Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Omipalisib | 2 | 72 | 0.1 | 664.8 | 3349.0 | 1018.6 | -1.0 | -0.220 | 0.199 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Omipalisib | 2 | 72 | 0.032 | 647.3 | 3349.0 | 1018.6 | -1.49 | -0.232 | 0.193 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Omipalisib | 2 | 72 | 0.01 | 1065.3 | 3349.0 | 1018.6 | -2.0 | 0.026 | 0.318 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Omipalisib | 2 | 72 | 0.0032 | 2069.3 | 3349.0 | 1018.6 | -2.49 | 0.511 | 0.618 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Omipalisib | 2 | 72 | 0.001 | 3128.0 | 3349.0 | 1018.6 | -3.0 | 0.922 | 0.934 | 1.717 | BT20 GSK458 0 2 |
| BT-20 | Omipalisib | 3 | 72 | 0.01 | 1223.5 | 3523.0 | 586.9 | -2.0 | 0.329 | 0.347 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | Omipalisib | 3 | 72 | 0.0032 | 2230.0 | 3523.0 | 586.9 | -2.49 | 0.676 | 0.633 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | Omipalisib | 3 | 72 | 0.001 | 2990.5 | 3523.0 | 586.9 | -3.0 | 0.877 | 0.849 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | Omipalisib | 3 | 72 | 1.0 | 151.5 | 3523.0 | 586.9 | 0.0 | -0.408 | 0.043 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | Omipalisib | 3 | 72 | 0.032 | 723.0 | 3523.0 | 586.9 | -1.49 | 0.084 | 0.205 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | Omipalisib | 3 | 72 | 0.1 | 595.3 | 3523.0 | 586.9 | -1.0 | 0.005 | 0.169 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | Omipalisib | 3 | 72 | 0.32 | 473.0 | 3523.0 | 586.9 | -0.495 | -0.080 | 0.134 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | Omipalisib | 3 | 72 | 3.2 | 59.8 | 3523.0 | 586.9 | 0.505 | -0.587 | 0.017 | 2.586 | BT20 GSK458 0 3 |
| BT-20 | KIN001-244 | 1 | 72 | 0.001 | 6021.5 | 6295.0 | 1443.3 | -3.0 | 0.959 | 0.957 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | KIN001-244 | 1 | 72 | 3.2 | 5716.5 | 6295.0 | 1443.3 | 0.505 | 0.911 | 0.908 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | KIN001-244 | 1 | 72 | 0.01 | 6085.0 | 6295.0 | 1443.3 | -2.0 | 0.968 | 0.967 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | KIN001-244 | 1 | 72 | 0.0032 | 5775.0 | 6295.0 | 1443.3 | -2.49 | 0.920 | 0.917 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | KIN001-244 | 1 | 72 | 1.0 | 5975.3 | 6295.0 | 1443.3 | 0.0 | 0.952 | 0.949 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | KIN001-244 | 1 | 72 | 0.32 | 6065.5 | 6295.0 | 1443.3 | -0.495 | 0.965 | 0.964 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | KIN001-244 | 1 | 72 | 0.1 | 6567.5 | 6295.0 | 1443.3 | -1.0 | 1.040 | 1.040 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | KIN001-244 | 1 | 72 | 0.032 | 5891.5 | 6295.0 | 1443.3 | -1.49 | 0.939 | 0.936 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | KIN001-244 | 2 | 72 | 3.2 | 2975.3 | 3407.5 | 1018.6 | 0.505 | 0.850 | 0.873 | 1.742 | BT20 KIN001-244 0 2 |
| BT-20 | KIN001-244 | 2 | 72 | 1.0 | 3085.0 | 3407.5 | 1018.6 | 0.0 | 0.889 | 0.905 | 1.742 | BT20 KIN001-244 0 2 |
| BT-20 | KIN001-244 | 2 | 72 | 0.32 | 3166.5 | 3407.5 | 1018.6 | -0.495 | 0.918 | 0.929 | 1.742 | BT20 KIN001-244 0 2 |
| BT-20 | KIN001-244 | 2 | 72 | 0.1 | 3321.3 | 3407.5 | 1018.6 | -1.0 | 0.971 | 0.975 | 1.742 | BT20 KIN001-244 0 2 |