Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
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HCC1806 | WYE-125132 | 2 | 72 | sigmoid | sigmoid | HCC1806 WYE-132 0 2 72 | 8 | 2.874 | 0.872 | 0.479 | 0.284 | 0.045 | 0.464 | 0.883 | 0.997 | 3.66e-08 | NA | 0.226 | 0.42 | 0.663 | 0.0335 | 0.402 | 0.855 | 0.996 | 8.79e-08 | NA |
HCC70 | Buparlisib | 2 | 72 | sigmoid | sigmoid | HCC70 buparlisib 0 2 72 | 8 | 1.724 | 0.861 | -0.272 | 0.162 | 1.33 | -0.556 | 1.71 | 0.989 | 1.21e-06 | NA | 1.12 | 0.175 | 0.888 | 1.03 | 0.0639 | 1.76 | 0.982 | 5.47e-06 | NA |
HCC38 | PI103 | 2 | 72 | sigmoid | sigmoid | HCC38 PI-103 0 2 72 | 8 | 2.094 | 0.856 | 0.226 | 0.167 | 0.672 | 0.135 | 1.3 | 0.986 | 2.7e-06 | NA | 1.04 | 0.359 | 0.851 | 0.488 | 0.33 | 1.43 | 0.981 | 6.52e-06 | NA |
BT-20 | Pictilisib | 3 | 72 | sigmoid | sigmoid | BT20 pictilisib 0 3 72 | 8 | 2.566 | 0.839 | 0.172 | 0.22 | 0.914 | -0.0483 | 1.09 | 0.954 | 9.59e-05 | NA | 0.843 | 0.254 | 0.768 | 0.809 | 0.0179 | 0.898 | 0.918 | 0.000551 | NA |
BT-20 | MK2206 | 2 | 72 | sigmoid | sigmoid | BT20 MK-2206 0 2 72 | 8 | 1.739 | 0.823 | 0.0896 | 0.246 | 4.34 | -1.0 | 0.661 | 0.965 | 4.36e-05 | NA | 1.47 | 0.348 | 0.806 | 1.47 | 0.0 | 0.715 | 0.947 | 0.000145 | NA |
HCC70 | Pictilisib | 2 | 72 | sigmoid | sigmoid | HCC70 pictilisib 0 2 72 | 8 | 1.783 | 0.811 | 0.124 | 0.189 | 0.858 | -0.0372 | 1.27 | 0.973 | 2.08e-05 | NA | 1.25 | 0.358 | 0.852 | 0.678 | 0.278 | 1.32 | 0.963 | 5.09e-05 | NA |
HCC1806 | Buparlisib | 3 | 72 | sigmoid | sigmoid | HCC1806 buparlisib 0 3 72 | 8 | 3.195 | 0.808 | -0.257 | 0.203 | 0.96 | -0.303 | 2.74 | 1.0 | 2.03e-11 | NA | 0.69 | 0.0423 | 0.803 | 0.674 | 0.033 | 2.99 | 0.999 | 1.17e-09 | NA |
BT-20 | PIK-93 | 2 | 72 | sigmoid | sigmoid | BT20 PIK-93 0 2 72 | 8 | 1.798 | 0.792 | 0.155 | 0.286 | 14.1 | -1.0 | 0.382 | 0.81 | 0.00687 | NA | 2.8 | 0.373 | 0.764 | 2.8 | 0.0 | 0.344 | 0.77 | 0.0121 | NA |
BT-20 | ZSTK474 | 1 | 72 | sigmoid | sigmoid | BT20 ZSTK474 0 1 72 | 8 | 1.940 | 0.788 | 0.0217 | 0.122 | 0.819 | -0.0395 | 1.99 | 0.957 | 7.76e-05 | NA | 0.942 | 0.272 | 0.913 | 0.677 | 0.249 | 2.09 | 0.934 | 0.000293 | NA |
Hs 578T | Buparlisib | 3 | sigmoid | sigmoid | Hs578T buparlisib 3 | 8 | 2.890 | 0.778 | -0.425 | 0.233 | 1.71 | -1.0 | 1.4 | 0.998 | 1.34e-08 | NA | 0.622 | 0.0272 | 0.779 | 0.622 | 0.0 | 1.57 | 0.991 | 8.01e-07 | NA | |
Hs 578T | BX-912 | 1 | sigmoid | sigmoid | Hs578T BX-912 1 | 8 | 2.001 | 0.771 | -0.202 | 0.191 | 1.16 | -0.444 | 1.57 | 0.997 | 2.97e-08 | NA | 0.901 | 0.159 | 0.851 | 0.822 | 0.0702 | 1.64 | 0.994 | 1.9e-07 | NA | |
BT-20 | Trametinib | 2 | 72 | sigmoid | sigmoid | BT20 trametinib 0 2 72 | 8 | 1.723 | 0.761 | 0.303 | 0.289 | 11.1 | -0.768 | 0.347 | 0.965 | 4.13e-05 | NA | 2.56 | 0.478 | 0.77 | 2.56 | 0.0 | 0.362 | 0.957 | 8.16e-05 | NA |
