Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | WYE-125132 | 1 | 72 | 0.001 | 5623.5 | 5739.3 | 1443.3 | -3.0 | 0.980 | 0.980 | 1.991 | BT20 WYE125132 0 1 |
| BT-20 | Omipalisib | 1 | 72 | 0.001 | 5515.0 | 6095.3 | 1443.3 | -3.0 | 0.906 | 0.905 | 2.078 | BT20 GSK458 0 1 |
| BT-20 | PIK-93 | 1 | 72 | 0.001 | 5862.8 | 5875.8 | 1443.3 | -3.0 | 0.998 | 0.998 | 2.025 | BT20 PIK93 0 1 |
| BT-20 | Trametinib | 2 | 72 | 0.001 | 2987.3 | 3363.5 | 1018.6 | -3.0 | 0.867 | 0.888 | 1.723 | BT20 Trametinib 0 2 |
| BT-20 | Pictilisib | 1 | 72 | 0.001 | 5849.5 | 6125.0 | 1443.3 | -3.0 | 0.956 | 0.955 | 2.085 | BT20 GDC0941 0 1 |
| BT-20 | AS605240 | 1 | 72 | 0.001 | 5834.8 | 6371.0 | 1443.3 | -3.0 | 0.920 | 0.916 | 2.142 | BT20 AS605240 0 1 |
| BT-20 | Buparlisib | 1 | 72 | 0.001 | 5907.8 | 6321.8 | 1443.3 | -3.0 | 0.937 | 0.935 | 2.131 | BT20 BKM120 0 1 |
| BT-20 | AZD8055 | 1 | 72 | 0.001 | 5501.0 | 5941.5 | 1443.3 | -3.0 | 0.926 | 0.926 | 2.041 | BT20 AZD8055 0 1 |
| BT-20 | Sirolimus | 1 | 72 | 0.001 | 3625.0 | 5856.5 | 1443.3 | -3.0 | 0.577 | 0.619 | 2.021 | BT20 Rapamycin 0 1 |
| BT-20 | AZD-6482 | 1 | 72 | 0.001 | 5532.3 | 5948.8 | 1443.3 | -3.0 | 0.930 | 0.930 | 2.043 | BT20 AZD6482 0 1 |
| BT-20 | KIN001-244 | 1 | 72 | 0.001 | 6021.5 | 6295.0 | 1443.3 | -3.0 | 0.959 | 0.957 | 2.125 | BT20 KIN001-244 0 1 |
| BT-20 | AZD-6482 | 2 | 72 | 0.001 | 2737.3 | 3186.5 | 1018.6 | -3.0 | 0.824 | 0.859 | 1.645 | BT20 AZD6482 0 2 |
| BT-20 | CAL-101 | 1 | 72 | 0.001 | 5598.0 | 6240.0 | 1443.3 | -3.0 | 0.900 | 0.897 | 2.112 | BT20 CAL101 0 1 |
| BT-20 | GDC-0980 | 1 | 72 | 0.001 | 5617.0 | 5778.5 | 1443.3 | -3.0 | 0.972 | 0.972 | 2.001 | BT20 GDC0980 0 1 |
| BT-20 | BX-912 | 1 | 72 | 0.001 | 5809.5 | 6155.0 | 1443.3 | -3.0 | 0.946 | 0.944 | 2.092 | BT20 BX912 0 1 |
| BT-20 | BX-912 | 2 | 72 | 0.001 | 2843.0 | 3312.0 | 1018.6 | -3.0 | 0.828 | 0.858 | 1.701 | BT20 BX912 0 2 |
| BT-20 | PI103 | 1 | 72 | 0.001 | 5370.5 | 5476.0 | 1443.3 | -3.0 | 0.980 | 0.981 | 1.924 | BT20 PI103 0 1 |
| BT-20 | Torin2 | 1 | 72 | 0.001 | 5188.5 | 5846.0 | 1443.3 | -3.0 | 0.885 | 0.888 | 2.018 | BT20 Torin2 0 1 |
| BT-20 | Everolimus | 2 | 72 | 0.001 | 1803.0 | 3213.5 | 1018.6 | -3.0 | 0.411 | 0.561 | 1.658 | BT20 Everolimus 0 2 |
| BT-20 | Torin1 | 1 | 72 | 0.001 | 5232.8 | 5863.3 | 1443.3 | -3.0 | 0.891 | 0.892 | 2.022 | BT20 Torin1 0 1 |
| BT-20 | GDC-0980 | 2 | 72 | 0.001 | 3333.5 | 3217.8 | 1018.6 | -3.0 | 1.040 | 1.040 | 1.659 | BT20 GDC0980 0 2 |
| BT-20 | Everolimus | 1 | 72 | 0.001 | 3773.0 | 5781.0 | 1443.3 | -3.0 | 0.616 | 0.653 | 2.002 | BT20 Everolimus 0 1 |
| BT-20 | Alpelisib | 1 | 72 | 0.001 | 5809.8 | 6091.5 | 1443.3 | -3.0 | 0.955 | 0.954 | 2.077 | BT20 BYL719 0 1 |
| BT-20 | AZD-6482 | 3 | 72 | 0.001 | 3256.8 | 3560.8 | 586.9 | -3.0 | 0.933 | 0.915 | 2.601 | BT20 AZD6482 0 3 |
| BT-20 | AS605240 | 3 | 72 | 0.001 | 3319.5 | 3575.0 | 586.9 | -3.0 | 0.944 | 0.929 | 2.607 | BT20 AS605240 0 3 |