Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | Trametinib | 1 | 72 | 0.001 | 11633.3 | 11736.5 | 1742.8 | -3.0 | 0.994 | 0.991 | 2.751 | HCC1806 Trametinib 0 1 72 |
| HCC1806 | Trametinib | 1 | 72 | 0.0032 | 10675.8 | 11736.5 | 1742.8 | -2.49 | 0.932 | 0.910 | 2.751 | HCC1806 Trametinib 0 1 72 |
| HCC1806 | Trametinib | 1 | 72 | 0.01 | 10202.5 | 11736.5 | 1742.8 | -2.0 | 0.901 | 0.869 | 2.751 | HCC1806 Trametinib 0 1 72 |
| HCC1806 | Trametinib | 1 | 72 | 0.032 | 9495.0 | 11736.5 | 1742.8 | -1.49 | 0.852 | 0.809 | 2.751 | HCC1806 Trametinib 0 1 72 |
| HCC1806 | Trametinib | 1 | 72 | 0.1 | 9344.3 | 11736.5 | 1742.8 | -1.0 | 0.841 | 0.796 | 2.751 | HCC1806 Trametinib 0 1 72 |
| HCC1806 | Trametinib | 1 | 72 | 0.32 | 8807.3 | 11736.5 | 1742.8 | -0.495 | 0.802 | 0.750 | 2.751 | HCC1806 Trametinib 0 1 72 |
| HCC1806 | Trametinib | 1 | 72 | 1.0 | 8710.3 | 11736.5 | 1742.8 | 0.0 | 0.795 | 0.742 | 2.751 | HCC1806 Trametinib 0 1 72 |
| HCC1806 | Trametinib | 1 | 72 | 3.2 | 8956.8 | 11736.5 | 1742.8 | 0.505 | 0.813 | 0.763 | 2.751 | HCC1806 Trametinib 0 1 72 |
| HCC1806 | WYE-125132 | 1 | 72 | 0.001 | 11365.0 | 12050.8 | 1742.8 | -3.0 | 0.958 | 0.943 | 2.790 | HCC1806 WYE125132 0 1 72 |
| HCC1806 | WYE-125132 | 1 | 72 | 0.0032 | 11072.0 | 12050.8 | 1742.8 | -2.49 | 0.940 | 0.919 | 2.790 | HCC1806 WYE125132 0 1 72 |
| HCC1806 | WYE-125132 | 1 | 72 | 0.01 | 10352.8 | 12050.8 | 1742.8 | -2.0 | 0.894 | 0.859 | 2.790 | HCC1806 WYE125132 0 1 72 |
| HCC1806 | WYE-125132 | 1 | 72 | 0.032 | 8601.3 | 12050.8 | 1742.8 | -1.49 | 0.772 | 0.714 | 2.790 | HCC1806 WYE125132 0 1 72 |
| HCC1806 | WYE-125132 | 1 | 72 | 0.1 | 6801.8 | 12050.8 | 1742.8 | -1.0 | 0.629 | 0.564 | 2.790 | HCC1806 WYE125132 0 1 72 |
| HCC1806 | WYE-125132 | 1 | 72 | 0.32 | 5594.8 | 12050.8 | 1742.8 | -0.495 | 0.519 | 0.464 | 2.790 | HCC1806 WYE125132 0 1 72 |
| HCC1806 | WYE-125132 | 1 | 72 | 1.0 | 5290.0 | 12050.8 | 1742.8 | 0.0 | 0.489 | 0.439 | 2.790 | HCC1806 WYE125132 0 1 72 |
| HCC1806 | WYE-125132 | 1 | 72 | 3.2 | 5062.8 | 12050.8 | 1742.8 | 0.505 | 0.466 | 0.420 | 2.790 | HCC1806 WYE125132 0 1 72 |
| HCC1806 | XL147 | 1 | 72 | 0.001 | 11248.3 | 11581.0 | 1742.8 | -3.0 | 0.979 | 0.971 | 2.732 | HCC1806 XL147 0 1 72 |
| HCC1806 | XL147 | 1 | 72 | 0.0032 | 11345.3 | 11581.0 | 1742.8 | -2.49 | 0.985 | 0.980 | 2.732 | HCC1806 XL147 0 1 72 |
| HCC1806 | XL147 | 1 | 72 | 0.01 | 11593.8 | 11581.0 | 1742.8 | -2.0 | 1.000 | 1.000 | 2.732 | HCC1806 XL147 0 1 72 |
| HCC1806 | XL147 | 1 | 72 | 0.032 | 11500.3 | 11581.0 | 1742.8 | -1.49 | 0.995 | 0.993 | 2.732 | HCC1806 XL147 0 1 72 |
| HCC1806 | XL147 | 1 | 72 | 0.1 | 11258.8 | 11581.0 | 1742.8 | -1.0 | 0.979 | 0.972 | 2.732 | HCC1806 XL147 0 1 72 |
| HCC1806 | XL147 | 1 | 72 | 0.32 | 11645.5 | 11581.0 | 1742.8 | -0.495 | 1.000 | 1.010 | 2.732 | HCC1806 XL147 0 1 72 |
| HCC1806 | XL147 | 1 | 72 | 1.0 | 11919.8 | 11581.0 | 1742.8 | 0.0 | 1.020 | 1.030 | 2.732 | HCC1806 XL147 0 1 72 |
| HCC1806 | XL147 | 1 | 72 | 3.2 | 12161.5 | 11581.0 | 1742.8 | 0.505 | 1.040 | 1.050 | 2.732 | HCC1806 XL147 0 1 72 |
| HCC1806 | ZSTK474 | 1 | 72 | 0.001 | 11415.3 | 11395.8 | 1742.8 | -3.0 | 1.000 | 1.000 | 2.709 | HCC1806 ZSTK474 0 1 72 |