Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)
Data Columns
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| Name | Description | Display Name | Data Type | Unit | Precision | Readout Type | Replicate | Comments |
|---|---|---|---|---|---|---|---|---|
| AUC | area under the curve used to fit the relative cell count values for treatment versus control | AUC | Text | |||||
| ctrlCellDoublings | average number of doublings for DMSO-treated cells over the course of the assay | Cell doublings (DMSO control) | Numeric | 3 | ||||
| cellLine | cell reagent | Cell line | cell | |||||
| GEC50 | drug concentration at half of its maximal effect, based on the curve used to fit GR values for treatment versus control | GEC50 | Text | uM | ||||
| GR50 | drug concentration at which the GR value = 0.5, based on the the curve used to fit GR values for treatment versus control | GR50 | Text | uM | ||||
| IC50 | drug concentration producing 50% relative cell count versus DMSO control | IC50 | Text | uM | ||||
| EC50 | drug concentration producing half of its maximal effect, based on the curve used to fit relative cell counts for treatment versus control | EC50 | Text | uM | ||||
| Einf | estimated maximal efficacy based on the asymptote of the curve used to fit relative cell counts for treatment versus control | Einf | Text | |||||
| replicate | experimental replicate number | Experimental replicate | Numeric | 0 | ||||
| experiment | experiment name based on cell line, drug and experimental replicate | Experiment name | Text | |||||
| Emax | maximal measured efficacy in terms of % relative cell count versus DMSO control | Emax | Text | |||||
| concentrationPoints | number of drug concentrations evaluated (½ log dilution series) | Number of concentrations | Numeric | 0 | ||||
| flatFitGr | r^2 value for the flat fit for GR values (when a sigmoid cannot be fit) | R-squared flat fit (GR values) | Text | |||||
| flatFitRelCell | r^2 value for the flat fit for relative cell counts (when a sigmoid cannot be fit) | R-squared flat fit (relative cell counts) | Text | |||||
| r2Gr | r^2 value for the sigmoid curve used to fit GR values for treatment versus control | R-squared sigmoid fit (GR values) | Text | |||||
| r2RelCell | r^2 value for the sigmoid curve used to fit relative cell counts for treatment versus control | R-squared sigmoid fit (relative cell counts) | Text | |||||
| treatment | small molecule perturbagen | Drug name | small_molecule | |||||
| pvalRelCell | statistical significance of sigmoid curve fit based on an F-test | P-value sigmoid fit (relative cell counts) | Text | |||||
| pvalGr | statistical significance of the sigmoid curve fit based on an F-test | P-value sigmoid fit (GR values) | Text | |||||
| grAoc | the area over the curve used to fit the GR values for treatment versus control (integral of 1–GR over the range of concentrations tested) | GR_AOC | Text | |||||
| GRinf | the estimated effect of the drug at infinite concentration, based on the asymptote of the curve used to fit GR values for treatment versus control | GRinf | Text | |||||
| GRmax | the GR value at the highest concentration of drug tested | GRmax | Text | |||||
| hGr | the hill coefficient (slope) of the curve used to fit GR values for treatment versus control | Hill slope (GR values) | Text | |||||
| h | the hill coefficient (slope) of the curve used to fit relative cell counts for treatment versus control | Hill slope (relative cell counts) | Text | |||||
| time | timepoint at which treatment response was analyzed | Timepoint | Numeric | hr | 0 |