Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
Hs 578T TGX221 3
sigmoid
sigmoid
Hs578T TGX-221 3
 8 2.818
24.2
0.885
0.0148
88.9
-1.0
0.843
0.958
7.66e-05
NA
23.4
0.846
0.98
23.4
0.0
0.862
0.953
0.000103
NA
BT-549 Pictilisib 2 72
sigmoid
sigmoid
BT549 pictilisib 0 2 72
 8 1.960
1.84
0.365
0.166
11.5
-1.0
0.599
0.943
0.000187
NA
2.82
0.473
0.851
2.82
0.0
0.647
0.924
0.000432
NA
BT-549 Pictilisib 3 72
sigmoid
sigmoid
BT549 pictilisib 0 3 72
 8 1.767
1.42
0.276
0.169
4.62
-0.67
0.722
0.998
9.61e-09
NA
2.47
0.452
0.863
2.47
0.0
0.742
0.997
2.13e-08
NA
BT-20 AZD-6482 1 72
sigmoid
sigmoid
BT20 AZD6482 0 1 72
 8 2.043
1.34
0.182
0.173
3.83
-0.782
0.893
0.982
5.6e-06
NA
1.65
0.342
0.845
1.65
0.0
0.977
0.972
2.09e-05
NA
BT-549 PIK-93 3 72
sigmoid
sigmoid
BT549 PIK-93 0 3 72
 8 1.807
20.1
0.719
0.0848
231.0
-1.0
0.45
0.716
0.0229
NA
67.9
0.761
0.925
67.9
0.0
0.431
0.686
0.0309
NA
Hs 578T ZSTK474 2
sigmoid
sigmoid
Hs578T ZSTK474 2
 8 2.554
0.715
0.187
0.263
5.92
-0.896
0.485
0.995
1.27e-07
NA
0.583
0.264
0.722
0.583
0.0
0.56
0.993
3.28e-07
NA
BT-20 PIK-93 1 72
sigmoid
sigmoid
BT20 PIK-93 0 1 72
 8 2.025
2.65
0.406
0.0864
6.54
-1.0
1.22
0.993
3.89e-07
NA
3.15
0.49
0.92
3.15
0.0
1.31
0.989
1.33e-06
NA