Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | WYE-125132 | 2 | 72 | 0.32 | 1007.0 | 3642.3 | 624.7 | -0.495 | 0.206 | 0.276 | 2.544 | Hs578T WYE125132 2 |
| BT-549 | Torin2 | 1 | 72 | 3.2 | 1007.0 | 5306.0 | 1554.9 | 0.505 | -0.218 | 0.190 | 1.771 | BT549 Torin2 0 1 72 |
| HCC38 | Dactolisib | 2 | 72 | 0.1 | 1009.5 | 3001.5 | 690.5 | -1.0 | 0.196 | 0.336 | 2.120 | HCC38 BEZ235 0 2 72 |
| BT-20 | Dactolisib | 2 | 72 | 0.032 | 1014.0 | 3372.5 | 1018.6 | -1.49 | -0.003 | 0.301 | 1.727 | BT20 BEZ235 0 2 |
| HCC70 | Dactolisib | 3 | 72 | 3.2 | 1018.0 | 2787.8 | 517.3 | 0.505 | 0.321 | 0.365 | 2.430 | HCC70 BEZ235 0 3 72 |
| BT-20 | MK2206 | 3 | 72 | 3.2 | 1018.5 | 3205.3 | 586.9 | 0.505 | 0.252 | 0.318 | 2.449 | BT20 MK2206 0 3 |
| Hs 578T | WYE-125132 | 1 | 72 | 3.2 | 1021.0 | 3529.8 | 873.1 | 0.505 | 0.081 | 0.289 | 2.015 | Hs578T WYE125132 1 |
| Hs 578T | GDC-0980 | 1 | 72 | 1.0 | 1032.0 | 3454.8 | 873.1 | 0.0 | 0.088 | 0.299 | 1.984 | Hs578T GDC0980 1 |
| Hs 578T | Torin1 | 3 | 72 | 0.32 | 1032.5 | 4147.8 | 571.3 | -0.495 | 0.230 | 0.249 | 2.860 | Hs578T Torin1 3 |
| HCC70 | Dactolisib | 2 | 72 | 3.2 | 1033.3 | 2310.8 | 722.8 | 0.505 | 0.238 | 0.447 | 1.677 | HCC70 BEZ235 0 2 72 |
| BT-20 | Torin2 | 3 | 72 | 0.032 | 1034.3 | 3225.3 | 586.9 | -1.49 | 0.259 | 0.321 | 2.458 | BT20 Torin2 0 3 |
| Hs 578T | AZD8055 | 3 | 72 | 1.0 | 1042.3 | 4224.8 | 571.3 | 0.0 | 0.232 | 0.247 | 2.886 | Hs578T AZD8055 3 |
| BT-549 | Omipalisib | 1 | 72 | 3.2 | 1043.3 | 5372.5 | 1554.9 | 0.505 | -0.200 | 0.194 | 1.789 | BT549 GSK458 0 1 72 |
| HCC70 | GDC-0980 | 2 | 72 | 1.0 | 1043.3 | 2310.0 | 722.8 | 0.0 | 0.245 | 0.452 | 1.676 | HCC70 GDC0980 0 2 72 |
| Hs 578T | AZD8055 | 2 | 72 | 0.32 | 1043.8 | 3486.0 | 624.7 | -0.495 | 0.230 | 0.299 | 2.480 | Hs578T AZD8055 2 |
| Hs 578T | Dactolisib | 3 | 72 | 0.32 | 1044.0 | 4081.0 | 571.3 | -0.495 | 0.237 | 0.256 | 2.837 | Hs578T BEZ235 3 |
| BT-549 | Omipalisib | 2 | 72 | 1.0 | 1045.3 | 4963.8 | 1249.6 | 0.0 | -0.086 | 0.211 | 1.990 | BT549 GSK458 0 2 72 |
| HCC70 | MK2206 | 2 | 72 | 3.2 | 1045.5 | 2332.3 | 722.8 | 0.505 | 0.244 | 0.448 | 1.690 | HCC70 MK2206 0 2 72 |
| BT-20 | ZSTK474 | 2 | 72 | 1.0 | 1046.8 | 3516.3 | 1018.6 | 0.0 | 0.015 | 0.298 | 1.787 | BT20 ZSTK474 0 2 |
| Hs 578T | WYE-125132 | 3 | 72 | 1.0 | 1048.5 | 4195.3 | 571.3 | 0.0 | 0.235 | 0.250 | 2.876 | Hs578T WYE125132 3 |
| BT-20 | AZD8055 | 3 | 72 | 0.1 | 1053.0 | 3441.0 | 586.9 | -1.0 | 0.257 | 0.306 | 2.552 | BT20 AZD8055 0 3 |
| Hs 578T | Dactolisib | 2 | 72 | 0.1 | 1055.0 | 3555.0 | 624.7 | -1.0 | 0.232 | 0.297 | 2.509 | Hs578T BEZ235 2 |
| Hs 578T | AZD8055 | 1 | 72 | 1.0 | 1056.5 | 3514.5 | 873.1 | 0.0 | 0.100 | 0.301 | 2.009 | Hs578T AZD8055 1 |
| HCC38 | PI103 | 2 | 72 | 3.2 | 1058.8 | 2947.5 | 690.5 | 0.505 | 0.226 | 0.359 | 2.094 | HCC38 PI103 0 2 72 |
| HCC38 | Omipalisib | 1 | 72 | 1.0 | 1059.3 | 4389.3 | 1295.5 | 0.0 | -0.108 | 0.241 | 1.760 | HCC38 GSK458 0 1 72 |