisib | 3 | 72 | sigmoid | sigmoid | BT549 dactolisib 0 3 72 | 8 | 1.801 | 0.0058 | -0.00929 | 0.751 | 0.00579 | 0.000747 | 0.866 | 0.994 | 2.41e-07 | NA | 0.011 | 0.282 | 0.442 | 0.00425 | 0.29 | 0.909 | 0.995 | 1.54e-07 | NA |