Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Everolimus | 1 | 72 | 0.1 | 3707.8 | 5781.0 | 1443.3 | -1.0 | 0.602 | 0.641 | 2.002 | BT20 Everolimus 0 1 |
| BT-20 | TGX221 | 1 | 72 | 0.01 | 5832.0 | 5723.8 | 1443.3 | -2.0 | 1.020 | 1.020 | 1.988 | BT20 TGX221 0 1 |
| BT-549 | AZD8055 | 1 | 72 | 0.001 | 5177.5 | 5342.3 | 1554.9 | -3.0 | 0.965 | 0.969 | 1.781 | BT549 AZD8055 0 1 72 |
| BT-20 | TGX221 | 1 | 72 | 0.032 | 5704.0 | 5723.8 | 1443.3 | -1.49 | 0.997 | 0.997 | 1.988 | BT20 TGX221 0 1 |
| BT-20 | Everolimus | 1 | 72 | 0.32 | 3776.0 | 5781.0 | 1443.3 | -0.495 | 0.617 | 0.653 | 2.002 | BT20 Everolimus 0 1 |
| BT-20 | TGX221 | 1 | 72 | 0.1 | 5830.8 | 5723.8 | 1443.3 | -1.0 | 1.020 | 1.020 | 1.988 | BT20 TGX221 0 1 |
| BT-549 | AZD8055 | 1 | 72 | 0.1 | 2423.5 | 5342.3 | 1554.9 | -1.0 | 0.283 | 0.454 | 1.781 | BT549 AZD8055 0 1 72 |
| BT-20 | TGX221 | 1 | 72 | 0.32 | 5838.0 | 5723.8 | 1443.3 | -0.495 | 1.020 | 1.020 | 1.988 | BT20 TGX221 0 1 |
| BT-20 | Everolimus | 1 | 72 | 1.0 | 3532.8 | 5781.0 | 1443.3 | 0.0 | 0.564 | 0.611 | 2.002 | BT20 Everolimus 0 1 |
| BT-20 | TGX221 | 1 | 72 | 1.0 | 5819.3 | 5723.8 | 1443.3 | 0.0 | 1.020 | 1.020 | 1.988 | BT20 TGX221 0 1 |
| BT-549 | Dactolisib | 1 | 72 | 0.001 | 5005.5 | 5568.8 | 1554.9 | -3.0 | 0.887 | 0.899 | 1.840 | BT549 BEZ235 0 1 72 |
| BT-20 | TGX221 | 1 | 72 | 3.2 | 5857.5 | 5723.8 | 1443.3 | 0.505 | 1.020 | 1.020 | 1.988 | BT20 TGX221 0 1 |
| BT-20 | Everolimus | 1 | 72 | 3.2 | 3453.3 | 5781.0 | 1443.3 | 0.505 | 0.546 | 0.597 | 2.002 | BT20 Everolimus 0 1 |
| BT-20 | Torin1 | 1 | 72 | 0.001 | 5232.8 | 5863.3 | 1443.3 | -3.0 | 0.891 | 0.892 | 2.022 | BT20 Torin1 0 1 |
| BT-20 | AZD8055 | 1 | 72 | 0.0032 | 5387.5 | 5941.5 | 1443.3 | -2.49 | 0.906 | 0.907 | 2.041 | BT20 AZD8055 0 1 |
| BT-20 | Torin1 | 1 | 72 | 0.0032 | 5036.3 | 5863.3 | 1443.3 | -2.49 | 0.855 | 0.859 | 2.022 | BT20 Torin1 0 1 |
| BT-20 | Pictilisib | 1 | 72 | 0.001 | 5849.5 | 6125.0 | 1443.3 | -3.0 | 0.956 | 0.955 | 2.085 | BT20 GDC0941 0 1 |
| BT-20 | Torin1 | 1 | 72 | 0.01 | 4237.5 | 5863.3 | 1443.3 | -2.0 | 0.703 | 0.723 | 2.022 | BT20 Torin1 0 1 |
| BT-549 | Dactolisib | 1 | 72 | 3.2 | 1533.0 | 5568.8 | 1554.9 | 0.505 | -0.008 | 0.275 | 1.840 | BT549 BEZ235 0 1 72 |
| BT-20 | Torin1 | 1 | 72 | 0.032 | 3317.0 | 5863.3 | 1443.3 | -1.49 | 0.509 | 0.566 | 2.022 | BT20 Torin1 0 1 |
| BT-20 | Pictilisib | 1 | 72 | 0.0032 | 6083.5 | 6125.0 | 1443.3 | -2.49 | 0.993 | 0.993 | 2.085 | BT20 GDC0941 0 1 |
| BT-20 | Torin1 | 1 | 72 | 0.1 | 2475.0 | 5863.3 | 1443.3 | -1.0 | 0.306 | 0.422 | 2.022 | BT20 Torin1 0 1 |
| BT-549 | Buparlisib | 1 | 72 | 0.032 | 5221.0 | 5555.8 | 1554.9 | -1.49 | 0.933 | 0.940 | 1.837 | BT549 BKM120 0 1 72 |
| BT-549 | MK2206 | 1 | 72 | 0.032 | 4974.3 | 5457.0 | 1554.9 | -1.49 | 0.900 | 0.912 | 1.811 | BT549 MK2206 0 1 72 |
| BT-549 | MK2206 | 1 | 72 | 0.01 | 5011.5 | 5457.0 | 1554.9 | -2.0 | 0.908 | 0.918 | 1.811 | BT549 MK2206 0 1 72 |