Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | Buparlisib | 3 | 72 | 1.0 | 1355.8 | 2804.3 | 517.3 | 0.0 | 0.485 | 0.483 | 2.439 | HCC70 BKM120 0 3 72 |
| HCC70 | Buparlisib | 3 | 72 | 0.01 | 2981.3 | 2804.3 | 517.3 | -2.0 | 1.050 | 1.060 | 2.439 | HCC70 BKM120 0 3 72 |
| HCC70 | Buparlisib | 3 | 72 | 0.032 | 2953.5 | 2804.3 | 517.3 | -1.49 | 1.040 | 1.050 | 2.439 | HCC70 BKM120 0 3 72 |
| HCC70 | Buparlisib | 3 | 72 | 0.0032 | 2878.0 | 2804.3 | 517.3 | -2.49 | 1.020 | 1.030 | 2.439 | HCC70 BKM120 0 3 72 |
| HCC70 | Buparlisib | 3 | 72 | 0.1 | 2648.0 | 2804.3 | 517.3 | -1.0 | 0.954 | 0.944 | 2.439 | HCC70 BKM120 0 3 72 |
| HCC70 | Buparlisib | 3 | 72 | 0.32 | 2363.0 | 2804.3 | 517.3 | -0.495 | 0.864 | 0.843 | 2.439 | HCC70 BKM120 0 3 72 |
| HCC70 | AZD8055 | 3 | 72 | 0.001 | 2586.0 | 2811.8 | 517.3 | -3.0 | 0.933 | 0.920 | 2.442 | HCC70 AZD8055 0 3 72 |
| HCC70 | AZD8055 | 3 | 72 | 3.2 | 1558.3 | 2811.8 | 517.3 | 0.505 | 0.571 | 0.554 | 2.442 | HCC70 AZD8055 0 3 72 |
| HCC70 | AZD8055 | 3 | 72 | 0.0032 | 2684.3 | 2811.8 | 517.3 | -2.49 | 0.962 | 0.955 | 2.442 | HCC70 AZD8055 0 3 72 |
| HCC70 | AZD8055 | 3 | 72 | 0.01 | 2231.8 | 2811.8 | 517.3 | -2.0 | 0.819 | 0.794 | 2.442 | HCC70 AZD8055 0 3 72 |
| HCC70 | AZD8055 | 3 | 72 | 0.032 | 1819.5 | 2811.8 | 517.3 | -1.49 | 0.674 | 0.647 | 2.442 | HCC70 AZD8055 0 3 72 |
| HCC70 | AZD8055 | 3 | 72 | 0.1 | 1703.5 | 2811.8 | 517.3 | -1.0 | 0.629 | 0.606 | 2.442 | HCC70 AZD8055 0 3 72 |
| HCC70 | AZD8055 | 3 | 72 | 0.32 | 1565.0 | 2811.8 | 517.3 | -0.495 | 0.573 | 0.557 | 2.442 | HCC70 AZD8055 0 3 72 |
| HCC70 | AZD8055 | 3 | 72 | 1.0 | 1584.0 | 2811.8 | 517.3 | 0.0 | 0.581 | 0.563 | 2.442 | HCC70 AZD8055 0 3 72 |
| HCC70 | PI103 | 3 | 72 | 0.0032 | 2870.3 | 2818.5 | 517.3 | -2.49 | 1.010 | 1.020 | 2.446 | HCC70 PI103 0 3 72 |
| HCC70 | PI103 | 3 | 72 | 0.1 | 2834.8 | 2818.5 | 517.3 | -1.0 | 1.000 | 1.010 | 2.446 | HCC70 PI103 0 3 72 |
| HCC70 | PI103 | 3 | 72 | 0.01 | 3081.3 | 2818.5 | 517.3 | -2.0 | 1.070 | 1.090 | 2.446 | HCC70 PI103 0 3 72 |
| HCC70 | PI103 | 3 | 72 | 0.32 | 2497.0 | 2818.5 | 517.3 | -0.495 | 0.903 | 0.886 | 2.446 | HCC70 PI103 0 3 72 |
| HCC70 | PI103 | 3 | 72 | 0.032 | 2948.8 | 2818.5 | 517.3 | -1.49 | 1.040 | 1.050 | 2.446 | HCC70 PI103 0 3 72 |
| HCC70 | PI103 | 3 | 72 | 1.0 | 1787.5 | 2818.5 | 517.3 | 0.0 | 0.660 | 0.634 | 2.446 | HCC70 PI103 0 3 72 |
| HCC70 | PI103 | 3 | 72 | 0.001 | 2860.5 | 2818.5 | 517.3 | -3.0 | 1.010 | 1.010 | 2.446 | HCC70 PI103 0 3 72 |
| HCC70 | PI103 | 3 | 72 | 3.2 | 854.0 | 2818.5 | 517.3 | 0.505 | 0.227 | 0.303 | 2.446 | HCC70 PI103 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 0.01 | 2809.8 | 2821.5 | 517.3 | -2.0 | 0.997 | 0.996 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 0.032 | 2913.0 | 2821.5 | 517.3 | -1.49 | 1.030 | 1.030 | 2.447 | HCC70 AS605240 0 3 72 |
| HCC70 | AS605240 | 3 | 72 | 0.1 | 2523.0 | 2821.5 | 517.3 | -1.0 | 0.911 | 0.894 | 2.447 | HCC70 AS605240 0 3 72 |