Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TGX221 | 3 | 72 | 0.001 | 2874.3 | 2844.8 | 517.3 | -3.0 | 1.010 | 1.010 | 2.459 | HCC70 TGX221 0 3 72 |
| HCC70 | TGX221 | 3 | 72 | 0.0032 | 2821.3 | 2844.8 | 517.3 | -2.49 | 0.993 | 0.992 | 2.459 | HCC70 TGX221 0 3 72 |
| HCC70 | TGX221 | 3 | 72 | 0.01 | 2977.3 | 2844.8 | 517.3 | -2.0 | 1.040 | 1.050 | 2.459 | HCC70 TGX221 0 3 72 |
| HCC70 | TGX221 | 3 | 72 | 0.032 | 2804.8 | 2844.8 | 517.3 | -1.49 | 0.989 | 0.986 | 2.459 | HCC70 TGX221 0 3 72 |
| HCC70 | TGX221 | 3 | 72 | 0.1 | 2521.5 | 2844.8 | 517.3 | -1.0 | 0.904 | 0.886 | 2.459 | HCC70 TGX221 0 3 72 |
| HCC70 | TGX221 | 3 | 72 | 0.32 | 2377.8 | 2844.8 | 517.3 | -0.495 | 0.859 | 0.836 | 2.459 | HCC70 TGX221 0 3 72 |
| HCC70 | TGX221 | 3 | 72 | 1.0 | 2028.8 | 2844.8 | 517.3 | 0.0 | 0.743 | 0.713 | 2.459 | HCC70 TGX221 0 3 72 |
| HCC70 | TGX221 | 3 | 72 | 3.2 | 1908.0 | 2844.8 | 517.3 | 0.505 | 0.700 | 0.671 | 2.459 | HCC70 TGX221 0 3 72 |
| HCC70 | Torin1 | 3 | 72 | 0.001 | 2800.3 | 2758.5 | 517.3 | -3.0 | 1.010 | 1.020 | 2.415 | HCC70 Torin1 0 3 72 |
| HCC70 | Torin1 | 3 | 72 | 0.0032 | 2624.0 | 2758.5 | 517.3 | -2.49 | 0.959 | 0.951 | 2.415 | HCC70 Torin1 0 3 72 |
| HCC70 | Torin1 | 3 | 72 | 0.01 | 2402.5 | 2758.5 | 517.3 | -2.0 | 0.889 | 0.871 | 2.415 | HCC70 Torin1 0 3 72 |
| HCC70 | Torin1 | 3 | 72 | 0.032 | 2025.8 | 2758.5 | 517.3 | -1.49 | 0.760 | 0.734 | 2.415 | HCC70 Torin1 0 3 72 |
| HCC70 | Torin1 | 3 | 72 | 0.1 | 1639.5 | 2758.5 | 517.3 | -1.0 | 0.612 | 0.594 | 2.415 | HCC70 Torin1 0 3 72 |
| HCC70 | Torin1 | 3 | 72 | 0.32 | 1547.5 | 2758.5 | 517.3 | -0.495 | 0.574 | 0.561 | 2.415 | HCC70 Torin1 0 3 72 |
| HCC70 | Torin1 | 3 | 72 | 1.0 | 1374.5 | 2758.5 | 517.3 | 0.0 | 0.499 | 0.498 | 2.415 | HCC70 Torin1 0 3 72 |
| HCC70 | Torin1 | 3 | 72 | 3.2 | 1365.5 | 2758.5 | 517.3 | 0.505 | 0.495 | 0.495 | 2.415 | HCC70 Torin1 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 0.001 | 2508.3 | 2778.8 | 517.3 | -3.0 | 0.917 | 0.903 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 0.0032 | 2205.0 | 2778.8 | 517.3 | -2.49 | 0.818 | 0.794 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 0.01 | 2073.0 | 2778.8 | 517.3 | -2.0 | 0.772 | 0.746 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 0.032 | 1853.5 | 2778.8 | 517.3 | -1.49 | 0.692 | 0.667 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 0.1 | 1454.3 | 2778.8 | 517.3 | -1.0 | 0.531 | 0.523 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 0.32 | 641.0 | 2778.8 | 517.3 | -0.495 | 0.092 | 0.231 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 1.0 | 358.5 | 2778.8 | 517.3 | 0.0 | -0.140 | 0.129 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 3.2 | 160.0 | 2778.8 | 517.3 | 0.505 | -0.384 | 0.058 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC70 | Trametinib | 3 | 72 | 0.001 | 2589.0 | 2852.5 | 517.3 | -3.0 | 0.923 | 0.908 | 2.463 | HCC70 Trametinib 0 3 72 |