Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | MK2206 | 3 | 72 | 3.2 | 3111.8 | 4213.3 | 571.3 | 0.505 | 0.800 | 0.739 | 2.883 | Hs578T MK2206 3 |
| Hs 578T | MK2206 | 3 | 72 | 1.0 | 2805.5 | 4213.3 | 571.3 | 0.0 | 0.737 | 0.666 | 2.883 | Hs578T MK2206 3 |
| Hs 578T | MK2206 | 3 | 72 | 0.32 | 3171.5 | 4213.3 | 571.3 | -0.495 | 0.812 | 0.753 | 2.883 | Hs578T MK2206 3 |
| Hs 578T | MK2206 | 3 | 72 | 0.1 | 3787.8 | 4213.3 | 571.3 | -1.0 | 0.927 | 0.899 | 2.883 | Hs578T MK2206 3 |
| Hs 578T | MK2206 | 3 | 72 | 0.032 | 4056.0 | 4213.3 | 571.3 | -1.49 | 0.974 | 0.963 | 2.883 | Hs578T MK2206 3 |
| Hs 578T | MK2206 | 3 | 72 | 0.01 | 4132.8 | 4213.3 | 571.3 | -2.0 | 0.987 | 0.981 | 2.883 | Hs578T MK2206 3 |
| Hs 578T | MK2206 | 3 | 72 | 0.001 | 4169.3 | 4213.3 | 571.3 | -3.0 | 0.993 | 0.990 | 2.883 | Hs578T MK2206 3 |
| Hs 578T | AZD8055 | 3 | 72 | 0.1 | 1460.5 | 4224.8 | 571.3 | -1.0 | 0.384 | 0.346 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | AZD8055 | 3 | 72 | 1.0 | 1042.3 | 4224.8 | 571.3 | 0.0 | 0.232 | 0.247 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | AZD8055 | 3 | 72 | 3.2 | 1096.0 | 4224.8 | 571.3 | 0.505 | 0.253 | 0.259 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | AZD8055 | 3 | 72 | 0.001 | 3907.0 | 4224.8 | 571.3 | -3.0 | 0.947 | 0.925 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | AZD8055 | 3 | 72 | 0.0032 | 3743.8 | 4224.8 | 571.3 | -2.49 | 0.918 | 0.886 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | AZD8055 | 3 | 72 | 0.01 | 3228.5 | 4224.8 | 571.3 | -2.0 | 0.822 | 0.764 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | AZD8055 | 3 | 72 | 0.032 | 2320.3 | 4224.8 | 571.3 | -1.49 | 0.625 | 0.549 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | AZD8055 | 3 | 72 | 0.32 | 1113.3 | 4224.8 | 571.3 | -0.495 | 0.260 | 0.264 | 2.886 | Hs578T AZD8055 3 |
| Hs 578T | KIN001-244 | 3 | 72 | 3.2 | 3459.8 | 4230.0 | 571.3 | 0.505 | 0.866 | 0.818 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | KIN001-244 | 3 | 72 | 1.0 | 4018.5 | 4230.0 | 571.3 | 0.0 | 0.965 | 0.950 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | KIN001-244 | 3 | 72 | 0.32 | 4089.3 | 4230.0 | 571.3 | -0.495 | 0.977 | 0.967 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | KIN001-244 | 3 | 72 | 0.001 | 4053.8 | 4230.0 | 571.3 | -3.0 | 0.971 | 0.958 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | KIN001-244 | 3 | 72 | 0.0032 | 4381.5 | 4230.0 | 571.3 | -2.49 | 1.020 | 1.040 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | KIN001-244 | 3 | 72 | 0.01 | 4310.0 | 4230.0 | 571.3 | -2.0 | 1.010 | 1.020 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | KIN001-244 | 3 | 72 | 0.032 | 4396.5 | 4230.0 | 571.3 | -1.49 | 1.030 | 1.040 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | KIN001-244 | 3 | 72 | 0.1 | 4310.0 | 4230.0 | 571.3 | -1.0 | 1.010 | 1.020 | 2.888 | Hs578T KIN001-244 3 |
| Hs 578T | Buparlisib | 3 | 72 | 0.1 | 3869.5 | 4235.0 | 571.3 | -1.0 | 0.939 | 0.914 | 2.890 | Hs578T BKM120 3 |
| Hs 578T | Buparlisib | 3 | 72 | 0.001 | 4118.3 | 4235.0 | 571.3 | -3.0 | 0.981 | 0.972 | 2.890 | Hs578T BKM120 3 |