HCC1806 | Buparlisib | 2 | 72 | sigmoid | sigmoid | HCC1806 buparlisib 0 2 72 | 8 | 2.827 | 0.759 | -0.346 | 0.221 | 0.937 | -0.392 | 2.75 | 1.0 | 2.72e-11 | NA | 0.69 | 0.0423 | 0.803 | 0.674 | 0.033 | 2.99 | 0.999 | 1.17e-09 | NA |
Hs 578T | AS605240 | 1 | sigmoid | sigmoid | Hs578T AS-605240 1 | 8 | 2.015 | 0.758 | 0.341 | 0.212 | 0.333 | 0.265 | 0.921 | 0.991 | 7.83e-07 | NA | 1.42 | 0.447 | 0.811 | 0.246 | 0.408 | 0.964 | 0.989 | 1.51e-06 | NA | |
HCC38 | PI103 | 1 | 72 | sigmoid | sigmoid | HCC38 PI-103 0 1 72 | 8 | 1.782 | 0.755 | 0.222 | 0.201 | 0.601 | 0.12 | 1.2 | 0.996 | 4.45e-08 | NA | 1.39 | 0.416 | 0.839 | 0.494 | 0.359 | 1.23 | 0.995 | 1.01e-07 | NA |
HCC1806 | Buparlisib | 1 | 72 | sigmoid | sigmoid | HCC1806 buparlisib 0 1 72 | 8 | 2.742 | 0.748 | -0.369 | 0.226 | 0.931 | -0.415 | 2.75 | 1.0 | 2.95e-11 | NA | 0.69 | 0.0423 | 0.803 | 0.674 | 0.033 | 2.99 | 0.999 | 1.17e-09 | NA |
HCC70 | Dactolisib | 3 | 72 | sigmoid | sigmoid | HCC70 dactolisib 0 3 72 | 8 | 2.430 | 0.738 | 0.321 | 0.312 | 18.6 | -0.818 | 0.3 | 0.975 | 1.64e-05 | NA | 0.688 | 0.365 | 0.675 | 0.635 | 0.0134 | 0.338 | 0.97 | 2.7e-05 | NA |
BT-549 | Buparlisib | 1 | 72 | sigmoid | sigmoid | BT549 buparlisib 0 1 72 | 8 | 1.837 | 0.729 | -0.325 | 0.253 | 1.83 | -1.0 | 1.19 | 0.994 | 2.4e-07 | NA | 0.926 | 0.136 | 0.807 | 0.926 | 0.0 | 1.37 | 0.987 | 2.46e-06 | NA |
Hs 578T | ZSTK474 | 2 | sigmoid | sigmoid | Hs578T ZSTK474 2 | 8 | 2.554 | 0.715 | 0.187 | 0.263 | 5.92 | -0.896 | 0.485 | 0.995 | 1.27e-07 | NA | 0.583 | 0.264 | 0.722 | 0.583 | 0.0 | 0.56 | 0.993 | 3.28e-07 | NA | |
BT-549 | Buparlisib | 2 | 72 | sigmoid | sigmoid | BT549 buparlisib 0 2 72 | 8 | 1.913 | 0.681 | -0.306 | 0.217 | 1.08 | -0.538 | 1.59 | 0.998 | 1.31e-08 | NA | 0.821 | 0.132 | 0.838 | 0.769 | 0.0514 | 1.66 | 0.996 | 8.95e-08 | NA |
HCC38 | Buparlisib | 3 | 72 | sigmoid | sigmoid | HCC38 buparlisib 0 3 72 | 8 | 1.431 | 0.674 | -0.377 | 0.272 | 1.67 | -1.0 | 1.21 | 0.991 | 6.94e-07 | NA | 1.11 | 0.188 | 0.824 | 1.11 | 0.0 | 1.32 | 0.987 | 2.46e-06 | NA |
Hs 578T | Buparlisib | 2 | sigmoid | sigmoid | Hs578T buparlisib 2 | 8 | 2.513 | 0.665 | -0.42 | 0.251 | 1.61 | -1.0 | 1.24 | 0.998 | 1.14e-08 | NA | 0.595 | 0.0445 | 0.779 | 0.595 | 0.0 | 1.36 | 0.994 | 2.48e-07 | NA | |
BT-20 | PI103 | 1 | 72 | sigmoid | sigmoid | BT20 PI-103 0 1 72 | 8 | 1.924 | 0.646 | -0.0114 | 0.16 | 0.659 | -0.0268 | 2.6 | 0.978 | 1.1e-05 | NA | 0.753 | 0.258 | 0.883 | 0.579 | 0.252 | 2.68 | 0.964 | 4.79e-05 | NA |
BT-20 | Buparlisib | 3 | 72 | sigmoid | sigmoid | BT20 buparlisib 0 3 72 | 8 | 2.529 | 0.629 | -0.303 | 0.26 | 1.06 | -0.565 | 1.46 | 0.994 | 2.13e-07 | NA | 0.603 | 0.0696 | 0.764 | 0.603 | 0.0 | 1.52 | 0.984 | 4.36e-06 | NA |
BT-549 | ZSTK474 | 2 | 72 | sigmoid | sigmoid | BT549 ZSTK474 0 2 72 | 8 | 1.962 | 0.628 | 0.144 | 0.245 | 0.841 | -0.139 | 0.84 | 0.995 | 1.29e-07 | NA | 0.958 | 0.334 | 0.791 | 0.595 | 0.163 | 0.828 | 0.992 | 4.28e-07 | NA |