Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | KIN001-244 | 1 | 72 | 0.1 | 6567.5 | 6295.0 | 1443.3 | -1.0 | 1.040 | 1.040 | 2.125 | BT20 KIN001-244 0 1 |
| BT-549 | AS605240 | 1 | 72 | 0.01 | 5341.5 | 5429.5 | 1554.9 | -2.0 | 0.982 | 0.984 | 1.804 | BT549 AS605240 0 1 72 |
| BT-20 | KIN001-244 | 1 | 72 | 0.32 | 6065.5 | 6295.0 | 1443.3 | -0.495 | 0.965 | 0.964 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | Alpelisib | 1 | 72 | 0.01 | 6056.3 | 6091.5 | 1443.3 | -2.0 | 0.994 | 0.994 | 2.077 | BT20 BYL719 0 1 |
| BT-20 | KIN001-244 | 1 | 72 | 1.0 | 5975.3 | 6295.0 | 1443.3 | 0.0 | 0.952 | 0.949 | 2.125 | BT20 KIN001-244 0 1 |
| BT-549 | AS605240 | 1 | 72 | 1.0 | 5082.5 | 5429.5 | 1554.9 | 0.0 | 0.928 | 0.936 | 1.804 | BT549 AS605240 0 1 72 |
| BT-20 | KIN001-244 | 1 | 72 | 3.2 | 5716.5 | 6295.0 | 1443.3 | 0.505 | 0.911 | 0.908 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | Alpelisib | 1 | 72 | 0.032 | 5912.0 | 6091.5 | 1443.3 | -1.49 | 0.971 | 0.971 | 2.077 | BT20 BYL719 0 1 |
| BT-20 | MK2206 | 1 | 72 | 0.001 | 5632.5 | 6138.5 | 1443.3 | -3.0 | 0.919 | 0.918 | 2.089 | BT20 MK2206 0 1 |
| BT-20 | AZD-6482 | 1 | 72 | 0.1 | 5531.0 | 5948.8 | 1443.3 | -1.0 | 0.930 | 0.930 | 2.043 | BT20 AZD6482 0 1 |
| BT-20 | MK2206 | 1 | 72 | 0.0032 | 5903.0 | 6138.5 | 1443.3 | -2.49 | 0.963 | 0.962 | 2.089 | BT20 MK2206 0 1 |
| BT-20 | Alpelisib | 1 | 72 | 0.1 | 5660.0 | 6091.5 | 1443.3 | -1.0 | 0.931 | 0.929 | 2.077 | BT20 BYL719 0 1 |
| BT-20 | MK2206 | 1 | 72 | 0.01 | 6080.5 | 6138.5 | 1443.3 | -2.0 | 0.991 | 0.991 | 2.089 | BT20 MK2206 0 1 |
| BT-549 | AZD-6482 | 1 | 72 | 1.0 | 4299.3 | 5406.8 | 1554.9 | 0.0 | 0.761 | 0.795 | 1.798 | BT549 AZD6482 0 1 72 |
| BT-20 | MK2206 | 1 | 72 | 0.032 | 5766.3 | 6138.5 | 1443.3 | -1.49 | 0.941 | 0.939 | 2.089 | BT20 MK2206 0 1 |
| BT-20 | Alpelisib | 1 | 72 | 0.32 | 5140.8 | 6091.5 | 1443.3 | -0.495 | 0.843 | 0.844 | 2.077 | BT20 BYL719 0 1 |
| BT-20 | MK2206 | 1 | 72 | 0.1 | 5642.5 | 6138.5 | 1443.3 | -1.0 | 0.921 | 0.919 | 2.089 | BT20 MK2206 0 1 |
| BT-549 | AZD8055 | 1 | 72 | 0.01 | 4136.8 | 5342.3 | 1554.9 | -2.0 | 0.732 | 0.774 | 1.781 | BT549 AZD8055 0 1 72 |
| BT-20 | MK2206 | 1 | 72 | 0.32 | 5295.3 | 6138.5 | 1443.3 | -0.495 | 0.863 | 0.863 | 2.089 | BT20 MK2206 0 1 |
| BT-20 | Alpelisib | 1 | 72 | 1.0 | 3559.0 | 6091.5 | 1443.3 | 0.0 | 0.544 | 0.584 | 2.077 | BT20 BYL719 0 1 |
| BT-20 | MK2206 | 1 | 72 | 1.0 | 4545.8 | 6138.5 | 1443.3 | 0.0 | 0.732 | 0.741 | 2.089 | BT20 MK2206 0 1 |
| BT-549 | AZD8055 | 1 | 72 | 1.0 | 2083.3 | 5342.3 | 1554.9 | 0.0 | 0.179 | 0.390 | 1.781 | BT549 AZD8055 0 1 72 |
| BT-20 | MK2206 | 1 | 72 | 3.2 | 5077.7 | 6138.5 | 1443.3 | 0.505 | 0.826 | 0.827 | 2.089 | BT20 MK2206 0 1 |
| BT-549 | Buparlisib | 1 | 72 | 0.001 | 5446.8 | 5555.8 | 1554.9 | -3.0 | 0.979 | 0.980 | 1.837 | BT549 BKM120 0 1 72 |
| BT-549 | Dactolisib | 1 | 72 | 3.2 | 1533.0 | 5568.8 | 1554.9 | 0.505 | -0.008 | 0.275 | 1.840 | BT549 BEZ235 0 1 72 |