Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | AZD-6482 | 1 | 72 | 0.32 | 5060.8 | 5948.8 | 1443.3 | -0.495 | 0.848 | 0.851 | 2.043 | BT20 AZD6482 0 1 |
| BT-20 | PI103 | 1 | 72 | 0.0032 | 5811.0 | 5476.0 | 1443.3 | -2.49 | 1.060 | 1.060 | 1.924 | BT20 PI103 0 1 |
| BT-20 | CAL-101 | 1 | 72 | 0.001 | 5598.0 | 6240.0 | 1443.3 | -3.0 | 0.900 | 0.897 | 2.112 | BT20 CAL101 0 1 |
| BT-20 | PI103 | 1 | 72 | 0.01 | 6019.5 | 5476.0 | 1443.3 | -2.0 | 1.100 | 1.100 | 1.924 | BT20 PI103 0 1 |
| BT-549 | Dactolisib | 1 | 72 | 1.0 | 1630.8 | 5568.8 | 1554.9 | 0.0 | 0.026 | 0.293 | 1.840 | BT549 BEZ235 0 1 72 |
| BT-20 | PI103 | 1 | 72 | 0.032 | 6102.5 | 5476.0 | 1443.3 | -1.49 | 1.120 | 1.110 | 1.924 | BT20 PI103 0 1 |
| BT-20 | CAL-101 | 1 | 72 | 0.0032 | 5972.5 | 6240.0 | 1443.3 | -2.49 | 0.959 | 0.957 | 2.112 | BT20 CAL101 0 1 |
| BT-20 | PI103 | 1 | 72 | 0.1 | 5635.0 | 5476.0 | 1443.3 | -1.0 | 1.030 | 1.030 | 1.924 | BT20 PI103 0 1 |
| BT-549 | Buparlisib | 1 | 72 | 0.01 | 5470.3 | 5555.8 | 1554.9 | -2.0 | 0.983 | 0.985 | 1.837 | BT549 BKM120 0 1 72 |
| BT-20 | PI103 | 1 | 72 | 0.32 | 4753.0 | 5476.0 | 1443.3 | -0.495 | 0.858 | 0.868 | 1.924 | BT20 PI103 0 1 |
| BT-20 | CAL-101 | 1 | 72 | 0.01 | 5904.0 | 6240.0 | 1443.3 | -2.0 | 0.948 | 0.946 | 2.112 | BT20 CAL101 0 1 |
| BT-20 | PI103 | 1 | 72 | 1.0 | 2166.0 | 5476.0 | 1443.3 | 0.0 | 0.235 | 0.396 | 1.924 | BT20 PI103 0 1 |
| BT-549 | Buparlisib | 1 | 72 | 1.0 | 2671.5 | 5555.8 | 1554.9 | 0.0 | 0.343 | 0.481 | 1.837 | BT549 BKM120 0 1 72 |
| BT-20 | PI103 | 1 | 72 | 3.2 | 1411.8 | 5476.0 | 1443.3 | 0.505 | -0.011 | 0.258 | 1.924 | BT20 PI103 0 1 |
| BT-20 | CAL-101 | 1 | 72 | 0.032 | 6025.0 | 6240.0 | 1443.3 | -1.49 | 0.967 | 0.966 | 2.112 | BT20 CAL101 0 1 |
| BT-20 | PIK-93 | 1 | 72 | 0.001 | 5862.8 | 5875.8 | 1443.3 | -3.0 | 0.998 | 0.998 | 2.025 | BT20 PIK93 0 1 |
| BT-20 | AZD-6482 | 1 | 72 | 1.0 | 3655.0 | 5948.8 | 1443.3 | 0.0 | 0.576 | 0.614 | 2.043 | BT20 AZD6482 0 1 |
| BT-20 | PIK-93 | 1 | 72 | 0.0032 | 5799.0 | 5875.8 | 1443.3 | -2.49 | 0.987 | 0.987 | 2.025 | BT20 PIK93 0 1 |
| BT-20 | CAL-101 | 1 | 72 | 0.1 | 6019.8 | 6240.0 | 1443.3 | -1.0 | 0.966 | 0.965 | 2.112 | BT20 CAL101 0 1 |
| BT-20 | PIK-93 | 1 | 72 | 0.01 | 5717.0 | 5875.8 | 1443.3 | -2.0 | 0.973 | 0.973 | 2.025 | BT20 PIK93 0 1 |
| BT-549 | BX-912 | 1 | 72 | 1.0 | 3078.0 | 5561.8 | 1554.9 | 0.0 | 0.450 | 0.553 | 1.839 | BT549 BX912 0 1 72 |
| BT-20 | PIK-93 | 1 | 72 | 0.032 | 5933.3 | 5875.8 | 1443.3 | -1.49 | 1.010 | 1.010 | 2.025 | BT20 PIK93 0 1 |
| BT-20 | CAL-101 | 1 | 72 | 0.32 | 6047.5 | 6240.0 | 1443.3 | -0.495 | 0.971 | 0.969 | 2.112 | BT20 CAL101 0 1 |
| BT-549 | CAL-101 | 1 | 72 | 0.0032 | 5244.8 | 5381.3 | 1554.9 | -2.49 | 0.972 | 0.975 | 1.791 | BT549 CAL101 0 1 72 |
| BT-549 | CAL-101 | 1 | 72 | 0.001 | 5321.8 | 5381.3 | 1554.9 | -3.0 | 0.988 | 0.989 | 1.791 | BT549 CAL101 0 1 72 |