Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

 Full screen view
Filter results: >>>>
Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC70 Pictilisib 2 72
sigmoid
sigmoid
HCC70 pictilisib 0 2 72
 8 1.783
0.811
0.124
0.189
0.858
-0.0372
1.27
0.973
2.08e-05
NA
1.25
0.358
0.852
0.678
0.278
1.32
0.963
5.09e-05
NA
HCC38 Dactolisib 3 72
sigmoid
sigmoid
HCC38 dactolisib 0 3 72
 8 1.468
0.0082
-0.197
0.778
0.0127
-0.181
0.711
0.993
3.98e-07
NA
0.0268
0.262
0.497
0.00923
0.277
0.757
0.994
2.62e-07
NA
Hs 578T WYE-125132 1
sigmoid
sigmoid
Hs578T WYE-132 1
 8 2.015
0.0322
0.0601
0.551
0.0286
0.0544
0.962
0.998
4.17e-09
NA
0.0469
0.278
0.55
0.0207
0.275
0.978
0.999
2.33e-09
NA
HCC70 ZSTK474 3 72
sigmoid
sigmoid
HCC70 ZSTK474 0 3 72
 8 2.502
0.455
0.176
0.223
0.345
0.155
1.35
0.991
8.07e-07
NA
0.401
0.265
0.782
0.24
0.274
1.55
0.987
1.99e-06
NA
Hs 578T AZD8055 1
sigmoid
sigmoid
Hs578T AZD8055 1
 8 2.009
0.0391
0.073
0.531
0.0347
0.0546
0.975
0.995
1.39e-07
NA
0.0591
0.286
0.565
0.0259
0.27
0.941
0.994
1.73e-07
NA
HCC38 Torin1 2 72
sigmoid
sigmoid
HCC38 Torin1 0 2 72
 8 2.136
0.0241
0.0393
0.573
0.0203
0.0651
0.82
0.995
1.24e-07
NA
0.0309
0.247
0.512
0.013
0.267
0.88
0.996
4.87e-08
NA
HCC70 GDC-0980 3 72
sigmoid
sigmoid
HCC70 apitolisib 0 3 72
 8 2.423
0.623
0.206
0.211
0.509
0.0878
0.959
0.986
2.55e-06
NA
0.568
0.293
0.792
0.283
0.266
1.09
0.981
6.41e-06
NA
HCC70 BX-912 3 72
sigmoid
sigmoid
HCC70 BX-912 0 3 72
 8 2.465
1.26
0.174
0.0739
1.16
0.168
5.0
0.988
1.75e-06
NA
1.26
0.269
0.935
1.08
0.265
5.0
0.977
1.15e-05
NA
HCC70 Pictilisib 1 72
sigmoid
sigmoid
HCC70 pictilisib 0 1 72
 8 1.409
0.408
-0.099
0.284
0.578
-0.245
1.14
0.996
7.62e-08
NA
0.888
0.325
0.816
0.477
0.261
1.19
0.995
1.2e-07
NA
BT-549 PI103 2 72
sigmoid
sigmoid
BT549 PI-103 0 2 72
 8 1.893
0.218
0.0201
0.344
0.229
-0.0262
1.08
0.997
2.55e-08
NA
0.326
0.28
0.725
0.169
0.261
1.13
0.996
6.2e-08
NA
BT-549 ZSTK474 1 72
sigmoid
sigmoid
BT549 ZSTK474 0 1 72
 8 1.861
0.58
0.213
0.256
0.583
-0.00205
0.771
0.992
5.43e-07
NA
1.12
0.394
0.788
0.428
0.261
0.767
0.989
1.49e-06
NA
HCC1806 Torin1 1 72
sigmoid
sigmoid
HCC1806 Torin1 0 1 72
 8 2.755
0.303
0.246
0.317
0.152
0.185
0.669
0.988
1.74e-06
NA
0.186
0.272
0.651
0.0697
0.26
0.75
0.992
4.55e-07
NA
HCC1806 Torin1 2 72
sigmoid
