Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | XL147 | 3 | 72 | 0.001 | 2958.8 | 3677.3 | 586.9 | -3.0 | 0.842 | 0.805 | 2.647 | BT20 XL147 0 3 |
| HCC1806 | XL147 | 3 | 72 | 3.2 | 12161.5 | 11581.0 | 1273.3 | 0.505 | 1.030 | 1.050 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | XL147 | 3 | 72 | 1.0 | 11919.8 | 11581.0 | 1273.3 | 0.0 | 1.020 | 1.030 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | XL147 | 3 | 72 | 0.32 | 11645.5 | 11581.0 | 1273.3 | -0.495 | 1.000 | 1.010 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | XL147 | 3 | 72 | 0.1 | 11258.8 | 11581.0 | 1273.3 | -1.0 | 0.982 | 0.972 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | XL147 | 3 | 72 | 0.032 | 11500.3 | 11581.0 | 1273.3 | -1.49 | 0.996 | 0.993 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | XL147 | 3 | 72 | 0.01 | 11593.8 | 11581.0 | 1273.3 | -2.0 | 1.000 | 1.000 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | XL147 | 3 | 72 | 0.0032 | 11345.3 | 11581.0 | 1273.3 | -2.49 | 0.987 | 0.980 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC1806 | XL147 | 3 | 72 | 0.001 | 11248.3 | 11581.0 | 1273.3 | -3.0 | 0.982 | 0.971 | 3.185 | HCC1806 XL147 0 3 72 |
| HCC38 | XL147 | 1 | 72 | 3.2 | 4313.0 | 4362.8 | 1295.5 | 0.505 | 0.987 | 0.989 | 1.752 | HCC38 XL147 0 1 72 |
| HCC38 | XL147 | 1 | 72 | 1.0 | 4168.0 | 4362.8 | 1295.5 | 0.0 | 0.949 | 0.955 | 1.752 | HCC38 XL147 0 1 72 |
| HCC38 | XL147 | 1 | 72 | 0.32 | 4187.3 | 4362.8 | 1295.5 | -0.495 | 0.954 | 0.960 | 1.752 | HCC38 XL147 0 1 72 |
| HCC38 | XL147 | 1 | 72 | 0.1 | 4418.0 | 4362.8 | 1295.5 | -1.0 | 1.010 | 1.010 | 1.752 | HCC38 XL147 0 1 72 |
| HCC38 | XL147 | 1 | 72 | 0.032 | 4278.3 | 4362.8 | 1295.5 | -1.49 | 0.978 | 0.981 | 1.752 | HCC38 XL147 0 1 72 |
| HCC38 | XL147 | 1 | 72 | 0.01 | 4253.5 | 4362.8 | 1295.5 | -2.0 | 0.971 | 0.975 | 1.752 | HCC38 XL147 0 1 72 |
| HCC38 | XL147 | 1 | 72 | 0.0032 | 4326.5 | 4362.8 | 1295.5 | -2.49 | 0.990 | 0.992 | 1.752 | HCC38 XL147 0 1 72 |
| HCC38 | XL147 | 1 | 72 | 0.001 | 4140.8 | 4362.8 | 1295.5 | -3.0 | 0.941 | 0.949 | 1.752 | HCC38 XL147 0 1 72 |
| BT-549 | XL147 | 3 | 72 | 3.2 | 3779.0 | 4015.3 | 1175.8 | 0.505 | 0.933 | 0.941 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 1.0 | 3918.0 | 4015.3 | 1175.8 | 0.0 | 0.973 | 0.976 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 0.32 | 3977.8 | 4015.3 | 1175.8 | -0.495 | 0.989 | 0.991 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 0.1 | 3893.8 | 4015.3 | 1175.8 | -1.0 | 0.966 | 0.970 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 0.032 | 3899.3 | 4015.3 | 1175.8 | -1.49 | 0.967 | 0.971 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 0.01 | 3927.0 | 4015.3 | 1175.8 | -2.0 | 0.975 | 0.978 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 0.0032 | 3813.5 | 4015.3 | 1175.8 | -2.49 | 0.943 | 0.950 | 1.772 | BT549 XL147 0 3 72 |
| BT-549 | XL147 | 3 | 72 | 0.001 | 3846.0 | 4015.3 | 1175.8 | -3.0 | 0.952 | 0.958 | 1.772 | BT549 XL147 0 3 72 |