Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | AZD-6482 | 3 | 72 | 0.001 | 3256.8 | 3560.8 | 586.9 | -3.0 | 0.933 | 0.915 | 2.601 | BT20 AZD6482 0 3 |
| BT-20 | PI103 | 3 | 72 | 1.0 | 851.5 | 3311.5 | 586.9 | 0.0 | 0.161 | 0.257 | 2.496 | BT20 PI103 0 3 |
| BT-20 | AS605240 | 3 | 72 | 3.2 | 2896.3 | 3575.0 | 586.9 | 0.505 | 0.845 | 0.810 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AS605240 | 3 | 72 | 1.0 | 2935.8 | 3575.0 | 586.9 | 0.0 | 0.854 | 0.821 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AS605240 | 3 | 72 | 0.32 | 3050.3 | 3575.0 | 586.9 | -0.495 | 0.882 | 0.853 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | PIK-93 | 3 | 72 | 0.01 | 3291.3 | 3394.0 | 586.9 | -2.0 | 0.976 | 0.970 | 2.532 | BT20 PIK93 0 3 |
| BT-20 | AS605240 | 3 | 72 | 0.1 | 3148.5 | 3575.0 | 586.9 | -1.0 | 0.905 | 0.881 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AS605240 | 3 | 72 | 0.032 | 3388.8 | 3575.0 | 586.9 | -1.49 | 0.959 | 0.948 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AS605240 | 3 | 72 | 0.01 | 3575.3 | 3575.0 | 586.9 | -2.0 | 1.000 | 1.000 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | PIK-93 | 3 | 72 | 1.0 | 2595.5 | 3394.0 | 586.9 | 0.0 | 0.799 | 0.765 | 2.532 | BT20 PIK93 0 3 |
| BT-20 | AS605240 | 3 | 72 | 0.0032 | 3254.5 | 3575.0 | 586.9 | -2.49 | 0.929 | 0.910 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | AS605240 | 3 | 72 | 0.001 | 3319.5 | 3575.0 | 586.9 | -3.0 | 0.944 | 0.929 | 2.607 | BT20 AS605240 0 3 |
| BT-20 | TGX221 | 3 | 72 | 0.1 | 3280.8 | 3248.8 | 586.9 | -1.0 | 1.010 | 1.010 | 2.469 | BT20 TGX221 0 3 |
| BT-20 | Torin1 | 3 | 72 | 0.032 | 1460.5 | 3483.3 | 586.9 | -1.49 | 0.426 | 0.419 | 2.569 | BT20 Torin1 0 3 |
| BT-20 | PIK-93 | 3 | 72 | 3.2 | 1424.3 | 3394.0 | 586.9 | 0.505 | 0.419 | 0.420 | 2.532 | BT20 PIK93 0 3 |
| BT-20 | Torin1 | 3 | 72 | 0.001 | 3206.0 | 3483.3 | 586.9 | -3.0 | 0.936 | 0.920 | 2.569 | BT20 Torin1 0 3 |
| BT-20 | TGX221 | 3 | 72 | 0.32 | 3331.5 | 3248.8 | 586.9 | -0.495 | 1.020 | 1.030 | 2.469 | BT20 TGX221 0 3 |
| BT-20 | TGX221 | 3 | 72 | 0.032 | 3002.3 | 3248.8 | 586.9 | -1.49 | 0.937 | 0.924 | 2.469 | BT20 TGX221 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 3.2 | 583.5 | 3579.5 | 586.9 | 0.505 | -0.002 | 0.163 | 2.609 | BT20 ZSTK474 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 1.0 | 982.5 | 3579.5 | 586.9 | 0.0 | 0.218 | 0.274 | 2.609 | BT20 ZSTK474 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 0.1 | 2816.5 | 3579.5 | 586.9 | -1.0 | 0.824 | 0.787 | 2.609 | BT20 ZSTK474 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 0.32 | 2178.5 | 3579.5 | 586.9 | -0.495 | 0.653 | 0.609 | 2.609 | BT20 ZSTK474 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 0.032 | 3138.0 | 3579.5 | 586.9 | -1.49 | 0.902 | 0.877 | 2.609 | BT20 ZSTK474 0 3 |
| BT-20 | XL147 | 3 | 72 | 3.2 | 2603.5 | 3677.3 | 586.9 | 0.505 | 0.755 | 0.708 | 2.647 | BT20 XL147 0 3 |
| BT-20 | ZSTK474 | 3 | 72 | 0.001 | 3277.0 | 3579.5 | 586.9 | -3.0 | 0.933 | 0.915 | 2.609 | BT20 ZSTK474 0 3 |