Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | GDC-0980 | 1 | 72 | 0.32 | 2708.3 | 5343.8 | 1554.9 | -0.495 | 0.366 | 0.507 | 1.781 | BT549 GDC0980 0 1 72 |
| BT-549 | GDC-0980 | 1 | 72 | 3.2 | 1881.0 | 5343.8 | 1554.9 | 0.505 | 0.113 | 0.352 | 1.781 | BT549 GDC0980 0 1 72 |
| BT-549 | GDC-0980 | 1 | 72 | 1.0 | 2114.8 | 5343.8 | 1554.9 | 0.0 | 0.188 | 0.396 | 1.781 | BT549 GDC0980 0 1 72 |
| BT-20 | PI103 | 1 | 72 | 3.2 | 1411.8 | 5476.0 | 1443.3 | 0.505 | -0.011 | 0.258 | 1.924 | BT20 PI103 0 1 |
| BT-20 | Dactolisib | 1 | 72 | 0.32 | 1891.3 | 5998.3 | 1443.3 | -0.495 | 0.141 | 0.315 | 2.055 | BT20 BEZ235 0 1 |
| BT-20 | CAL-101 | 1 | 72 | 0.032 | 6025.0 | 6240.0 | 1443.3 | -1.49 | 0.967 | 0.966 | 2.112 | BT20 CAL101 0 1 |
| BT-549 | KIN001-244 | 1 | 72 | 0.0032 | 5282.0 | 5422.3 | 1554.9 | -2.49 | 0.971 | 0.974 | 1.802 | BT549 KIN001-244 0 1 72 |
| BT-20 | PIK-93 | 1 | 72 | 0.001 | 5862.8 | 5875.8 | 1443.3 | -3.0 | 0.998 | 0.998 | 2.025 | BT20 PIK93 0 1 |
| BT-549 | Omipalisib | 1 | 72 | 0.32 | 1638.5 | 5372.5 | 1554.9 | -0.495 | 0.030 | 0.305 | 1.789 | BT549 GSK458 0 1 72 |
| BT-20 | AZD-6482 | 1 | 72 | 1.0 | 3655.0 | 5948.8 | 1443.3 | 0.0 | 0.576 | 0.614 | 2.043 | BT20 AZD6482 0 1 |
| BT-549 | Omipalisib | 1 | 72 | 1.0 | 1268.8 | 5372.5 | 1554.9 | 0.0 | -0.107 | 0.236 | 1.789 | BT549 GSK458 0 1 72 |
| BT-20 | PIK-93 | 1 | 72 | 0.0032 | 5799.0 | 5875.8 | 1443.3 | -2.49 | 0.987 | 0.987 | 2.025 | BT20 PIK93 0 1 |
| BT-549 | KIN001-244 | 1 | 72 | 0.1 | 5420.0 | 5422.3 | 1554.9 | -1.0 | 1.000 | 1.000 | 1.802 | BT549 KIN001-244 0 1 72 |
| BT-20 | CAL-101 | 1 | 72 | 0.1 | 6019.8 | 6240.0 | 1443.3 | -1.0 | 0.966 | 0.965 | 2.112 | BT20 CAL101 0 1 |
| BT-549 | KIN001-244 | 1 | 72 | 0.01 | 5363.0 | 5422.3 | 1554.9 | -2.0 | 0.988 | 0.989 | 1.802 | BT549 KIN001-244 0 1 72 |
| BT-20 | PIK-93 | 1 | 72 | 0.01 | 5717.0 | 5875.8 | 1443.3 | -2.0 | 0.973 | 0.973 | 2.025 | BT20 PIK93 0 1 |
| BT-549 | KIN001-244 | 1 | 72 | 0.32 | 5191.0 | 5422.3 | 1554.9 | -0.495 | 0.952 | 0.957 | 1.802 | BT549 KIN001-244 0 1 72 |
| BT-549 | KIN001-244 | 1 | 72 | 3.2 | 4812.3 | 5422.3 | 1554.9 | 0.505 | 0.872 | 0.888 | 1.802 | BT549 KIN001-244 0 1 72 |
| BT-549 | KIN001-244 | 1 | 72 | 1.0 | 5123.0 | 5422.3 | 1554.9 | 0.0 | 0.938 | 0.945 | 1.802 | BT549 KIN001-244 0 1 72 |
| BT-20 | PIK-93 | 1 | 72 | 0.032 | 5933.3 | 5875.8 | 1443.3 | -1.49 | 1.010 | 1.010 | 2.025 | BT20 PIK93 0 1 |
| BT-20 | Dactolisib | 1 | 72 | 1.0 | 1253.8 | 5998.3 | 1443.3 | 0.0 | -0.066 | 0.209 | 2.055 | BT20 BEZ235 0 1 |
| BT-20 | CAL-101 | 1 | 72 | 0.32 | 6047.5 | 6240.0 | 1443.3 | -0.495 | 0.971 | 0.969 | 2.112 | BT20 CAL101 0 1 |
| BT-549 | MK2206 | 1 | 72 | 0.032 | 4974.3 | 5457.0 | 1554.9 | -1.49 | 0.900 | 0.912 | 1.811 | BT549 MK2206 0 1 72 |
| HCC38 | PI103 | 1 | 72 | 0.032 | 4356.0 | 4454.3 | 1295.5 | -1.49 | 0.975 | 0.978 | 1.782 | HCC38 PI103 0 1 72 |
| HCC38 | PI103 | 1 | 72 | 0.01 | 4350.3 | 4454.3 | 1295.5 | -2.0 | 0.974 | 0.977 | 1.782 | HCC38 PI103 0 1 72 |