Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | ZSTK474 | 3 | 72 | 1.0 | 2470.8 | 3243.8 | 1180.5 | 0.0 | 0.659 | 0.762 | 1.458 | HCC38 ZSTK474 0 3 72 |
| HCC38 | ZSTK474 | 3 | 72 | 0.32 | 2743.5 | 3243.8 | 1180.5 | -0.495 | 0.783 | 0.846 | 1.458 | HCC38 ZSTK474 0 3 72 |
| HCC38 | ZSTK474 | 3 | 72 | 0.1 | 2993.0 | 3243.8 | 1180.5 | -1.0 | 0.893 | 0.923 | 1.458 | HCC38 ZSTK474 0 3 72 |
| HCC38 | ZSTK474 | 3 | 72 | 0.032 | 3190.8 | 3243.8 | 1180.5 | -1.49 | 0.978 | 0.984 | 1.458 | HCC38 ZSTK474 0 3 72 |
| HCC38 | ZSTK474 | 3 | 72 | 0.01 | 3256.5 | 3243.8 | 1180.5 | -2.0 | 1.010 | 1.000 | 1.458 | HCC38 ZSTK474 0 3 72 |
| HCC38 | ZSTK474 | 3 | 72 | 0.0032 | 3145.5 | 3243.8 | 1180.5 | -2.49 | 0.958 | 0.970 | 1.458 | HCC38 ZSTK474 0 3 72 |
| HCC38 | ZSTK474 | 3 | 72 | 0.001 | 3261.0 | 3243.8 | 1180.5 | -3.0 | 1.010 | 1.010 | 1.458 | HCC38 ZSTK474 0 3 72 |
| BT-549 | ZSTK474 | 1 | 72 | 3.2 | 2228.3 | 5649.0 | 1554.9 | 0.505 | 0.213 | 0.394 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 1.0 | 2875.0 | 5649.0 | 1554.9 | 0.0 | 0.391 | 0.509 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.32 | 3782.8 | 5649.0 | 1554.9 | -0.495 | 0.612 | 0.670 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.1 | 4613.8 | 5649.0 | 1554.9 | -1.0 | 0.794 | 0.817 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.032 | 5268.8 | 5649.0 | 1554.9 | -1.49 | 0.926 | 0.933 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.01 | 5438.8 | 5649.0 | 1554.9 | -2.0 | 0.960 | 0.963 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.0032 | 5402.5 | 5649.0 | 1554.9 | -2.49 | 0.953 | 0.956 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.001 | 5313.0 | 5649.0 | 1554.9 | -3.0 | 0.935 | 0.941 | 1.861 | BT549 ZSTK474 0 1 72 |
| HCC38 | ZSTK474 | 2 | 72 | 3.2 | 1464.3 | 3291.0 | 690.5 | 0.505 | 0.396 | 0.445 | 2.253 | HCC38 ZSTK474 0 2 72 |
| HCC38 | ZSTK474 | 2 | 72 | 1.0 | 1966.3 | 3291.0 | 690.5 | 0.0 | 0.591 | 0.597 | 2.253 | HCC38 ZSTK474 0 2 72 |
| HCC38 | ZSTK474 | 2 | 72 | 0.32 | 2201.3 | 3291.0 | 690.5 | -0.495 | 0.673 | 0.669 | 2.253 | HCC38 ZSTK474 0 2 72 |
| HCC38 | ZSTK474 | 2 | 72 | 0.1 | 2849.8 | 3291.0 | 690.5 | -1.0 | 0.876 | 0.866 | 2.253 | HCC38 ZSTK474 0 2 72 |
| HCC38 | ZSTK474 | 2 | 72 | 0.032 | 2978.8 | 3291.0 | 690.5 | -1.49 | 0.913 | 0.905 | 2.253 | HCC38 ZSTK474 0 2 72 |
| HCC38 | ZSTK474 | 2 | 72 | 0.01 | 3051.3 | 3291.0 | 690.5 | -2.0 | 0.934 | 0.927 | 2.253 | HCC38 ZSTK474 0 2 72 |
| HCC38 | ZSTK474 | 2 | 72 | 0.0032 | 3131.3 | 3291.0 | 690.5 | -2.49 | 0.956 | 0.951 | 2.253 | HCC38 ZSTK474 0 2 72 |
| HCC38 | ZSTK474 | 2 | 72 | 0.001 | 3202.3 | 3291.0 | 690.5 | -3.0 | 0.976 | 0.973 | 2.253 | HCC38 ZSTK474 0 2 72 |
| Hs 578T | ZSTK474 | 2 | 72 | 3.2 | 968.8 | 3668.0 | 624.7 | 0.505 | 0.187 | 0.264 | 2.554 | Hs578T ZSTK474 2 |
| Hs 578T | ZSTK474 | 2 | 72 | 1.0 | 1628.5 | 3668.0 | 624.7 | 0.0 | 0.455 | 0.444 | 2.554 | Hs578T ZSTK474 2 |