Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Torin1 | 1 | 72 | 1.0 | 1708.3 | 5863.3 | 1443.3 | 0.0 | 0.087 | 0.291 | 2.022 | BT20 Torin1 0 1 |
| BT-549 | BX-912 | 1 | 72 | 0.001 | 5420.5 | 5561.8 | 1554.9 | -3.0 | 0.972 | 0.975 | 1.839 | BT549 BX912 0 1 72 |
| BT-20 | Torin1 | 1 | 72 | 3.2 | 1153.3 | 5863.3 | 1443.3 | 0.505 | -0.105 | 0.197 | 2.022 | BT20 Torin1 0 1 |
| BT-20 | Pictilisib | 1 | 72 | 0.032 | 5728.5 | 6125.0 | 1443.3 | -1.49 | 0.937 | 0.935 | 2.085 | BT20 GDC0941 0 1 |
| BT-20 | Torin2 | 1 | 72 | 0.001 | 5188.5 | 5846.0 | 1443.3 | -3.0 | 0.885 | 0.888 | 2.018 | BT20 Torin2 0 1 |
| BT-20 | AZD8055 | 1 | 72 | 0.01 | 4836.5 | 5941.5 | 1443.3 | -2.0 | 0.808 | 0.814 | 2.041 | BT20 AZD8055 0 1 |
| BT-20 | Torin2 | 1 | 72 | 0.0032 | 4781.5 | 5846.0 | 1443.3 | -2.49 | 0.810 | 0.818 | 2.018 | BT20 Torin2 0 1 |
| BT-20 | Pictilisib | 1 | 72 | 0.1 | 5515.0 | 6125.0 | 1443.3 | -1.0 | 0.902 | 0.900 | 2.085 | BT20 GDC0941 0 1 |
| BT-20 | Torin2 | 1 | 72 | 0.01 | 3473.5 | 5846.0 | 1443.3 | -2.0 | 0.545 | 0.594 | 2.018 | BT20 Torin2 0 1 |
| BT-549 | Alpelisib | 1 | 72 | 0.001 | 5371.8 | 5499.0 | 1554.9 | -3.0 | 0.974 | 0.977 | 1.822 | BT549 BYL719 0 1 72 |
| BT-20 | Torin2 | 1 | 72 | 0.032 | 2533.0 | 5846.0 | 1443.3 | -1.49 | 0.321 | 0.433 | 2.018 | BT20 Torin2 0 1 |
| BT-20 | Pictilisib | 1 | 72 | 0.32 | 4881.5 | 6125.0 | 1443.3 | -0.495 | 0.794 | 0.797 | 2.085 | BT20 GDC0941 0 1 |
| BT-20 | Torin2 | 1 | 72 | 0.1 | 1832.3 | 5846.0 | 1443.3 | -1.0 | 0.126 | 0.313 | 2.018 | BT20 Torin2 0 1 |
| BT-549 | Alpelisib | 1 | 72 | 0.1 | 5280.8 | 5499.0 | 1554.9 | -1.0 | 0.956 | 0.960 | 1.822 | BT549 BYL719 0 1 72 |
| BT-20 | Torin2 | 1 | 72 | 0.32 | 1264.3 | 5846.0 | 1443.3 | -0.495 | -0.064 | 0.216 | 2.018 | BT20 Torin2 0 1 |
| BT-20 | Pictilisib | 1 | 72 | 1.0 | 3772.0 | 6125.0 | 1443.3 | 0.0 | 0.585 | 0.616 | 2.085 | BT20 GDC0941 0 1 |
| BT-20 | Torin2 | 1 | 72 | 1.0 | 457.3 | 5846.0 | 1443.3 | 0.0 | -0.434 | 0.078 | 2.018 | BT20 Torin2 0 1 |
| BT-549 | CAL-101 | 1 | 72 | 0.001 | 5321.8 | 5381.3 | 1554.9 | -3.0 | 0.988 | 0.989 | 1.791 | BT549 CAL101 0 1 72 |
| BT-20 | Torin2 | 1 | 72 | 3.2 | 96.0 | 5846.0 | 1443.3 | 0.505 | -0.739 | 0.016 | 2.018 | BT20 Torin2 0 1 |
| BT-20 | Pictilisib | 1 | 72 | 3.2 | 1978.8 | 6125.0 | 1443.3 | 0.505 | 0.163 | 0.323 | 2.085 | BT20 GDC0941 0 1 |
| BT-20 | Trametinib | 1 | 72 | 0.001 | 5603.8 | 5837.3 | 1443.3 | -3.0 | 0.960 | 0.960 | 2.016 | BT20 Trametinib 0 1 |
| BT-20 | AZD8055 | 1 | 72 | 0.032 | 3968.5 | 5941.5 | 1443.3 | -1.49 | 0.641 | 0.668 | 2.041 | BT20 AZD8055 0 1 |
| BT-20 | Trametinib | 1 | 72 | 0.0032 | 5464.0 | 5837.3 | 1443.3 | -2.49 | 0.936 | 0.936 | 2.016 | BT20 Trametinib 0 1 |
| BT-549 | Sirolimus | 1 | 72 | 0.1 | 3497.0 | 5477.5 | 1554.9 | -1.0 | 0.562 | 0.638 | 1.817 | BT549 Rapamycin 0 1 72 |
| BT-549 | Sirolimus | 1 | 72 | 0.032 | 3539.5 | 5477.5 | 1554.9 | -1.49 | 0.573 | 0.646 | 1.817 | BT549 Rapamycin 0 1 72 |