Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Pictilisib | 1 | 72 | 0.1 | 5515.0 | 6125.0 | 1443.3 | -1.0 | 0.902 | 0.900 | 2.085 | BT20 GDC0941 0 1 |
| BT-20 | Pictilisib | 1 | 72 | 0.32 | 4881.5 | 6125.0 | 1443.3 | -0.495 | 0.794 | 0.797 | 2.085 | BT20 GDC0941 0 1 |
| BT-20 | Pictilisib | 1 | 72 | 1.0 | 3772.0 | 6125.0 | 1443.3 | 0.0 | 0.585 | 0.616 | 2.085 | BT20 GDC0941 0 1 |
| BT-20 | Pictilisib | 1 | 72 | 3.2 | 1978.8 | 6125.0 | 1443.3 | 0.505 | 0.163 | 0.323 | 2.085 | BT20 GDC0941 0 1 |
| BT-20 | GDC-0980 | 1 | 72 | 0.001 | 5617.0 | 5778.5 | 1443.3 | -3.0 | 0.972 | 0.972 | 2.001 | BT20 GDC0980 0 1 |
| BT-20 | GDC-0980 | 1 | 72 | 0.0032 | 5546.3 | 5778.5 | 1443.3 | -2.49 | 0.959 | 0.960 | 2.001 | BT20 GDC0980 0 1 |
| BT-20 | GDC-0980 | 1 | 72 | 0.01 | 5643.3 | 5778.5 | 1443.3 | -2.0 | 0.976 | 0.977 | 2.001 | BT20 GDC0980 0 1 |
| BT-20 | GDC-0980 | 1 | 72 | 0.032 | 4951.0 | 5778.5 | 1443.3 | -1.49 | 0.851 | 0.857 | 2.001 | BT20 GDC0980 0 1 |
| BT-20 | GDC-0980 | 1 | 72 | 0.1 | 3042.5 | 5778.5 | 1443.3 | -1.0 | 0.452 | 0.527 | 2.001 | BT20 GDC0980 0 1 |
| BT-20 | GDC-0980 | 1 | 72 | 0.32 | 1527.5 | 5778.5 | 1443.3 | -0.495 | 0.029 | 0.264 | 2.001 | BT20 GDC0980 0 1 |
| BT-20 | GDC-0980 | 1 | 72 | 1.0 | 1191.0 | 5778.5 | 1443.3 | 0.0 | -0.092 | 0.206 | 2.001 | BT20 GDC0980 0 1 |
| BT-20 | GDC-0980 | 1 | 72 | 3.2 | 730.3 | 5778.5 | 1443.3 | 0.505 | -0.289 | 0.126 | 2.001 | BT20 GDC0980 0 1 |
| BT-20 | Omipalisib | 1 | 72 | 0.001 | 5515.0 | 6095.3 | 1443.3 | -3.0 | 0.906 | 0.905 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | Omipalisib | 1 | 72 | 0.0032 | 4184.5 | 6095.3 | 1443.3 | -2.49 | 0.669 | 0.687 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | Omipalisib | 1 | 72 | 0.01 | 2601.0 | 6095.3 | 1443.3 | -2.0 | 0.328 | 0.427 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | Omipalisib | 1 | 72 | 0.032 | 1381.0 | 6095.3 | 1443.3 | -1.49 | -0.021 | 0.227 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | Omipalisib | 1 | 72 | 0.1 | 1000.3 | 6095.3 | 1443.3 | -1.0 | -0.162 | 0.164 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | Omipalisib | 1 | 72 | 0.32 | 819.0 | 6095.3 | 1443.3 | -0.495 | -0.239 | 0.134 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | Omipalisib | 1 | 72 | 1.0 | 262.3 | 6095.3 | 1443.3 | 0.0 | -0.560 | 0.043 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | Omipalisib | 1 | 72 | 3.2 | 95.5 | 6095.3 | 1443.3 | 0.505 | -0.729 | 0.016 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | KIN001-244 | 1 | 72 | 0.001 | 6021.5 | 6295.0 | 1443.3 | -3.0 | 0.959 | 0.957 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | KIN001-244 | 1 | 72 | 0.0032 | 5775.0 | 6295.0 | 1443.3 | -2.49 | 0.920 | 0.917 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | KIN001-244 | 1 | 72 | 0.01 | 6085.0 | 6295.0 | 1443.3 | -2.0 | 0.968 | 0.967 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | KIN001-244 | 1 | 72 | 0.032 | 5891.5 | 6295.0 | 1443.3 | -1.49 | 0.939 | 0.936 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | AS605240 | 1 | 72 | 0.001 | 5834.8 | 6371.0 | 1443.3 | -3.0 | 0.920 | 0.916 | 2.142 | BT20 AS605240 0 1 |