Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | Torin2 | 1 | 72 | 1.0 | 457.3 | 5846.0 | 1443.3 | 0.0 | -0.434 | 0.078 | 2.018 | BT20 Torin2 0 1 |
| Hs 578T | Omipalisib | 1 | 72 | 1.0 | 465.3 | 3689.5 | 873.1 | 0.0 | -0.261 | 0.126 | 2.079 | Hs578T GSK458 1 |
| BT-20 | Torin2 | 2 | 72 | 1.0 | 466.8 | 3386.5 | 1018.6 | 0.0 | -0.362 | 0.138 | 1.733 | BT20 Torin2 0 2 |
| Hs 578T | Torin2 | 1 | 72 | 1.0 | 467.0 | 3568.0 | 873.1 | 0.0 | -0.265 | 0.131 | 2.031 | Hs578T Torin2 1 |
| BT-20 | Omipalisib | 3 | 72 | 0.32 | 473.0 | 3523.0 | 586.9 | -0.495 | -0.080 | 0.134 | 2.586 | BT20 GSK458 0 3 |
| HCC70 | Torin2 | 2 | 72 | 1.0 | 483.8 | 2562.3 | 722.8 | 0.0 | -0.197 | 0.189 | 1.826 | HCC70 Torin2 0 2 72 |
| HCC1806 | Buparlisib | 2 | 72 | 3.2 | 493.8 | 11660.8 | 1643.3 | 0.505 | -0.346 | 0.042 | 2.827 | HCC1806 BKM120 0 2 72 |
| HCC1806 | Buparlisib | 1 | 72 | 3.2 | 493.8 | 11660.8 | 1742.8 | 0.505 | -0.369 | 0.042 | 2.742 | HCC1806 BKM120 0 1 72 |
| HCC1806 | Buparlisib | 3 | 72 | 3.2 | 493.8 | 11660.8 | 1273.3 | 0.505 | -0.257 | 0.042 | 3.195 | HCC1806 BKM120 0 3 72 |
| BT-20 | Buparlisib | 1 | 72 | 3.2 | 495.8 | 6321.8 | 1443.3 | 0.505 | -0.394 | 0.078 | 2.131 | BT20 BKM120 0 1 |
| HCC70 | Buparlisib | 1 | 72 | 3.2 | 501.8 | 3318.0 | 1279.8 | 0.505 | -0.494 | 0.151 | 1.374 | HCC70 BKM120 0 1 72 |
| HCC38 | BX-912 | 3 | 72 | 1.0 | 524.3 | 3233.3 | 1180.5 | 0.0 | -0.428 | 0.162 | 1.454 | HCC38 BX912 0 3 72 |
| HCC38 | Torin2 | 2 | 72 | 0.32 | 524.3 | 3044.5 | 690.5 | -0.495 | -0.121 | 0.172 | 2.140 | HCC38 Torin2 0 2 72 |
| HCC70 | Torin2 | 1 | 72 | 1.0 | 526.5 | 3294.3 | 1279.8 | 0.0 | -0.479 | 0.160 | 1.364 | HCC70 Torin2 0 1 72 |
| BT-20 | AZD8055 | 3 | 72 | 3.2 | 529.0 | 3441.0 | 586.9 | 0.505 | -0.040 | 0.154 | 2.552 | BT20 AZD8055 0 3 |
| Hs 578T | Dactolisib | 2 | 72 | 3.2 | 532.5 | 3555.0 | 624.7 | 0.505 | -0.062 | 0.150 | 2.509 | Hs578T BEZ235 2 |
| HCC38 | Omipalisib | 2 | 72 | 1.0 | 538.3 | 3009.3 | 690.5 | 0.0 | -0.111 | 0.179 | 2.124 | HCC38 GSK458 0 2 72 |
| HCC70 | Omipalisib | 1 | 72 | 0.1 | 538.5 | 3280.0 | 1279.8 | -1.0 | -0.471 | 0.164 | 1.358 | HCC70 GSK458 0 1 72 |
| Hs 578T | GDC-0980 | 2 | 72 | 3.2 | 540.5 | 3584.0 | 624.7 | 0.505 | -0.056 | 0.151 | 2.520 | Hs578T GDC0980 2 |
| BT-549 | Buparlisib | 3 | 72 | 3.2 | 540.8 | 4081.3 | 1175.8 | 0.505 | -0.351 | 0.132 | 1.795 | BT549 BKM120 0 3 72 |
| BT-20 | Omipalisib | 2 | 72 | 0.32 | 541.3 | 3349.0 | 1018.6 | -0.495 | -0.308 | 0.162 | 1.717 | BT20 GSK458 0 2 |
| HCC70 | Omipalisib | 3 | 72 | 0.1 | 554.0 | 2841.5 | 517.3 | -1.0 | 0.028 | 0.195 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC38 | BX-912 | 3 | 72 | 3.2 | 555.8 | 3233.3 | 1180.5 | 0.505 | -0.404 | 0.172 | 1.454 | HCC38 BX912 0 3 72 |
| Hs 578T | BX-912 | 1 | 72 | 3.2 | 555.8 | 3493.8 | 873.1 | 0.505 | -0.202 | 0.159 | 2.001 | Hs578T BX912 1 |
| Hs 578T | Torin2 | 2 | 72 | 0.32 | 563.0 | 3604.3 | 624.7 | -0.495 | -0.040 | 0.156 | 2.528 | Hs578T Torin2 2 |