Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
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| Cell line | Drug name | Experimental replicate | Timepoint | Curve type (GR values) | Curve type (relative cell counts) | Experiment name | Number of concentrations | Cell doublings (DMSO control) | GR50 | GRmax | GR_AOC | GEC50 | GRinf | Hill slope (GR values) | R-squared sigmoid fit (GR values) | P-value sigmoid fit (GR values) | R-squared flat fit (GR values) | IC50 | Emax | AUC | EC50 | Einf | Hill slope (relative cell counts) | R-squared sigmoid fit (relative cell counts) | P-value sigmoid fit (relative cell counts) | R-squared flat fit (relative cell counts) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Torin2 | 2 | sigmoid | sigmoid | Hs578T Torin2 2 | 8 | 2.528 | 0.0153 | -0.467 | 0.778 | 0.112 | -0.771 | 0.47 | 0.986 | 2.55e-06 | NA | 0.0122 | 0.0353 | 0.352 | 0.0109 | 0.036 | 0.668 | 0.984 | 4.09e-06 | NA | |
| Hs 578T | Omipalisib | 1 | sigmoid | sigmoid | Hs578T omipalisib 1 | 8 | 2.079 | 0.00552 | -0.546 | 0.842 | 0.17 | -1.0 | 0.321 | 0.98 | 8.1e-06 | NA | 0.0079 | 0.0459 | 0.351 | 0.0079 | 0.0 | 0.369 | 0.984 | 4.12e-06 | NA | |
| HCC70 | Omipalisib | 1 | 72 | sigmoid | sigmoid | HCC70 omipalisib 0 1 72 | 8 | 1.358 | 0.00496 | -0.785 | 1.14 | 0.0157 | -0.775 | 0.812 | 0.989 | 1.34e-06 | NA | 0.0123 | 0.0486 | 0.349 | 0.011 | 0.0462 | 0.833 | 0.984 | 3.73e-06 | NA |
| BT-20 | Torin2 | 2 | 72 | sigmoid | sigmoid | BT20 Torin2 0 2 72 | 8 | 1.733 | 0.00315 | -0.761 | 0.992 | 0.0484 | -0.95 | 0.389 | 0.949 | 0.000131 | NA | 0.00804 | 0.0252 | 0.336 | 0.00642 | 0.0613 | 0.583 | 0.974 | 1.77e-05 | NA |
| BT-20 | Omipalisib | 1 | 72 | sigmoid | sigmoid | BT20 omipalisib 0 1 72 | 8 | 2.078 | 0.00617 | -0.729 | 0.985 | 0.0283 | -0.739 | 0.596 | 0.97 | 2.83e-05 | NA | 0.00781 | 0.0157 | 0.306 | 0.00685 | 0.0597 | 0.96 | 0.988 | 1.57e-06 | NA |
| BT-20 | Omipalisib | 2 | 72 | sigmoid | sigmoid | BT20 omipalisib 0 2 72 | 8 | 1.717 | 0.00324 | -0.799 | 1.1 | 0.00361 | -0.354 | 4.99 | 0.808 | 0.00704 | NA | 0.00518 | 0.0194 | 0.291 | 0.00429 | 0.111 | 1.34 | 0.968 | 3.16e-05 | NA |
| BT-20 | Omipalisib | 3 | 72 | sigmoid | sigmoid | BT20 omipalisib 0 3 72 | 8 | 2.586 | 0.00689 | -0.587 | 0.893 | 0.044 | -0.714 | 0.478 | 0.958 | 7.32e-05 | NA | 0.00572 | 0.017 | 0.281 | 0.00491 | 0.0669 | 0.945 | 0.983 | 4.7e-06 | NA |