Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | WYE-125132 | 1 | 72 | 3.2 | 1936.5 | 5366.3 | 1554.9 | 0.505 | 0.131 | 0.361 | 1.787 | BT549 WYE125132 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 0.001 | 4921.8 | 5624.3 | 1554.9 | -3.0 | 0.861 | 0.875 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 0.0032 | 5444.0 | 5624.3 | 1554.9 | -2.49 | 0.965 | 0.968 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 0.01 | 5568.8 | 5624.3 | 1554.9 | -2.0 | 0.989 | 0.990 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 0.032 | 5383.3 | 5624.3 | 1554.9 | -1.49 | 0.953 | 0.957 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 0.1 | 5584.3 | 5624.3 | 1554.9 | -1.0 | 0.992 | 0.993 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 0.32 | 5476.0 | 5624.3 | 1554.9 | -0.495 | 0.971 | 0.974 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 1.0 | 5410.8 | 5624.3 | 1554.9 | 0.0 | 0.959 | 0.962 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | XL147 | 1 | 72 | 3.2 | 5318.0 | 5624.3 | 1554.9 | 0.505 | 0.941 | 0.946 | 1.855 | BT549 XL147 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.001 | 5313.0 | 5649.0 | 1554.9 | -3.0 | 0.935 | 0.941 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.0032 | 5402.5 | 5649.0 | 1554.9 | -2.49 | 0.953 | 0.956 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.01 | 5438.8 | 5649.0 | 1554.9 | -2.0 | 0.960 | 0.963 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.032 | 5268.8 | 5649.0 | 1554.9 | -1.49 | 0.926 | 0.933 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.1 | 4613.8 | 5649.0 | 1554.9 | -1.0 | 0.794 | 0.817 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 0.32 | 3782.8 | 5649.0 | 1554.9 | -0.495 | 0.612 | 0.670 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 1.0 | 2875.0 | 5649.0 | 1554.9 | 0.0 | 0.391 | 0.509 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-549 | ZSTK474 | 1 | 72 | 3.2 | 2228.3 | 5649.0 | 1554.9 | 0.505 | 0.213 | 0.394 | 1.861 | BT549 ZSTK474 0 1 72 |
| BT-20 | ZSTK474 | 1 | 72 | 3.2 | 1504.8 | 5537.8 | 1443.3 | 0.505 | 0.022 | 0.272 | 1.940 | BT20 ZSTK474 0 1 |
| BT-20 | BX-912 | 1 | 72 | 3.2 | 4618.5 | 6155.0 | 1443.3 | 0.505 | 0.743 | 0.750 | 2.092 | BT20 BX912 0 1 |
| HCC38 | AS605240 | 1 | 72 | 0.32 | 3883.8 | 4340.3 | 1295.5 | -0.495 | 0.877 | 0.895 | 1.744 | HCC38 AS605240 0 1 72 |
| BT-20 | Omipalisib | 1 | 72 | 3.2 | 95.5 | 6095.3 | 1443.3 | 0.505 | -0.729 | 0.016 | 2.078 | BT20 GSK458 0 1 |
| HCC70 | AZD-6482 | 1 | 72 | 0.001 | 3327.3 | 3304.5 | 1279.8 | -3.0 | 1.010 | 1.010 | 1.368 | HCC70 AZD6482 0 1 72 |
| HCC70 | AZD-6482 | 1 | 72 | 0.01 | 2660.3 | 3304.5 | 1279.8 | -2.0 | 0.707 | 0.805 | 1.368 | HCC70 AZD6482 0 1 72 |
| HCC1806 | AS605240 | 1 | 72 | 1.0 | 10421.8 | 11546.3 | 1742.8 | 0.0 | 0.926 | 0.903 | 2.728 | HCC1806 AS605240 0 1 72 |
| HCC1806 | AS605240 | 1 | 72 | 0.32 | 11293.3 | 11546.3 | 1742.8 | -0.495 | 0.984 | 0.978 | 2.728 | HCC1806 AS605240 0 1 72 |