Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC38 Everolimus 2 72
sigmoid
flat
HCC38 everolimus 0 2 72
 8 2.170
8323.0
0.58
0.376
0.000127
0.417
0.1
0.688
0.0303
NA
Inf
0.6
0.637
0.0
0.6
0.01
0.509
0.119
0.637
HCC1806 Buparlisib 1 72
sigmoid
sigmoid
HCC1806 buparlisib 0 1 72
 8 2.742
0.748
-0.369
0.226
0.931
-0.415
2.75
1.0
2.95e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
Hs 578T KIN001-244 1
sigmoid
sigmoid
Hs578T KIN001-244 1
 8 2.041
24.7
0.739
0.0391
4.05
0.414
0.972
0.968
3.4e-05
NA
Inf
0.752
0.962
3.15
0.51
0.99
0.964
4.65e-05
NA
HCC38 Buparlisib 2 72
sigmoid
sigmoid
HCC38 buparlisib 0 2 72
 8 2.142
0.876
-0.185
0.172
1.24
-0.413
1.74
0.996
5.03e-08
NA
0.959
0.146
0.861
0.893
0.0606
1.8
0.992
4.3e-07
NA
HCC38 ZSTK474 3 72
sigmoid
sigmoid
HCC38 ZSTK474 0 3 72
 8 1.458
2.06
0.398
0.146
5.06
-0.41
0.665
0.989
1.23e-06
NA
6.44
0.593
0.898
3.35
0.179
0.678
0.988
1.64e-06
NA
Hs 578T Pictilisib 3
sigmoid
sigmoid
Hs578T pictilisib 3
 8 2.911
2.33
0.471
0.168
0.364
0.403
0.883
0.996
5.24e-08
NA
0.97
0.409
0.794
0.228
0.374
0.952
0.996
5.98e-08
NA
HCC1806 Dactolisib 2 72
sigmoid
sigmoid
HCC1806 dactolisib 0 2 72
 8 2.828
0.145
-0.0528
0.433
0.401
-0.401
0.578
0.986
2.83e-06
NA
0.0977
0.121
0.559
0.0929
0.0151
0.619
0.986
2.47e-06
NA
BT-549 Everolimus 3 72
sigmoid
flat
BT549 everolimus 0 3 72
 8 1.587
59.5
0.533
0.425
1e-05
0.395
0.1
0.702
0.0264
NA
Inf
0.656
0.685
0.0
0.656
0.01
0.48
0.141
0.685
HCC1806 Buparlisib 2 72
sigmoid
sigmoid
HCC1806 buparlisib 0 2 72
 8 2.827
0.759
-0.346
0.221
0.937
-0.392
2.75
1.0
2.72e-11
NA
0.69
0.0423
0.803
0.674
0.033
2.99
0.999
1.17e-09
NA
HCC70 MK2206 3 72
sigmoid
sigmoid
HCC70 MK-2206 0 3 72
 8 2.378
1.43
0.423
0.139
0.451
0.39
1.31
0.983
5.28e-06
NA
1.47
0.445
0.859
0.349
0.437
1.44
0.977
1.2e-05
NA
HCC70 AZD8055 2 72
sigmoid
sigmoid
HCC70 AZD8055 0 2 72
 8 1.724
0.17
0.404
0.346
0.0331
0.385
0.897
0.996
7.36e-08
NA
Inf
0.543
0.728
0.0284
0.531
0.905
0.996
6.22e-08
NA
HCC70 Omipalisib 3 72
sigmoid
sigmoid
HCC70 omipalisib 0 3 72
 8 2.458
0.0158
-0.404
0.771
0.0319
-0.379
0.8
0.99
8.95e-07
NA
0.0148
0.051
0.376
0.0127
0.0733
1.02
0.996
4.59e-08
NA
HCC38 Pictilisib 1 72
sigmoid
sigmoid
HCC38 pictilisib 0 1 72
 8 1.759
