Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | GDC-0980 | 3 | 72 | 0.01 | 2932.8 | 2773.8 | 517.3 | -2.0 | 1.050 | 1.060 | 2.423 | HCC70 GDC0980 0 3 72 |
| HCC70 | GDC-0980 | 3 | 72 | 1.0 | 1244.3 | 2773.8 | 517.3 | 0.0 | 0.437 | 0.449 | 2.423 | HCC70 GDC0980 0 3 72 |
| HCC70 | GDC-0980 | 3 | 72 | 3.2 | 814.0 | 2773.8 | 517.3 | 0.505 | 0.206 | 0.293 | 2.423 | HCC70 GDC0980 0 3 72 |
| HCC70 | GDC-0980 | 3 | 72 | 0.1 | 2198.3 | 2773.8 | 517.3 | -1.0 | 0.817 | 0.793 | 2.423 | HCC70 GDC0980 0 3 72 |
| HCC70 | GDC-0980 | 3 | 72 | 0.001 | 2859.8 | 2773.8 | 517.3 | -3.0 | 1.030 | 1.030 | 2.423 | HCC70 GDC0980 0 3 72 |
| HCC70 | GDC-0980 | 3 | 72 | 0.0032 | 2881.5 | 2773.8 | 517.3 | -2.49 | 1.030 | 1.040 | 2.423 | HCC70 GDC0980 0 3 72 |
| HCC70 | GDC-0980 | 3 | 72 | 0.032 | 2619.5 | 2773.8 | 517.3 | -1.49 | 0.953 | 0.944 | 2.423 | HCC70 GDC0980 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 0.01 | 2073.0 | 2778.8 | 517.3 | -2.0 | 0.772 | 0.746 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 0.0032 | 2205.0 | 2778.8 | 517.3 | -2.49 | 0.818 | 0.794 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 0.001 | 2508.3 | 2778.8 | 517.3 | -3.0 | 0.917 | 0.903 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 0.1 | 1454.3 | 2778.8 | 517.3 | -1.0 | 0.531 | 0.523 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 0.32 | 641.0 | 2778.8 | 517.3 | -0.495 | 0.092 | 0.231 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 0.032 | 1853.5 | 2778.8 | 517.3 | -1.49 | 0.692 | 0.667 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 1.0 | 358.5 | 2778.8 | 517.3 | 0.0 | -0.140 | 0.129 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC70 | Torin2 | 3 | 72 | 3.2 | 160.0 | 2778.8 | 517.3 | 0.505 | -0.384 | 0.058 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC70 | Dactolisib | 3 | 72 | 3.2 | 1018.0 | 2787.8 | 517.3 | 0.505 | 0.321 | 0.365 | 2.430 | HCC70 BEZ235 0 3 72 |
| HCC70 | Dactolisib | 3 | 72 | 0.32 | 1708.0 | 2787.8 | 517.3 | -0.495 | 0.635 | 0.613 | 2.430 | HCC70 BEZ235 0 3 72 |
| HCC70 | Dactolisib | 3 | 72 | 0.1 | 1827.0 | 2787.8 | 517.3 | -1.0 | 0.681 | 0.655 | 2.430 | HCC70 BEZ235 0 3 72 |
| HCC70 | Dactolisib | 3 | 72 | 1.0 | 1287.8 | 2787.8 | 517.3 | 0.0 | 0.455 | 0.462 | 2.430 | HCC70 BEZ235 0 3 72 |
| HCC70 | Dactolisib | 3 | 72 | 0.001 | 2618.0 | 2787.8 | 517.3 | -3.0 | 0.949 | 0.939 | 2.430 | HCC70 BEZ235 0 3 72 |
| HCC70 | Dactolisib | 3 | 72 | 0.0032 | 2460.5 | 2787.8 | 517.3 | -2.49 | 0.900 | 0.883 | 2.430 | HCC70 BEZ235 0 3 72 |
| HCC70 | Dactolisib | 3 | 72 | 0.01 | 2127.5 | 2787.8 | 517.3 | -2.0 | 0.789 | 0.763 | 2.430 | HCC70 BEZ235 0 3 72 |
| HCC70 | Dactolisib | 3 | 72 | 0.032 | 1943.5 | 2787.8 | 517.3 | -1.49 | 0.724 | 0.697 | 2.430 | HCC70 BEZ235 0 3 72 |
| HCC70 | Buparlisib | 3 | 72 | 3.2 | 341.8 | 2804.3 | 517.3 | 0.505 | -0.156 | 0.122 | 2.439 | HCC70 BKM120 0 3 72 |
| HCC70 | Buparlisib | 3 | 72 | 1.0 | 1355.8 | 2804.3 | 517.3 | 0.0 | 0.485 | 0.483 | 2.439 | HCC70 BKM120 0 3 72 |