Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | Alpelisib | 3 | 72 | 0.0032 | 2887.5 | 2855.8 | 517.3 | -2.49 | 1.010 | 1.010 | 2.465 | HCC70 BYL719 0 3 72 |
| HCC70 | Alpelisib | 3 | 72 | 0.01 | 2855.3 | 2855.8 | 517.3 | -2.0 | 1.000 | 1.000 | 2.465 | HCC70 BYL719 0 3 72 |
| HCC70 | Alpelisib | 3 | 72 | 0.1 | 2886.0 | 2855.8 | 517.3 | -1.0 | 1.010 | 1.010 | 2.465 | HCC70 BYL719 0 3 72 |
| HCC70 | Alpelisib | 3 | 72 | 0.32 | 2810.5 | 2855.8 | 517.3 | -0.495 | 0.987 | 0.984 | 2.465 | HCC70 BYL719 0 3 72 |
| HCC70 | CAL-101 | 3 | 72 | 0.0032 | 3109.5 | 2946.5 | 517.3 | -2.49 | 1.040 | 1.060 | 2.510 | HCC70 CAL101 0 3 72 |
| HCC70 | CAL-101 | 3 | 72 | 0.01 | 3008.5 | 2946.5 | 517.3 | -2.0 | 1.020 | 1.020 | 2.510 | HCC70 CAL101 0 3 72 |
| HCC70 | CAL-101 | 3 | 72 | 0.1 | 2909.3 | 2946.5 | 517.3 | -1.0 | 0.990 | 0.987 | 2.510 | HCC70 CAL101 0 3 72 |
| HCC70 | CAL-101 | 3 | 72 | 0.32 | 2922.3 | 2946.5 | 517.3 | -0.495 | 0.993 | 0.992 | 2.510 | HCC70 CAL101 0 3 72 |
| HCC70 | Everolimus | 3 | 72 | 0.001 | 2230.0 | 2731.3 | 517.3 | -3.0 | 0.838 | 0.816 | 2.401 | HCC70 Everolimus 0 3 72 |
| HCC70 | Everolimus | 3 | 72 | 0.0032 | 2166.5 | 2731.3 | 517.3 | -2.49 | 0.816 | 0.793 | 2.401 | HCC70 Everolimus 0 3 72 |
| HCC70 | Everolimus | 3 | 72 | 0.032 | 2167.0 | 2731.3 | 517.3 | -1.49 | 0.816 | 0.793 | 2.401 | HCC70 Everolimus 0 3 72 |
| HCC70 | Everolimus | 3 | 72 | 0.1 | 2178.5 | 2731.3 | 517.3 | -1.0 | 0.820 | 0.798 | 2.401 | HCC70 Everolimus 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 0.001 | 2799.3 | 2821.5 | 517.3 | -3.0 | 0.994 | 0.992 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 0.0032 | 2836.0 | 2821.5 | 517.3 | -2.49 | 1.000 | 1.010 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 0.032 | 2913.0 | 2821.5 | 517.3 | -1.49 | 1.030 | 1.030 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 0.1 | 2523.0 | 2821.5 | 517.3 | -1.0 | 0.911 | 0.894 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 3.2 | 1585.8 | 2821.5 | 517.3 | 0.505 | 0.580 | 0.562 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AZD-6482 | 3 | 72 | 0.001 | 2842.0 | 2991.0 | 517.3 | -3.0 | 0.960 | 0.950 | 2.532 | HCC70 AZD6482 0 3 72 |
| HCC70 | AZD-6482 | 3 | 72 | 0.01 | 2686.0 | 2991.0 | 517.3 | -2.0 | 0.917 | 0.898 | 2.532 | HCC70 AZD6482 0 3 72 |
| HCC70 | AZD-6482 | 3 | 72 | 0.032 | 2461.0 | 2991.0 | 517.3 | -1.49 | 0.852 | 0.823 | 2.532 | HCC70 AZD6482 0 3 72 |
| HCC70 | AZD-6482 | 3 | 72 | 3.2 | 1289.8 | 2991.0 | 517.3 | 0.505 | 0.435 | 0.431 | 2.532 | HCC70 AZD6482 0 3 72 |
| HCC70 | AZD8055 | 3 | 72 | 0.001 | 2586.0 | 2811.8 | 517.3 | -3.0 | 0.933 | 0.920 | 2.442 | HCC70 AZD8055 0 3 72 |
| HCC70 | AZD8055 | 3 | 72 | 0.01 | 2231.8 | 2811.8 | 517.3 | -2.0 | 0.819 | 0.794 | 2.442 | HCC70 AZD8055 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 0.01 | 2986.0 | 2827.0 | 517.3 | -2.0 | 1.050 | 1.060 | 2.450 | HCC70 GDC0941 0 3 72 |
| HCC70 | Pictilisib | 3 | 72 | 0.0032 | 3088.5 | 2827.0 | 517.3 | -2.49 | 1.070 | 1.090 | 2.450 | HCC70 GDC0941 0 3 72 |