Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Buparlisib | 3 | 72 | 0.32 | 2605.3 | 3388.3 | 586.9 | -0.495 | 0.803 | 0.769 | 2.529 | BT20 BKM120 0 3 |
| BT-20 | Buparlisib | 3 | 72 | 0.1 | 2951.0 | 3388.3 | 586.9 | -1.0 | 0.894 | 0.871 | 2.529 | BT20 BKM120 0 3 |
| BT-20 | Buparlisib | 3 | 72 | 0.032 | 3201.3 | 3388.3 | 586.9 | -1.49 | 0.956 | 0.945 | 2.529 | BT20 BKM120 0 3 |
| BT-20 | Buparlisib | 3 | 72 | 0.01 | 3436.8 | 3388.3 | 586.9 | -2.0 | 1.010 | 1.010 | 2.529 | BT20 BKM120 0 3 |
| BT-20 | Buparlisib | 3 | 72 | 0.0032 | 3193.5 | 3388.3 | 586.9 | -2.49 | 0.954 | 0.943 | 2.529 | BT20 BKM120 0 3 |
| BT-20 | Buparlisib | 3 | 72 | 0.001 | 3248.8 | 3388.3 | 586.9 | -3.0 | 0.967 | 0.959 | 2.529 | BT20 BKM120 0 3 |
| BT-20 | Dactolisib | 3 | 72 | 3.2 | 621.5 | 3141.3 | 586.9 | 0.505 | 0.024 | 0.198 | 2.420 | BT20 BEZ235 0 3 |
| BT-20 | Dactolisib | 3 | 72 | 1.0 | 727.5 | 3141.3 | 586.9 | 0.0 | 0.093 | 0.232 | 2.420 | BT20 BEZ235 0 3 |
| BT-20 | Dactolisib | 3 | 72 | 0.32 | 833.5 | 3141.3 | 586.9 | -0.495 | 0.156 | 0.265 | 2.420 | BT20 BEZ235 0 3 |
| BT-20 | Dactolisib | 3 | 72 | 0.1 | 959.5 | 3141.3 | 586.9 | -1.0 | 0.225 | 0.305 | 2.420 | BT20 BEZ235 0 3 |
| BT-20 | Dactolisib | 3 | 72 | 0.032 | 979.8 | 3141.3 | 586.9 | -1.49 | 0.236 | 0.312 | 2.420 | BT20 BEZ235 0 3 |
| BT-20 | Dactolisib | 3 | 72 | 0.01 | 1618.0 | 3141.3 | 586.9 | -2.0 | 0.520 | 0.515 | 2.420 | BT20 BEZ235 0 3 |
| BT-20 | Dactolisib | 3 | 72 | 0.0032 | 2424.0 | 3141.3 | 586.9 | -2.49 | 0.797 | 0.772 | 2.420 | BT20 BEZ235 0 3 |
| BT-20 | Dactolisib | 3 | 72 | 0.001 | 3041.8 | 3141.3 | 586.9 | -3.0 | 0.974 | 0.968 | 2.420 | BT20 BEZ235 0 3 |
| BT-20 | AZD8055 | 3 | 72 | 3.2 | 529.0 | 3441.0 | 586.9 | 0.505 | -0.040 | 0.154 | 2.552 | BT20 AZD8055 0 3 |
| BT-20 | AZD8055 | 3 | 72 | 1.0 | 616.8 | 3441.0 | 586.9 | 0.0 | 0.020 | 0.179 | 2.552 | BT20 AZD8055 0 3 |
| BT-20 | AZD8055 | 3 | 72 | 0.32 | 709.0 | 3441.0 | 586.9 | -0.495 | 0.077 | 0.206 | 2.552 | BT20 AZD8055 0 3 |
| BT-20 | AZD8055 | 3 | 72 | 0.1 | 1053.0 | 3441.0 | 586.9 | -1.0 | 0.257 | 0.306 | 2.552 | BT20 AZD8055 0 3 |
| BT-20 | AZD8055 | 3 | 72 | 0.032 | 1649.5 | 3441.0 | 586.9 | -1.49 | 0.499 | 0.479 | 2.552 | BT20 AZD8055 0 3 |
| BT-20 | AZD8055 | 3 | 72 | 0.01 | 2824.3 | 3441.0 | 586.9 | -2.0 | 0.851 | 0.821 | 2.552 | BT20 AZD8055 0 3 |
| BT-20 | AZD8055 | 3 | 72 | 0.0032 | 2862.0 | 3441.0 | 586.9 | -2.49 | 0.861 | 0.832 | 2.552 | BT20 AZD8055 0 3 |
| BT-20 | AZD8055 | 3 | 72 | 0.001 | 3103.8 | 3441.0 | 586.9 | -3.0 | 0.921 | 0.902 | 2.552 | BT20 AZD8055 0 3 |
| BT-20 | AZD-6482 | 3 | 72 | 3.2 | 1162.3 | 3560.8 | 586.9 | 0.505 | 0.300 | 0.326 | 2.601 | BT20 AZD6482 0 3 |
| BT-20 | AZD-6482 | 3 | 72 | 1.0 | 2162.8 | 3560.8 | 586.9 | 0.0 | 0.651 | 0.607 | 2.601 | BT20 AZD6482 0 3 |
| BT-20 | AZD-6482 | 3 | 72 | 0.32 | 2758.0 | 3560.8 | 586.9 | -0.495 | 0.813 | 0.775 | 2.601 | BT20 AZD6482 0 3 |