Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC1806 Everolimus 3 72
sigmoid
sigmoid
HCC1806 everolimus 0 3 72
 8 3.239
Inf
0.813
0.159
0.000271
0.812
0.356
0.879
0.00175
NA
Inf
0.727
0.765
0.00022
0.729
0.377
0.879
0.00177
NA
HCC1806 Everolimus 2 72
sigmoid
sigmoid
HCC1806 everolimus 0 2 72
 8 2.871
Inf
0.79
0.178
0.000277
0.79
0.365
0.879
0.00176
NA
Inf
0.727
0.765
0.000222
0.728
0.374
0.879
0.00178
NA
BT-20 PIK-93 2 72
sigmoid
sigmoid
BT20 PIK-93 0 2 72
 8 1.798
0.792
0.155
0.286
14.1
-1.0
0.382
0.81
0.00687
NA
2.8
0.373
0.764
2.8
0.0
0.344
0.77
0.0121
NA
Hs 578T ZSTK474 1
sigmoid
sigmoid
Hs578T ZSTK474 1
 8 1.968
0.325
0.137
0.279
0.265
0.0807
0.854
0.973
1.94e-05
NA
0.471
0.329
0.764
0.149
0.343
1.01
0.972
2.27e-05
NA
BT-20 Buparlisib 3 72
sigmoid
sigmoid
BT20 buparlisib 0 3 72
 8 2.529
0.629
-0.303
0.26
1.06
-0.565
1.46
0.994
2.13e-07
NA
0.603
0.0696
0.764
0.603
0.0
1.52
0.984
4.36e-06
NA
BT-20 Trametinib 3 72
sigmoid
sigmoid
BT20 trametinib 0 3 72
 8 2.539
Inf
0.64
0.208
0.104
0.541
0.392
0.967
3.69e-05
NA
Inf
0.604
0.761
0.0656
0.513
0.391
0.964
4.56e-05
NA
HCC38 GDC-0980 1 72
sigmoid
sigmoid
HCC38 apitolisib 0 1 72
 8 1.777
0.317
0.114
0.305
0.295
0.0315
0.91
0.99
9.47e-07
NA
0.623
0.354
0.761
0.219
0.315
0.951
0.989
1.26e-06
NA
HCC70 ZSTK474 2 72
sigmoid
sigmoid
HCC70 ZSTK474 0 2 72
 8 1.737
0.248
-0.0397
0.324
0.27
-0.0591
1.33
0.992
5.33e-07
NA
0.379
0.28
0.76
0.214
0.28
1.43
0.989
1.22e-06
NA
HCC1806 Sirolimus 2 72
sigmoid
sigmoid
HCC1806 rapamycin 0 2 72
 8 2.881
0.901
0.782
0.182
0.000189
0.714
0.1
0.661
0.0388
NA
149.0
0.717
0.76
0.000153
0.626
0.1
0.634
0.0489
NA
HCC1806 Sirolimus 1 72
sigmoid
sigmoid
HCC1806 rapamycin 0 1 72
 8 2.796
1.35
0.775
0.187
0.00019
0.706
0.1
0.661
0.039
NA
1.05
0.717
0.76
1e-05
0.657
0.1
0.68
0.0328
NA
HCC1806 Sirolimus 3 72
sigmoid
sigmoid
HCC1806 rapamycin 0 3 72
 8 3.249
0.223
0.805
0.162
0.000183
0.746
0.1
0.663
0.0382
NA
1.05
0.717
0.76
1e-05
0.657
0.1
0.68
0.0328
NA
Hs 578T Buparlisib 1
sigmoid
sigmoid
Hs578T buparlisib 1
 8 2.064
0.55
-0.579
0.308
1.29
-1.0
1.29
0.992
4.22e-07
NA
0.587
0.0401
0.759
0.587
0.0
1.31
0.988
1.94e-06
NA
Hs 578T Pictilisib 1
sigmoid
sigmoid
Hs578T pictilisib 1
