Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-20 Everolimus 2 72
flat
flat
BT20 everolimus 0 2 72
8 1.785
Inf
0.426
0.574
0.0
0.426
0.01
NA
NA
0.426
Inf
0.547
0.547
0.0
0.547
0.01
NA
NA
0.547
BT-20 Everolimus 3 72
flat
flat
BT20 everolimus 0 3 72
8 2.422
Inf
0.475
0.456
0.0
0.475
0.01
0.602
0.0632
0.543
Inf
0.478
0.534
0.0
0.478
0.01
0.561
0.0844
0.534
BT-20 Pictilisib 1 72
sigmoid
sigmoid
BT20 pictilisib 0 1 72
8 2.085
1.25
0.163
0.177
5.0
-1.0
0.791
0.994
1.75e-07
NA
1.52
0.323
0.838
1.52
0.0
0.865
0.989
1.22e-06
NA
BT-20 Pictilisib 2 72
sigmoid
sigmoid
BT20 pictilisib 0 2 72
8 1.746
0.308
-0.0521
0.379
2.35
-1.0
0.54
0.791
0.00908
NA
0.634
0.272
0.712
0.634
0.0
0.6
0.716
0.0229
NA
BT-20 Pictilisib 3 72
sigmoid
sigmoid
BT20 pictilisib 0 3 72
8 2.566
0.839
0.172
0.22
0.914
-0.0483
1.09
0.954
9.59e-05
NA
0.843
0.254
0.768
0.809
0.0179
0.898
0.918
0.000551
NA
BT-20 GDC-0980 1 72
sigmoid
sigmoid
BT20 apitolisib 0 1 72
8 2.001
0.0935
-0.289
0.498
0.128
-0.251
1.29
0.994
2.71e-07
NA
0.113
0.126
0.62
0.0885
0.151
1.48
0.996
7.34e-08
NA
BT-20 GDC-0980 2 72
sigmoid
sigmoid
BT20 apitolisib 0 2 72
8 1.659
0.0456
-0.414
0.639
0.0629
-0.33
1.58
0.993
4.18e-07
NA
0.0641
0.131
0.575
0.0506
0.168
1.74
0.995
1.2e-07
NA
BT-20 GDC-0980 3 72
sigmoid
sigmoid
BT20 apitolisib 0 3 72
8 2.502
0.0976
-0.115
0.437
0.107
-0.0716
1.53
0.994
2.41e-07
NA
0.0894
0.13
0.62
0.0732
0.163
1.96
0.996
6.83e-08
NA
BT-20 Omipalisib 1 72
sigmoid
sigmoid
BT20 omipalisib 0 1 72
8 2.078
0.00617
-0.729
0.985
0.0283
-0.739
0.596
0.97
2.83e-05
NA
0.00781
0.0157
0.306
0.00685
0.0597
0.96
0.988
1.57e-06
NA
BT-20 Omipalisib 2 72
sigmoid
sigmoid
BT20 omipalisib 0 2 72
8 1.717
0.00324
-0.799
1.1
0.00361
-0.354
4.99
0.808
0.00704
NA
0.00518
0.0194
0.291
0.00429
0.111
1.34
0.968
3.16e-05
NA
BT-20 Omipalisib 3 72
sigmoid
sigmoid
BT20 omipalisib 0 3 72
8 2.586
0.00689
-0.587
0.893
0.044
-0.714
0.478
0.958
7.32e-05
NA
0.00572
0.017
0.281
0.00491
0.0669
0.945
0.983
4.7e-06
NA
BT-20 KIN001-244 1 72
flat
flat
BT20 KIN001-244 0 1 72
8 2.125
Inf
0.911
0.0401
0.0
0.911
0.01
-0.00641
1.0
0.957
Inf
0.908
0.958
0.0
0.908
