Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)

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Cell line Drug name Experimental replicate Timepoint Drug concentration Live cell count Average live cell count, DMSO control Average live cell count (time = 0) Log10(drug concentration) GR value Relative cell count (treatment versus DMSO) Cell doublings (DMSO control) Experiment name
HCC70 MK2206 2 72
0.032
 2371.0 2332.3 722.8
-1.49
 1.020 1.020 1.690
HCC70 MK2206 0 2 72
HCC70 MK2206 2 72
0.01
 2536.8 2332.3 722.8
-2.0
 1.100 1.090 1.690
HCC70 MK2206 0 2 72
HCC70 MK2206 2 72
0.0032
 2410.8 2332.3 722.8
-2.49
 1.040 1.030 1.690
HCC70 MK2206 0 2 72
HCC70 MK2206 2 72
0.001
 2488.5 2332.3 722.8
-3.0
 1.080 1.070 1.690
HCC70 MK2206 0 2 72
BT-20 Alpelisib 2 72
3.2
 853.3 3290.8 1018.6
0.505
 -0.099 0.259 1.692
BT20 BYL719 0 2
BT-20 Alpelisib 2 72
1.0
 1205.3 3290.8 1018.6
0.0
 0.105 0.366 1.692
BT20 BYL719 0 2
BT-20 Alpelisib 2 72
0.32
 2133.8 3290.8 1018.6
-0.495
 0.548 0.648 1.692
BT20 BYL719 0 2
BT-20 Alpelisib 2 72
0.1
 2742.0 3290.8 1018.6
-1.0
 0.796 0.833 1.692
BT20 BYL719 0 2
BT-20 Alpelisib 2 72
0.032
 2570.0 3290.8 1018.6
-1.49
 0.728 0.781 1.692
BT20 BYL719 0 2
BT-20 Alpelisib 2 72
0.01
 3212.8 3290.8 1018.6
-2.0
 0.972 0.976 1.692
BT20 BYL719 0 2
BT-20 Alpelisib 2 72
0.0032
 2510.5 3290.8 1018.6
-2.49
 0.704 0.763 1.692
BT20 BYL719 0 2
BT-20 Alpelisib 2 72
0.001
 2564.0 3290.8 1018.6
-3.0
 0.726 0.779 1.692
BT20 BYL719 0 2
HCC70 BX-912 2 72
3.2
 726.0 2337.5 722.8
0.505
 0.003 0.311 1.693
HCC70 BX912 0 2 72
HCC70 BX-912 2 72
1.0
 1866.5 2337.5 722.8
0.0
 0.751 0.799 1.693
HCC70 BX912 0 2 72
HCC70 BX-912 2 72
0.32
 2383.0 2337.5 722.8
-0.495
 1.020 1.020 1.693
HCC70 BX912 0 2 72
HCC70 BX-912 2 72
0.032
 2615.0 2337.5 722.8
-1.49
 1.140 1.120 1.693
HCC70 BX912 0 2 72
HCC70 BX-912 2 72
0.1
 2469.0 2337.5 722.8
-1.0
 1.070 1.060 1.693
HCC70 BX912 0 2 72
HCC70 BX-912 2 72
0.01
 2386.3 2337.5 722.8
-2.0
 1.020 1.020 1.693
HCC70 BX912 0 2 72
HCC70 BX-912 2 72
0.0032
 2419.0 2337.5 722.8
-2.49
 1.040 1.030 1.693
HCC70 BX912 0 2 72
HCC70 BX-912 2 72
0.001
 2448.0 2337.5 722.8
-3.0
 1.060 1.050 1.693
HCC70 BX912 0 2 72
BT-20 BX-912 2 72
3.2
 1884.8 3312.0 1018.6
0.505
 0.436 0.569 1.701
BT20 BX912 0 2
BT-20 BX-912 2 72
1.0
 2918.0 3312.0 1018.6
0.0
 0.857 0.881 1.701
BT20 BX912 0 2
BT-20 BX-912 2 72
0.32
 3032.5 3312.0 1018.6
-0.495
 0.899 0.916 1.701
BT20 BX912 0 2
BT-20 BX-912 2 72
0.1
 3064.0 3312.0 1018.6
-1.0
 0.911 0.925 1.701
BT20 BX912 0 2
BT-20 BX-912 2 72
0.032
 3160.3 3312.0 1018.6
-1.49
 0.946 0.954 1.701
BT20 BX912 0 2