Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | WYE-125132 | 3 | 72 | 3.2 | 940.0 | 4195.3 | 571.3 | 0.505 | 0.189 | 0.224 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.001 | 3852.0 | 4195.3 | 571.3 | -3.0 | 0.942 | 0.918 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.0032 | 3689.8 | 4195.3 | 571.3 | -2.49 | 0.913 | 0.880 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.01 | 3335.5 | 4195.3 | 571.3 | -2.0 | 0.847 | 0.795 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.032 | 2208.3 | 4195.3 | 571.3 | -1.49 | 0.600 | 0.526 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.1 | 1489.8 | 4195.3 | 571.3 | -1.0 | 0.395 | 0.355 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 0.32 | 1162.5 | 4195.3 | 571.3 | -0.495 | 0.280 | 0.277 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | WYE-125132 | 3 | 72 | 1.0 | 1048.5 | 4195.3 | 571.3 | 0.0 | 0.235 | 0.250 | 2.876 | Hs578T WYE125132 3 |
| Hs 578T | XL147 | 3 | 72 | 0.01 | 4398.8 | 4203.0 | 571.3 | -2.0 | 1.030 | 1.050 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 0.0032 | 4271.5 | 4203.0 | 571.3 | -2.49 | 1.010 | 1.020 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 3.2 | 4031.5 | 4203.0 | 571.3 | 0.505 | 0.971 | 0.959 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 1.0 | 4068.5 | 4203.0 | 571.3 | 0.0 | 0.978 | 0.968 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 0.32 | 4162.5 | 4203.0 | 571.3 | -0.495 | 0.993 | 0.990 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 0.1 | 4330.0 | 4203.0 | 571.3 | -1.0 | 1.020 | 1.030 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 0.032 | 4383.0 | 4203.0 | 571.3 | -1.49 | 1.030 | 1.040 | 2.879 | Hs578T XL147 3 |
| Hs 578T | XL147 | 3 | 72 | 0.001 | 4128.5 | 4203.0 | 571.3 | -3.0 | 0.988 | 0.982 | 2.879 | Hs578T XL147 3 |
| HCC1806 | Sirolimus | 2 | 72 | 0.0032 | 9333.0 | 12104.5 | 1643.3 | -2.49 | 0.827 | 0.771 | 2.881 | HCC1806 Rapamycin 0 2 72 |
| HCC1806 | Sirolimus | 2 | 72 | 0.01 | 9275.5 | 12104.5 | 1643.3 | -2.0 | 0.823 | 0.766 | 2.881 | HCC1806 Rapamycin 0 2 72 |
| HCC1806 | Sirolimus | 2 | 72 | 0.032 | 9181.8 | 12104.5 | 1643.3 | -1.49 | 0.817 | 0.759 | 2.881 | HCC1806 Rapamycin 0 2 72 |
| HCC1806 | Sirolimus | 2 | 72 | 0.1 | 9292.5 | 12104.5 | 1643.3 | -1.0 | 0.825 | 0.768 | 2.881 | HCC1806 Rapamycin 0 2 72 |
| HCC1806 | Sirolimus | 2 | 72 | 0.32 | 8965.0 | 12104.5 | 1643.3 | -0.495 | 0.802 | 0.741 | 2.881 | HCC1806 Rapamycin 0 2 72 |
| HCC1806 | Sirolimus | 2 | 72 | 1.0 | 9238.3 | 12104.5 | 1643.3 | 0.0 | 0.821 | 0.763 | 2.881 | HCC1806 Rapamycin 0 2 72 |
| HCC1806 | Sirolimus | 2 | 72 | 3.2 | 8674.0 | 12104.5 | 1643.3 | 0.505 | 0.782 | 0.717 | 2.881 | HCC1806 Rapamycin 0 2 72 |
| HCC1806 | Sirolimus | 2 | 72 | 0.001 | 9616.0 | 12104.5 | 1643.3 | -3.0 | 0.846 | 0.794 | 2.881 | HCC1806 Rapamycin 0 2 72 |
| Hs 578T | MK2206 | 3 | 72 | 0.0032 | 4157.8 | 4213.3 | 571.3 | -2.49 | 0.991 | 0.987 | 2.883 | Hs578T MK2206 3 |