0.01
-0.00745
1.0
0.955
BT-20 KIN001-244 2 72
sigmoid
sigmoid
BT20 KIN001-244 0 2 72
8 1.742
Inf
0.85
0.0644
4.47
0.713
0.316
0.721
0.0218
NA
Inf
0.873
0.945
4.51
0.757
0.309
0.715
0.0231
NA
BT-20 KIN001-244 3 72
flat
flat
BT20 KIN001-244 0 3 72
8 2.608
Inf
0.841
0.062
0.0
0.841
0.01
0.489
0.133
0.935
Inf
0.805
0.922
0.0
0.805
0.01
0.475
0.145
0.919
BT-20 MK2206 1 72
sigmoid
sigmoid
BT20 MK-2206 0 1 72
8 2.089
Inf
0.732
0.102
4.16
0.529
0.345
0.671
0.0357
NA
Inf
0.741
0.898
4.14
0.538
0.337
0.676
0.034
NA
BT-20 MK2206 2 72
sigmoid
sigmoid
BT20 MK-2206 0 2 72
8 1.739
0.823
0.0896
0.246
4.34
-1.0
0.661
0.965
4.36e-05
NA
1.47
0.348
0.806
1.47
0.0
0.715
0.947
0.000145
NA
BT-20 MK2206 3 72
sigmoid
sigmoid
BT20 MK-2206 0 3 72
8 2.449
1.73
0.252
0.12
3.23
-0.504
1.11
0.988
1.77e-06
NA
1.69
0.318
0.877
1.69
0.0
1.18
0.979
9.03e-06
NA
BT-20 PI103 1 72
sigmoid
sigmoid
BT20 PI-103 0 1 72
8 1.924
0.646
-0.0114
0.16
0.659
-0.0268
2.6
0.978
1.1e-05
NA
0.753
0.258
0.883
0.579
0.252
2.68
0.964
4.79e-05
NA
BT-20 PI103 2 72
sigmoid
sigmoid
BT20 PI-103 0 2 72
8 1.725
0.235
-0.21
0.388
0.289
-0.212
1.7
0.975
1.64e-05
NA
0.319
0.202
0.721
0.239
0.205
1.81
0.961
5.88e-05
NA
BT-20 PI103 3 72
sigmoid
sigmoid
BT20 PI-103 0 3 72
8 2.496
0.373
0.0139
0.282
0.387
-0.0286
1.52
0.994
1.99e-07
NA
0.359
0.183
0.735
0.279
0.162
1.56
0.988
1.71e-06
NA
BT-20 PIK-93 1 72
sigmoid
sigmoid
BT20 PIK-93 0 1 72
8 2.025
2.65
0.406
0.0864
6.54
-1.0
1.22
0.993
3.89e-07
NA
3.15
0.49
0.92
3.15
0.0
1.31
0.989
1.33e-06
NA
BT-20 PIK-93 2 72
sigmoid
sigmoid
BT20 PIK-93 0 2 72
8 1.798
0.792
0.155
0.286
14.1
-1.0
0.382
0.81
0.00687
NA
2.8
0.373
0.764
2.8
0.0
0.344
0.77
0.0121
NA
BT-20 PIK-93 3 72
sigmoid
sigmoid
BT20 PIK-93 0 3 72
8 2.532
2.65
0.419
0.097
7.54
-1.0
1.05
0.982
5.47e-06
NA
2.5
0.42
0.892
2.5
0.0
1.17
0.971
2.45e-05
NA
BT-20 Sirolimus 1 72
flat
flat
BT20 rapamycin 0 1 72
8 2.100
Inf
0.568
0.431
0.0
0.568
0.01
-9.89
1.0
0.568
Inf
0.6
0.601
0.0
0.6
0.01
-13.0
1.0
0.6
BT-20 Sirolimus 2 72
flat
flat
BT20 rapamycin 0 2 72
8 1.952
Inf
0.421
0.579
0.0
0.421
0.01
NA
NA
0.421
Inf
0.513
0.513
0.0
0.513
0.01
NA
NA
0.513