Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Trametinib | 3 | 72 | 0.0032 | 2978.0 | 3410.0 | 586.9 | -2.49 | 0.896 | 0.873 | 2.539 | BT20 Trametinib 0 3 |
| BT-20 | Trametinib | 3 | 72 | 0.001 | 3203.3 | 3410.0 | 586.9 | -3.0 | 0.951 | 0.939 | 2.539 | BT20 Trametinib 0 3 |
| BT-20 | Trametinib | 3 | 72 | 0.032 | 2817.0 | 3410.0 | 586.9 | -1.49 | 0.855 | 0.826 | 2.539 | BT20 Trametinib 0 3 |
| BT-20 | Trametinib | 3 | 72 | 0.01 | 2753.3 | 3410.0 | 586.9 | -2.0 | 0.838 | 0.807 | 2.539 | BT20 Trametinib 0 3 |
| BT-20 | WYE-125132 | 1 | 72 | 0.001 | 5623.5 | 5739.3 | 1443.3 | -3.0 | 0.980 | 0.980 | 1.991 | BT20 WYE125132 0 1 |
| BT-20 | WYE-125132 | 1 | 72 | 0.0032 | 5504.3 | 5739.3 | 1443.3 | -2.49 | 0.958 | 0.959 | 1.991 | BT20 WYE125132 0 1 |
| BT-20 | WYE-125132 | 1 | 72 | 3.2 | 2287.3 | 5739.3 | 1443.3 | 0.505 | 0.260 | 0.399 | 1.991 | BT20 WYE125132 0 1 |
| BT-20 | WYE-125132 | 1 | 72 | 0.01 | 5356.0 | 5739.3 | 1443.3 | -2.0 | 0.932 | 0.933 | 1.991 | BT20 WYE125132 0 1 |
| BT-20 | WYE-125132 | 1 | 72 | 1.0 | 2450.3 | 5739.3 | 1443.3 | 0.0 | 0.304 | 0.427 | 1.991 | BT20 WYE125132 0 1 |
| BT-20 | WYE-125132 | 1 | 72 | 0.32 | 2481.3 | 5739.3 | 1443.3 | -0.495 | 0.313 | 0.432 | 1.991 | BT20 WYE125132 0 1 |
| BT-20 | WYE-125132 | 1 | 72 | 0.1 | 3326.8 | 5739.3 | 1443.3 | -1.0 | 0.521 | 0.580 | 1.991 | BT20 WYE125132 0 1 |
| BT-20 | WYE-125132 | 1 | 72 | 0.032 | 4261.5 | 5739.3 | 1443.3 | -1.49 | 0.722 | 0.743 | 1.991 | BT20 WYE125132 0 1 |
| BT-20 | WYE-125132 | 2 | 72 | 3.2 | 831.0 | 3613.5 | 1018.6 | 0.505 | -0.105 | 0.230 | 1.827 | BT20 WYE125132 0 2 |
| BT-20 | WYE-125132 | 2 | 72 | 1.0 | 847.0 | 3613.5 | 1018.6 | 0.0 | -0.096 | 0.234 | 1.827 | BT20 WYE125132 0 2 |
| BT-20 | WYE-125132 | 2 | 72 | 0.32 | 887.5 | 3613.5 | 1018.6 | -0.495 | -0.073 | 0.246 | 1.827 | BT20 WYE125132 0 2 |
| BT-20 | WYE-125132 | 2 | 72 | 0.1 | 1155.5 | 3613.5 | 1018.6 | -1.0 | 0.072 | 0.320 | 1.827 | BT20 WYE125132 0 2 |
| BT-20 | WYE-125132 | 2 | 72 | 0.032 | 1915.3 | 3613.5 | 1018.6 | -1.49 | 0.413 | 0.530 | 1.827 | BT20 WYE125132 0 2 |
| BT-20 | WYE-125132 | 2 | 72 | 0.01 | 2746.5 | 3613.5 | 1018.6 | -2.0 | 0.721 | 0.760 | 1.827 | BT20 WYE125132 0 2 |
| BT-20 | WYE-125132 | 2 | 72 | 0.0032 | 3226.8 | 3613.5 | 1018.6 | -2.49 | 0.880 | 0.893 | 1.827 | BT20 WYE125132 0 2 |
| BT-20 | WYE-125132 | 2 | 72 | 0.001 | 2942.5 | 3613.5 | 1018.6 | -3.0 | 0.787 | 0.814 | 1.827 | BT20 WYE125132 0 2 |
| BT-20 | WYE-125132 | 3 | 72 | 0.1 | 1137.8 | 3344.0 | 586.9 | -1.0 | 0.302 | 0.340 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | WYE-125132 | 3 | 72 | 0.032 | 2304.3 | 3344.0 | 586.9 | -1.49 | 0.724 | 0.689 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | WYE-125132 | 3 | 72 | 0.01 | 2864.0 | 3344.0 | 586.9 | -2.0 | 0.880 | 0.856 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | WYE-125132 | 3 | 72 | 0.0032 | 2937.3 | 3344.0 | 586.9 | -2.49 | 0.899 | 0.878 | 2.510 | BT20 WYE125132 0 3 |
| BT-20 | WYE-125132 | 3 | 72 | 0.001 | 3058.5 | 3344.0 | 586.9 | -3.0 | 0.930 | 0.915 | 2.510 | BT20 WYE125132 0 3 |