 8 2.048
0.482
0.341
0.267
0.162
0.295
0.819
0.998
8.97e-09
NA
0.981
0.441
0.759
0.12
0.416
0.847
0.998
6.97e-09
NA
HCC38 GDC-0980 2 72
sigmoid
sigmoid
HCC38 apitolisib 0 2 72
 8 2.159
0.33
0.153
0.279
0.253
0.117
1.0
0.992
4.91e-07
NA
0.385
0.304
0.749
0.165
0.308
1.13
0.994
2.09e-07
NA
HCC70 WYE-125132 2 72
sigmoid
sigmoid
HCC70 WYE-132 0 2 72
 8 1.675
0.213
0.471
0.332
0.0211
0.467
1.18
0.996
6.89e-08
NA
Inf
0.598
0.744
0.0194
0.595
1.17
0.996
7.52e-08
NA
BT-549 GDC-0980 1 72
sigmoid
sigmoid
BT549 apitolisib 0 1 72
 8 1.781
0.19
0.113
0.333
0.16
0.1
1.27
0.999
4.05e-10
NA
0.328
0.352
0.744
0.132
0.347
1.31
0.999
7.05e-10
NA
BT-20 ZSTK474 2 72
sigmoid
sigmoid
BT20 ZSTK474 0 2 72
 8 1.787
0.286
-0.19
0.347
0.373
-0.234
1.46
0.992
4.53e-07
NA
0.391
0.199
0.743
0.29
0.184
1.55
0.988
1.84e-06
NA
HCC70 WYE-125132 3 72
sigmoid
sigmoid
HCC70 WYE-132 0 3 72
 8 2.417
Inf
0.592
0.246
0.0209
0.606
1.64
0.995
1.48e-07
NA
Inf
0.576
0.739
0.019
0.588
1.64
0.996
7.52e-08
NA
HCC70 Dactolisib 2 72
sigmoid
sigmoid
HCC70 dactolisib 0 2 72
 8 1.677
0.312
0.238
0.341
0.195
0.103
0.493
0.954
9.66e-05
NA
2.24
0.447
0.738
0.0858
0.419
0.56
0.954
9.8e-05
NA
BT-549 PI103 1 72
sigmoid
sigmoid
BT549 PI-103 0 1 72
 8 1.795
0.206
0.0898
0.34
0.185
0.0628
1.25
0.997
2.96e-08
NA
0.348
0.336
0.737
0.155
0.318
1.25
0.996
8.76e-08
NA
HCC70 Sirolimus 3 72
sigmoid
sigmoid
HCC70 rapamycin 0 3 72
 8 2.548
310.0
0.732
0.227
0.000433
0.63
0.1
0.676
0.034
NA
22876.0
0.693
0.736
0.000237
0.58
0.1
0.659
0.0397
NA
BT-20 PI103 3 72
sigmoid
sigmoid
BT20 PI-103 0 3 72
 8 2.496
0.373
0.0139
0.282
0.387
-0.0286
1.52
0.994
1.99e-07
NA
0.359
0.183
0.735
0.279
0.162
1.56
0.988
1.71e-06
NA
HCC70 Sirolimus 1 72
sigmoid
sigmoid
HCC70 rapamycin 0 1 72
 8 1.416
37.6
0.533
0.397
0.00426
0.298
0.1
0.742
0.0172
NA
125000000.0
0.687
0.732
0.00186
0.541
0.1
0.74
0.0175
NA
Hs 578T PI103 3
sigmoid
sigmoid
Hs578T PI-103 3
 8 2.807
0.321
0.175
0.26
0.231
0.163
1.21
0.991
8.05e-07
NA
0.232
0.225
0.729
0.145
0.239
1.39
0.986
2.82e-06
NA
HCC70 AZD-6482 3 72
sigmoid
sigmoid
HCC70 AZD6482 0 3 72
 8 2.532
1.43
0.435
0.247
0.421
0.226
0.492
0.983
4.63e-06
NA
1.13
0.431
0.729
0.208
0.286
0.5
0.982
6.2e-06
NA