Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | PIK-93 | 3 | 72 | 0.01 | 2884.0 | 3077.8 | 1180.5 | -2.0 | 0.908 | 0.937 | 1.382 | HCC38 PIK93 0 3 72 |
| HCC38 | PIK-93 | 3 | 72 | 0.0032 | 3085.5 | 3077.8 | 1180.5 | -2.49 | 1.000 | 1.000 | 1.382 | HCC38 PIK93 0 3 72 |
| HCC38 | PIK-93 | 3 | 72 | 0.001 | 3163.5 | 3077.8 | 1180.5 | -3.0 | 1.040 | 1.030 | 1.382 | HCC38 PIK93 0 3 72 |
| HCC38 | PI103 | 3 | 72 | 3.2 | 1384.8 | 3295.0 | 1180.5 | 0.505 | 0.114 | 0.420 | 1.481 | HCC38 PI103 0 3 72 |
| HCC38 | PI103 | 3 | 72 | 1.0 | 2311.5 | 3295.0 | 1180.5 | 0.0 | 0.574 | 0.702 | 1.481 | HCC38 PI103 0 3 72 |
| HCC38 | PI103 | 3 | 72 | 0.32 | 2953.3 | 3295.0 | 1180.5 | -0.495 | 0.857 | 0.896 | 1.481 | HCC38 PI103 0 3 72 |
| HCC38 | PI103 | 3 | 72 | 0.1 | 3147.3 | 3295.0 | 1180.5 | -1.0 | 0.939 | 0.955 | 1.481 | HCC38 PI103 0 3 72 |
| HCC38 | PI103 | 3 | 72 | 0.032 | 3206.0 | 3295.0 | 1180.5 | -1.49 | 0.963 | 0.973 | 1.481 | HCC38 PI103 0 3 72 |
| HCC38 | PI103 | 3 | 72 | 0.01 | 3371.5 | 3295.0 | 1180.5 | -2.0 | 1.030 | 1.020 | 1.481 | HCC38 PI103 0 3 72 |
| HCC38 | PI103 | 3 | 72 | 0.0032 | 3105.3 | 3295.0 | 1180.5 | -2.49 | 0.921 | 0.942 | 1.481 | HCC38 PI103 0 3 72 |
| HCC38 | PI103 | 3 | 72 | 0.001 | 3213.8 | 3295.0 | 1180.5 | -3.0 | 0.967 | 0.975 | 1.481 | HCC38 PI103 0 3 72 |
| HCC38 | MK2206 | 3 | 72 | 3.2 | 2602.0 | 3214.0 | 1180.5 | 0.505 | 0.728 | 0.810 | 1.445 | HCC38 MK2206 0 3 72 |
| HCC38 | MK2206 | 3 | 72 | 1.0 | 2674.3 | 3214.0 | 1180.5 | 0.0 | 0.761 | 0.832 | 1.445 | HCC38 MK2206 0 3 72 |
| HCC38 | MK2206 | 3 | 72 | 0.32 | 2894.5 | 3214.0 | 1180.5 | -0.495 | 0.860 | 0.901 | 1.445 | HCC38 MK2206 0 3 72 |
| HCC38 | MK2206 | 3 | 72 | 0.1 | 3064.8 | 3214.0 | 1180.5 | -1.0 | 0.935 | 0.954 | 1.445 | HCC38 MK2206 0 3 72 |
| HCC38 | MK2206 | 3 | 72 | 0.032 | 3014.3 | 3214.0 | 1180.5 | -1.49 | 0.913 | 0.938 | 1.445 | HCC38 MK2206 0 3 72 |
| HCC38 | MK2206 | 3 | 72 | 0.01 | 3039.8 | 3214.0 | 1180.5 | -2.0 | 0.924 | 0.946 | 1.445 | HCC38 MK2206 0 3 72 |
| HCC38 | MK2206 | 3 | 72 | 0.0032 | 2977.0 | 3214.0 | 1180.5 | -2.49 | 0.897 | 0.926 | 1.445 | HCC38 MK2206 0 3 72 |
| HCC38 | MK2206 | 3 | 72 | 0.001 | 3128.3 | 3214.0 | 1180.5 | -3.0 | 0.963 | 0.973 | 1.445 | HCC38 MK2206 0 3 72 |
| HCC38 | KIN001-244 | 3 | 72 | 3.2 | 3010.0 | 3275.0 | 1180.5 | 0.505 | 0.889 | 0.919 | 1.472 | HCC38 KIN001-244 0 3 72 |
| HCC38 | KIN001-244 | 3 | 72 | 1.0 | 2916.5 | 3275.0 | 1180.5 | 0.0 | 0.849 | 0.891 | 1.472 | HCC38 KIN001-244 0 3 72 |
| HCC38 | KIN001-244 | 3 | 72 | 0.32 | 3183.5 | 3275.0 | 1180.5 | -0.495 | 0.962 | 0.972 | 1.472 | HCC38 KIN001-244 0 3 72 |
| HCC38 | KIN001-244 | 3 | 72 | 0.1 | 3200.8 | 3275.0 | 1180.5 | -1.0 | 0.969 | 0.977 | 1.472 | HCC38 KIN001-244 0 3 72 |
| HCC38 | KIN001-244 | 3 | 72 | 0.032 | 3072.5 | 3275.0 | 1180.5 | -1.49 | 0.915 | 0.938 | 1.472 | HCC38 KIN001-244 0 3 72 |
| HCC38 | KIN001-244 | 3 | 72 | 0.01 | 3082.0 | 3275.0 | 1180.5 | -2.0 | 0.919 | 0.941 | 1.472 | HCC38 KIN001-244 0 3 72 |