Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
HCC70 Dactolisib 1 72
sigmoid
sigmoid
HCC70 dactolisib 0 1 72
 8 1.400
0.0808
-0.0667
0.501
3.34
-1.0
0.295
0.963
5.02e-05
NA
0.753
0.344
0.673
0.753
0.0
0.308
0.962
5.37e-05
NA
HCC70 Dactolisib 2 72
sigmoid
sigmoid
HCC70 dactolisib 0 2 72
 8 1.677
0.312
0.238
0.341
0.195
0.103
0.493
0.954
9.66e-05
NA
2.24
0.447
0.738
0.0858
0.419
0.56
0.954
9.8e-05
NA
HCC70 Dactolisib 3 72
sigmoid
sigmoid
HCC70 dactolisib 0 3 72
 8 2.430
0.738
0.321
0.312
18.6
-0.818
0.3
0.975
1.64e-05
NA
0.688
0.365
0.675
0.635
0.0134
0.338
0.97
2.7e-05
NA
HCC70 Buparlisib 1 72
sigmoid
sigmoid
HCC70 buparlisib 0 1 72
 8 1.374
0.608
-0.494
0.231
1.27
-0.9
1.4
0.98
7.6e-06
NA
0.988
0.151
0.861
0.98
0.00578
1.46
0.973
1.91e-05
NA
HCC70 Buparlisib 2 72
sigmoid
sigmoid
HCC70 buparlisib 0 2 72
 8 1.724
0.861
-0.272
0.162
1.33
-0.556
1.71
0.989
1.21e-06
NA
1.12
0.175
0.888
1.03
0.0639
1.76
0.982
5.47e-06
NA
HCC70 Buparlisib 3 72
sigmoid
sigmoid
HCC70 buparlisib 0 3 72
 8 2.439
0.968
-0.156
0.167
1.7
-0.624
1.43
0.995
1.16e-07
NA
0.944
0.122
0.852
0.944
0.0
1.57
0.988
1.57e-06
NA
HCC70 BX-912 1 72
sigmoid
sigmoid
HCC70 BX-912 0 1 72
 8 1.436
1.08
-0.227
0.134
1.2
-0.255
3.86
0.99
1.07e-06
NA
1.35
0.256
0.916
1.14
0.242
3.87
0.986
2.78e-06
NA
HCC70 BX-912 2 72
sigmoid
sigmoid
HCC70 BX-912 0 2 72
 8 1.693
1.25
0.00257
0.0619
1.25
-0.00649
5.0
0.971
2.55e-05
NA
1.44
0.311
0.961
1.2
0.306
5.0
0.956
8.35e-05
NA
HCC70 BX-912 3 72
sigmoid
sigmoid
HCC70 BX-912 0 3 72
 8 2.465
1.26
0.174
0.0739
1.16
0.168
5.0
0.988
1.75e-06
NA
1.26
0.269
0.935
1.08
0.265
5.0
0.977
1.15e-05
NA
HCC70 Alpelisib 1 72
sigmoid
sigmoid
HCC70 alpelisib 0 1 72
 8 1.383
4.4
0.574
0.105
20.4
-1.0
0.717
0.78
0.0106
NA
11.9
0.718
0.929
11.9
0.0
0.732
0.768
0.0124
NA
HCC70 Alpelisib 2 72
flat
flat
HCC70 alpelisib 0 2 72
 8 1.799
Inf
0.748
0.0777
0.0
0.748
0.01
0.00864
0.974
0.907
Inf
0.785
0.932
0.0
0.785
0.01
0.00534
0.984
0.919
HCC70 Alpelisib 3 72
flat
flat
HCC70 alpelisib 0 3 72
 8 2.465
Inf
0.859
0.027
0.0
0.859
0.01
0.407
0.209
0.961
Inf
0.835
0.968
0.0
0.835
0.01
0.394
0.222
0.954
HCC70 CAL-101 1 72
sigmoid
sigmoid
HCC70 idelalisib 0 1 72
 8 1.384
2.78
0.485
