Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | ZSTK474 | 3 | 72 | 0.01 | 3124.3 | 2931.3 | 517.3 | -2.0 | 1.050 | 1.070 | 2.502 | HCC70 ZSTK474 0 3 72 |
| HCC70 | GDC-0980 | 2 | 72 | 0.0032 | 2472.8 | 2310.0 | 722.8 | -2.49 | 1.080 | 1.070 | 1.676 | HCC70 GDC0980 0 2 72 |
| HCC70 | GDC-0980 | 2 | 72 | 0.001 | 2471.0 | 2310.0 | 722.8 | -3.0 | 1.080 | 1.070 | 1.676 | HCC70 GDC0980 0 2 72 |
| HCC70 | MK2206 | 2 | 72 | 0.001 | 2488.5 | 2332.3 | 722.8 | -3.0 | 1.080 | 1.070 | 1.690 | HCC70 MK2206 0 2 72 |
| Hs 578T | BX-912 | 3 | 72 | 0.01 | 4285.5 | 3993.8 | 571.3 | -2.0 | 1.050 | 1.070 | 2.805 | Hs578T BX912 3 |
| Hs 578T | BX-912 | 3 | 72 | 0.032 | 4271.3 | 3993.8 | 571.3 | -1.49 | 1.050 | 1.070 | 2.805 | Hs578T BX912 3 |
| BT-549 | Alpelisib | 2 | 72 | 0.001 | 5072.5 | 4752.0 | 1249.6 | -3.0 | 1.070 | 1.070 | 1.927 | BT549 BYL719 0 2 72 |
| HCC70 | Buparlisib | 2 | 72 | 0.01 | 2554.8 | 2387.5 | 722.8 | -2.0 | 1.080 | 1.070 | 1.724 | HCC70 BKM120 0 2 72 |
| HCC70 | BX-912 | 3 | 72 | 0.032 | 3057.0 | 2856.5 | 517.3 | -1.49 | 1.060 | 1.070 | 2.465 | HCC70 BX912 0 3 72 |
| BT-20 | ZSTK474 | 1 | 72 | 0.0032 | 5912.0 | 5537.8 | 1443.3 | -2.49 | 1.070 | 1.070 | 1.940 | BT20 ZSTK474 0 1 |
| HCC70 | BX-912 | 3 | 72 | 0.0032 | 3057.0 | 2856.5 | 517.3 | -2.49 | 1.060 | 1.070 | 2.465 | HCC70 BX912 0 3 72 |
| HCC70 | XL147 | 3 | 72 | 1.0 | 3115.8 | 2882.5 | 517.3 | 0.0 | 1.060 | 1.080 | 2.478 | HCC70 XL147 0 3 72 |
| HCC70 | XL147 | 1 | 72 | 0.1 | 3620.5 | 3367.3 | 1279.8 | -1.0 | 1.110 | 1.080 | 1.396 | HCC70 XL147 0 1 72 |
| BT-20 | ZSTK474 | 1 | 72 | 0.001 | 5978.0 | 5537.8 | 1443.3 | -3.0 | 1.080 | 1.080 | 1.940 | BT20 ZSTK474 0 1 |
| HCC70 | PI103 | 3 | 72 | 0.01 | 3081.3 | 2818.5 | 517.3 | -2.0 | 1.070 | 1.090 | 2.446 | HCC70 PI103 0 3 72 |
| BT-20 | ZSTK474 | 1 | 72 | 0.1 | 6021.3 | 5537.8 | 1443.3 | -1.0 | 1.090 | 1.090 | 1.940 | BT20 ZSTK474 0 1 |
| HCC70 | MK2206 | 2 | 72 | 0.01 | 2536.8 | 2332.3 | 722.8 | -2.0 | 1.100 | 1.090 | 1.690 | HCC70 MK2206 0 2 72 |
| BT-20 | ZSTK474 | 1 | 72 | 0.01 | 6056.8 | 5537.8 | 1443.3 | -2.0 | 1.090 | 1.090 | 1.940 | BT20 ZSTK474 0 1 |
| HCC70 | Pictilisib | 3 | 72 | 0.0032 | 3088.5 | 2827.0 | 517.3 | -2.49 | 1.070 | 1.090 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | PIK-93 | 2 | 72 | 0.032 | 2573.3 | 2356.8 | 722.8 | -1.49 | 1.110 | 1.090 | 1.705 | HCC70 PIK93 0 2 72 |
| HCC70 | Buparlisib | 1 | 72 | 0.032 | 3663.5 | 3318.0 | 1279.8 | -1.49 | 1.150 | 1.100 | 1.374 | HCC70 BKM120 0 1 72 |
| HCC70 | ZSTK474 | 1 | 72 | 0.001 | 3541.3 | 3221.8 | 1279.8 | -3.0 | 1.150 | 1.100 | 1.332 | HCC70 ZSTK474 0 1 72 |
| BT-20 | PI103 | 1 | 72 | 0.01 | 6019.5 | 5476.0 | 1443.3 | -2.0 | 1.100 | 1.100 | 1.924 | BT20 PI103 0 1 |
| BT-20 | PI103 | 1 | 72 | 0.032 | 6102.5 | 5476.0 | 1443.3 | -1.49 | 1.120 | 1.110 | 1.924 | BT20 PI103 0 1 |
| HCC70 | PI103 | 1 | 72 | 0.032 | 3551.3 | 3161.3 | 1279.8 | -1.49 | 1.190 | 1.120 | 1.305 | HCC70 PI103 0 1 72 |