sigmoid
HCC1806 Torin1 0 2 72
 8 2.840
0.336
0.264
0.309
0.154
0.203
0.668
0.988
1.77e-06
NA
0.186
0.272
0.651
0.0697
0.26
0.75
0.992
4.55e-07
NA
HCC1806 Torin1 3 72
sigmoid
sigmoid
HCC1806 Torin1 0 3 72
 8 3.208
0.537
0.332
0.278
0.165
0.271
0.662
0.988
1.91e-06
NA
0.186
0.272
0.651
0.0697
0.26
0.75
0.992
4.55e-07
NA
Hs 578T Dactolisib 1
sigmoid
sigmoid
Hs578T dactolisib 1
 8 2.047
0.00952
-0.0606
0.691
0.00928
0.0117
0.91
0.977
1.27e-05
NA
0.0124
0.213
0.443
0.00621
0.259
1.06
0.985
3.61e-06
NA
BT-549 GDC-0980 2 72
sigmoid
sigmoid
BT549 apitolisib 0 2 72
 8 1.939
0.189
0.0264
0.357
0.193
-0.011
1.04
0.997
2.98e-08
NA
0.278
0.274
0.71
0.142
0.257
1.07
0.997
3.64e-08
NA
BT-20 WYE-125132 2 72
sigmoid
sigmoid
BT20 WYE-132 0 2 72
 8 2.053
0.012
0.142
0.633
0.00936
0.072
0.621
0.909
0.000752
NA
0.0232
0.316
0.475
0.00613
0.255
0.536
0.894
0.00119
NA
BT-549 Trametinib 1 72
sigmoid
sigmoid
BT549 trametinib 0 1 72
 8 1.812
Inf
0.596
0.202
0.131
0.523
0.61
0.959
6.65e-05
NA
28.3
0.664
0.828
3.47
0.254
0.337
0.933
0.000305
NA
HCC70 GDC-0980 2 72
sigmoid
sigmoid
HCC70 apitolisib 0 2 72
 8 1.676
0.318
-0.0849
0.284
0.451
-0.205
0.983
0.976
1.34e-05
NA
0.536
0.27
0.795
0.285
0.252
1.11
0.972
2.28e-05
NA
BT-20 PI103 1 72
sigmoid
sigmoid
BT20 PI-103 0 1 72
 8 1.924
0.646
-0.0114
0.16
0.659
-0.0268
2.6
0.978
1.1e-05
NA
0.753
0.258
0.883
0.579
0.252
2.68
0.964
4.79e-05
NA
BT-20 ZSTK474 1 72
sigmoid
sigmoid
BT20 ZSTK474 0 1 72
 8 1.940
0.788
0.0217
0.122
0.819
-0.0395
1.99
0.957
7.76e-05
NA
0.942
0.272
0.913
0.677
0.249
2.09
0.934
0.000293
NA
Hs 578T AZD8055 2
sigmoid
sigmoid
Hs578T AZD8055 2
 8 2.480
0.0521
0.149
0.469
0.0387
0.142
1.13
0.999
3.49e-10
NA
0.0495
0.253
0.557
0.0273
0.249
1.16
0.999
4.45e-10
NA
BT-20 WYE-125132 3 72
sigmoid
sigmoid
BT20 WYE-132 0 3 72
 8 2.654
0.0504
0.282
0.465
0.0254
0.236
0.929
0.922
0.000468
NA
0.048
0.307
0.526
0.0182
0.246
0.698
0.918
0.000553
NA
HCC38 Dactolisib 2 72
sigmoid
sigmoid
HCC38 dactolisib 0 2 72
 8 2.120
0.0118
-0.0557
0.668
0.0118
-0.00134
0.785
0.98
7.61e-06
NA
0.0145
0.204
0.447
0.00701
0.245
0.927
0.988
1.88e-06
NA
HCC38 Torin1 3 72
sigmoid
sigmoid
HCC38 Torin1 0 3 72
 8 1.441
0.0231
-0.202
0.666
0.0412
-0.248
0.698
0.999
5.79e-10
NA
0.0787
0.266
0.572
0.0306
0.245
0.714
0.999
5.55e-10
NA