0.0894
0.883
0.424
1.65
0.972
2.11e-05
NA
Inf
0.662
0.941
0.846
0.626
1.66
0.97
2.79e-05
NA
HCC70 CAL-101 2 72
sigmoid
sigmoid
HCC70 idelalisib 0 2 72
 8 1.738
Inf
0.62
0.0432
0.959
0.611
3.13
0.965
4.31e-05
NA
Inf
0.693
0.965
0.935
0.686
3.13
0.96
6.52e-05
NA
HCC70 CAL-101 3 72
sigmoid
sigmoid
HCC70 idelalisib 0 3 72
 8 2.510
Inf
0.724
0.0241
1.39
0.69
2.52
0.964
4.57e-05
NA
Inf
0.689
0.973
1.33
0.655
2.52
0.956
8.64e-05
NA
HCC70 Everolimus 1 72
flat
flat
HCC70 everolimus 0 1 72
 8 1.366
Inf
0.569
0.354
0.0
0.569
0.01
0.623
0.0534
0.643
Inf
0.718
0.766
0.0
0.718
0.01
0.62
0.0547
0.765
HCC70 Everolimus 2 72
flat
flat
HCC70 everolimus 0 2 72
 8 1.730
Inf
0.674
0.227
0.0
0.674
0.01
0.271
0.388
0.766
Inf
0.735
0.812
0.0
0.735
0.01
0.264
0.399
0.807
HCC70 Everolimus 3 72
sigmoid
sigmoid
HCC70 everolimus 0 3 72
 8 2.401
530906.0
0.749
0.195
0.072
0.603
0.1
0.706
0.0255
NA
381983.0
0.725
0.782
0.0137
0.59
0.1
0.706
0.0255
NA
HCC70 Pictilisib 1 72
sigmoid
sigmoid
HCC70 pictilisib 0 1 72
 8 1.409
0.408
-0.099
0.284
0.578
-0.245
1.14
0.996
7.62e-08
NA
0.888
0.325
0.816
0.477
0.261
1.19
0.995
1.2e-07
NA
HCC70 Pictilisib 2 72
sigmoid
sigmoid
HCC70 pictilisib 0 2 72
 8 1.783
0.811
0.124
0.189
0.858
-0.0372
1.27
0.973
2.08e-05
NA
1.25
0.358
0.852
0.678
0.278
1.32
0.963
5.09e-05
NA
HCC70 Pictilisib 3 72
sigmoid
sigmoid
HCC70 pictilisib 0 3 72
 8 2.450
1.32
0.305
0.102
0.938
0.225
1.76
0.983
4.73e-06
NA
1.28
0.351
0.901
0.766
0.303
1.81
0.973
2.06e-05
NA
HCC70 GDC-0980 1 72
sigmoid
sigmoid
HCC70 apitolisib 0 1 72
 8 1.350
0.211
-0.312
0.362
0.339
-0.362
1.15
0.985
3.24e-06
NA
0.441
0.237
0.779
0.266
0.236
1.26
0.985
3.31e-06
NA
HCC70 GDC-0980 2 72
sigmoid
sigmoid
HCC70 apitolisib 0 2 72
 8 1.676
0.318
-0.0849
0.284
0.451
-0.205
0.983
0.976
1.34e-05
NA
0.536
0.27
0.795
0.285
0.252
1.11
0.972
2.28e-05
NA
HCC70 GDC-0980 3 72
sigmoid
sigmoid
HCC70 apitolisib 0 3 72
 8 2.423
0.623
0.206
0.211
0.509
0.0878
0.959
0.986
2.55e-06
NA
0.568
0.293
0.792
0.283
0.266
1.09
0.981
6.41e-06
NA
HCC70 Omipalisib 1 72
sigmoid
sigmoid
HCC70 omipalisib 0 1 72
 8 1.358
0.00496
-0.785
1.14
0.0157
-0.775
0.812
0.989
1.34e-06
NA
0.0123
0.0486
0.349
0.011
0.0462
0.833
0.984
3.73e-06
NA