7.16
0.562
0.125
1.04
0.377
0.725
0.992
5.12e-07
NA
Inf
0.647
0.896
0.797
0.529
0.742
0.992
5.77e-07
NA
HCC38 Torin2 1 72
sigmoid
sigmoid
HCC38 Torin2 0 1 72
 8 1.778
0.0133
-0.318
0.753
0.0337
-0.369
0.594
0.994
1.98e-07
NA
0.0264
0.148
0.459
0.0158
0.145
0.664
0.994
1.7e-07
NA
BT-549 Everolimus 1 72
sigmoid
sigmoid
BT549 everolimus 0 1 72
 8 1.772
5.64
0.503
0.444
1e-05
0.367
0.1
0.911
0.000706
NA
437200.0
0.603
0.641
0.000146
0.444
0.1
0.858
0.00286
NA
HCC70 GDC-0980 1 72
sigmoid
sigmoid
HCC70 apitolisib 0 1 72
 8 1.350
0.211
-0.312
0.362
0.339
-0.362
1.15
0.985
3.24e-06
NA
0.441
0.237
0.779
0.266
0.236
1.26
0.985
3.31e-06
NA
HCC38 Sirolimus 3 72
sigmoid
sigmoid
HCC38 rapamycin 0 3 72
 8 1.420
86.3
0.535
0.403
0.000236
0.361
0.1
0.901
0.000982
NA
75575.0
0.687
0.727
0.000198
0.569
0.1
0.889
0.00136
NA
HCC38 PIK-93 3 72
sigmoid
sigmoid
HCC38 PIK-93 0 3 72
 8 1.382
5.05
0.598
0.061
2.34
0.358
1.63
0.919
0.000533
NA
Inf
0.734
0.959
2.23
0.586
1.64
0.914
0.000645
NA
Hs 578T CAL-101 1
sigmoid
sigmoid
Hs578T idelalisib 1
 8 2.050
27.9
0.72
0.0764
4.56
0.356
0.688
0.945
0.000168
NA
18.7
0.734
0.925
18.7
0.0
0.568
0.941
0.000203
NA
BT-549 TGX221 3 72
sigmoid
sigmoid
BT549 TGX-221 0 3 72
 8 1.768
93790.0
0.805
0.0889
320.0
0.356
0.22
0.707
0.0251
NA
49050766.0
0.834
0.923
320.0
0.461
0.214
0.703
0.0263
NA
BT-20 Omipalisib 2 72
sigmoid
sigmoid
BT20 omipalisib 0 2 72
 8 1.717
0.00324
-0.799
1.1
0.00361
-0.354
4.99
0.808
0.00704
NA
0.00518
0.0194
0.291
0.00429
0.111
1.34
0.968
3.16e-05
NA
HCC70 WYE-125132 1 72
sigmoid
sigmoid
HCC70 WYE-132 0 1 72
 8 1.382
0.0518
0.346
0.418
0.0175
0.348
1.1
0.985
3.58e-06
NA
Inf
0.579
0.727
0.0165
0.579
1.09
0.983
4.63e-06
NA
HCC38 Everolimus 1 72
sigmoid
flat
HCC38 everolimus 0 1 72
 8 1.703
11.8
0.54
0.428
0.000126
0.341
0.1
0.688
0.0303
NA
Inf
0.641
0.664
0.0
0.641
0.01
0.571
0.0788
0.665
HCC70 Trametinib 1 72
sigmoid
sigmoid
HCC70 trametinib 0 1 72
 8 1.421
0.015
0.339
0.521
0.00411
0.34
0.879
0.966
4.1e-05
NA
Inf
0.566
0.653
0.00373
0.566
0.875
0.968
3.23e-05
NA
HCC70 AS605240 2 72
sigmoid
sigmoid
HCC70 AS-605240 0 2 72
 8 1.771
6.13
0.558
0.126
1.21
0.339
0.698
0.981
7.24e-06
NA
785.0
0.643
0.894
0.946
0.496
0.708
0.978
1.04e-05
NA