Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | Torin2 | 2 | 72 | 3.2 | 127.3 | 3604.3 | 624.7 | 0.505 | -0.467 | 0.035 | 2.528 | Hs578T Torin2 2 |
| BT-20 | Buparlisib | 2 | 72 | 3.2 | 359.5 | 3408.8 | 1018.6 | 0.505 | -0.450 | 0.105 | 1.743 | BT20 BKM120 0 2 |
| BT-20 | Torin2 | 1 | 72 | 1.0 | 457.3 | 5846.0 | 1443.3 | 0.0 | -0.434 | 0.078 | 2.018 | BT20 Torin2 0 1 |
| HCC70 | Omipalisib | 2 | 72 | 0.32 | 281.3 | 2319.3 | 722.8 | -0.495 | -0.429 | 0.121 | 1.682 | HCC70 GSK458 0 2 72 |
| HCC38 | BX-912 | 3 | 72 | 1.0 | 524.3 | 3233.3 | 1180.5 | 0.0 | -0.428 | 0.162 | 1.454 | HCC38 BX912 0 3 72 |
| Hs 578T | Buparlisib | 3 | 72 | 3.2 | 115.3 | 4235.0 | 571.3 | 0.505 | -0.425 | 0.027 | 2.890 | Hs578T BKM120 3 |
| Hs 578T | Buparlisib | 2 | 72 | 3.2 | 158.8 | 3566.8 | 624.7 | 0.505 | -0.420 | 0.045 | 2.513 | Hs578T BKM120 2 |
| HCC38 | Torin2 | 3 | 72 | 1.0 | 563.3 | 3083.5 | 1180.5 | 0.0 | -0.414 | 0.183 | 1.385 | HCC38 Torin2 0 3 72 |
| BT-20 | GDC-0980 | 2 | 72 | 3.2 | 420.0 | 3217.8 | 1018.6 | 0.505 | -0.414 | 0.131 | 1.659 | BT20 GDC0980 0 2 |
| BT-20 | Omipalisib | 3 | 72 | 1.0 | 151.5 | 3523.0 | 586.9 | 0.0 | -0.408 | 0.043 | 2.586 | BT20 GSK458 0 3 |
| Hs 578T | Torin2 | 1 | 72 | 3.2 | 303.8 | 3568.0 | 873.1 | 0.505 | -0.405 | 0.085 | 2.031 | Hs578T Torin2 1 |
| HCC70 | Omipalisib | 3 | 72 | 3.2 | 145.0 | 2841.5 | 517.3 | 0.505 | -0.404 | 0.051 | 2.458 | HCC70 GSK458 0 3 72 |
| HCC38 | BX-912 | 3 | 72 | 3.2 | 555.8 | 3233.3 | 1180.5 | 0.505 | -0.404 | 0.172 | 1.454 | HCC38 BX912 0 3 72 |
| BT-20 | AZD8055 | 2 | 72 | 3.2 | 419.0 | 3421.5 | 1018.6 | 0.505 | -0.398 | 0.122 | 1.748 | BT20 AZD8055 0 2 |
| BT-20 | Buparlisib | 1 | 72 | 3.2 | 495.8 | 6321.8 | 1443.3 | 0.505 | -0.394 | 0.078 | 2.131 | BT20 BKM120 0 1 |
| HCC70 | Torin2 | 3 | 72 | 3.2 | 160.0 | 2778.8 | 517.3 | 0.505 | -0.384 | 0.058 | 2.425 | HCC70 Torin2 0 3 72 |
| HCC38 | Buparlisib | 3 | 72 | 3.2 | 599.0 | 3184.0 | 1180.5 | 0.505 | -0.377 | 0.188 | 1.431 | HCC38 BKM120 0 3 72 |
| HCC1806 | Buparlisib | 1 | 72 | 3.2 | 493.8 | 11660.8 | 1742.8 | 0.505 | -0.369 | 0.042 | 2.742 | HCC1806 BKM120 0 1 72 |
| BT-20 | Torin2 | 2 | 72 | 1.0 | 466.8 | 3386.5 | 1018.6 | 0.0 | -0.362 | 0.138 | 1.733 | BT20 Torin2 0 2 |
| BT-549 | Buparlisib | 3 | 72 | 3.2 | 540.8 | 4081.3 | 1175.8 | 0.505 | -0.351 | 0.132 | 1.795 | BT549 BKM120 0 3 72 |
| Hs 578T | Torin2 | 2 | 72 | 1.0 | 212.3 | 3604.3 | 624.7 | 0.0 | -0.347 | 0.059 | 2.528 | Hs578T Torin2 2 |
| HCC1806 | Buparlisib | 2 | 72 | 3.2 | 493.8 | 11660.8 | 1643.3 | 0.505 | -0.346 | 0.042 | 2.827 | HCC1806 BKM120 0 2 72 |
| HCC38 | Omipalisib | 3 | 72 | 1.0 | 651.5 | 3215.3 | 1180.5 | 0.0 | -0.337 | 0.203 | 1.446 | HCC38 GSK458 0 3 72 |
| HCC1806 | Omipalisib | 1 | 72 | 3.2 | 569.3 | 11840.0 | 1742.8 | 0.505 | -0.333 | 0.048 | 2.764 | HCC1806 GSK458 0 1 72 |
| HCC38 | Torin2 | 2 | 72 | 1.0 | 295.3 | 3044.5 | 690.5 | 0.0 | -0.328 | 0.097 | 2.140 | HCC38 Torin2 0 2 72 |