Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | Dactolisib | 3 | 72 | 1.0 | 1156.3 | 4098.5 | 1175.8 | 0.0 | -0.009 | 0.282 | 1.801 | BT549 BEZ235 0 3 72 |
| Hs 578T | Omipalisib | 2 | 72 | 0.1 | 1004.5 | 3550.3 | 624.7 | -1.0 | 0.209 | 0.283 | 2.507 | Hs578T GSK458 2 |
| BT-549 | Dactolisib | 3 | 72 | 3.2 | 1161.8 | 4098.5 | 1175.8 | 0.505 | -0.007 | 0.283 | 1.801 | BT549 BEZ235 0 3 72 |
| Hs 578T | Omipalisib | 3 | 72 | 0.1 | 1188.5 | 4175.0 | 571.3 | -1.0 | 0.291 | 0.285 | 2.869 | Hs578T GSK458 3 |
| Hs 578T | AZD8055 | 1 | 72 | 3.2 | 1005.8 | 3514.5 | 873.1 | 0.505 | 0.073 | 0.286 | 2.009 | Hs578T AZD8055 1 |
| Hs 578T | Dactolisib | 3 | 72 | 0.1 | 1169.3 | 4081.0 | 571.3 | -1.0 | 0.287 | 0.287 | 2.837 | Hs578T BEZ235 3 |
| BT-549 | Torin1 | 2 | 72 | 3.2 | 1320.5 | 4603.3 | 1249.6 | 0.505 | 0.030 | 0.287 | 1.881 | BT549 Torin1 0 2 72 |
| BT-549 | Omipalisib | 2 | 72 | 0.1 | 1429.3 | 4963.8 | 1249.6 | -1.0 | 0.070 | 0.288 | 1.990 | BT549 GSK458 0 2 72 |
| BT-20 | Torin1 | 3 | 72 | 0.1 | 1001.5 | 3483.3 | 586.9 | -1.0 | 0.231 | 0.288 | 2.569 | BT20 Torin1 0 3 |
| BT-549 | Torin2 | 1 | 72 | 0.32 | 1528.8 | 5306.0 | 1554.9 | -0.495 | -0.010 | 0.288 | 1.771 | BT549 Torin2 0 1 72 |
| BT-20 | Buparlisib | 2 | 72 | 1.0 | 986.5 | 3408.8 | 1018.6 | 0.0 | -0.018 | 0.289 | 1.743 | BT20 BKM120 0 2 |
| Hs 578T | WYE-125132 | 1 | 72 | 3.2 | 1021.0 | 3529.8 | 873.1 | 0.505 | 0.081 | 0.289 | 2.015 | Hs578T WYE125132 1 |
| HCC38 | Omipalisib | 3 | 72 | 0.32 | 933.8 | 3215.3 | 1180.5 | -0.495 | -0.150 | 0.290 | 1.446 | HCC38 GSK458 0 3 72 |
| Hs 578T | Dactolisib | 3 | 72 | 0.032 | 1181.8 | 4081.0 | 571.3 | -1.49 | 0.292 | 0.290 | 2.837 | Hs578T BEZ235 3 |
| HCC38 | Dactolisib | 3 | 72 | 1.0 | 951.0 | 3265.3 | 1180.5 | 0.0 | -0.137 | 0.291 | 1.468 | HCC38 BEZ235 0 3 72 |
| HCC70 | Torin2 | 1 | 72 | 0.32 | 957.5 | 3294.3 | 1279.8 | -0.495 | -0.192 | 0.291 | 1.364 | HCC70 Torin2 0 1 72 |
| BT-20 | Torin1 | 1 | 72 | 1.0 | 1708.3 | 5863.3 | 1443.3 | 0.0 | 0.087 | 0.291 | 2.022 | BT20 Torin1 0 1 |
| BT-549 | Dactolisib | 1 | 72 | 1.0 | 1630.8 | 5568.8 | 1554.9 | 0.0 | 0.026 | 0.293 | 1.840 | BT549 BEZ235 0 1 72 |
| HCC1806 | Omipalisib | 2 | 72 | 0.32 | 3470.8 | 11840.0 | 1643.3 | -0.495 | 0.300 | 0.293 | 2.849 | HCC1806 GSK458 0 2 72 |
| HCC1806 | Omipalisib | 3 | 72 | 0.32 | 3470.8 | 11840.0 | 1273.3 | -0.495 | 0.366 | 0.293 | 3.217 | HCC1806 GSK458 0 3 72 |
| HCC70 | GDC-0980 | 3 | 72 | 3.2 | 814.0 | 2773.8 | 517.3 | 0.505 | 0.206 | 0.293 | 2.423 | HCC70 GDC0980 0 3 72 |
| HCC1806 | Omipalisib | 1 | 72 | 0.32 | 3470.8 | 11840.0 | 1742.8 | -0.495 | 0.283 | 0.293 | 2.764 | HCC1806 GSK458 0 1 72 |
| BT-549 | Dactolisib | 2 | 72 | 1.0 | 1361.5 | 4628.8 | 1249.6 | 0.0 | 0.047 | 0.294 | 1.889 | BT549 BEZ235 0 2 72 |
| HCC38 | Torin1 | 2 | 72 | 1.0 | 895.5 | 3034.5 | 690.5 | 0.0 | 0.129 | 0.295 | 2.136 | HCC38 Torin1 0 2 72 |
| HCC70 | Omipalisib | 1 | 72 | 0.032 | 968.5 | 3280.0 | 1279.8 | -1.49 | -0.186 | 0.295 | 1.358 | HCC70 GSK458 0 1 72 |