Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. - Dataset (ID:20364)
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| Cell line | Drug name | Experimental replicate | Timepoint | Drug concentration | Live cell count | Average live cell count, DMSO control | Average live cell count (time = 0) | Log10(drug concentration) | GR value | Relative cell count (treatment versus DMSO) | Cell doublings (DMSO control) | Experiment name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | XL147 | 2 | 72 | 1.0 | 11919.8 | 11581.0 | 1643.3 | 0.0 | 1.020 | 1.030 | 2.817 | HCC1806 XL147 0 2 72 |
| HCC38 | AS605240 | 1 | 72 | 0.001 | 4413.5 | 4340.3 | 1295.5 | -3.0 | 1.020 | 1.020 | 1.744 | HCC38 AS605240 0 1 72 |
| BT-549 | Pictilisib | 1 | 72 | 0.01 | 5399.3 | 5311.0 | 1554.9 | -2.0 | 1.020 | 1.020 | 1.772 | BT549 GDC0941 0 1 72 |
| HCC38 | AZD-6482 | 1 | 72 | 0.01 | 4371.8 | 4304.5 | 1295.5 | -2.0 | 1.020 | 1.020 | 1.732 | HCC38 AZD6482 0 1 72 |
| HCC1806 | TGX221 | 2 | 72 | 3.2 | 11540.3 | 11158.5 | 1643.3 | 0.505 | 1.020 | 1.030 | 2.763 | HCC1806 TGX221 0 2 72 |
| HCC1806 | TGX221 | 2 | 72 | 0.32 | 11531.3 | 11158.5 | 1643.3 | -0.495 | 1.020 | 1.030 | 2.763 | HCC1806 TGX221 0 2 72 |
| HCC1806 | TGX221 | 2 | 72 | 0.1 | 11446.3 | 11158.5 | 1643.3 | -1.0 | 1.020 | 1.030 | 2.763 | HCC1806 TGX221 0 2 72 |
| HCC1806 | TGX221 | 2 | 72 | 0.032 | 11433.8 | 11158.5 | 1643.3 | -1.49 | 1.020 | 1.020 | 2.763 | HCC1806 TGX221 0 2 72 |
| HCC1806 | KIN001-244 | 2 | 72 | 0.001 | 11912.3 | 11660.3 | 1643.3 | -3.0 | 1.020 | 1.020 | 2.827 | HCC1806 KIN001-244 0 2 72 |
| HCC38 | CAL-101 | 1 | 72 | 0.0032 | 4366.5 | 4275.5 | 1295.5 | -2.49 | 1.020 | 1.020 | 1.723 | HCC38 CAL101 0 1 72 |
| HCC38 | CAL-101 | 1 | 72 | 0.032 | 4361.3 | 4275.5 | 1295.5 | -1.49 | 1.020 | 1.020 | 1.723 | HCC38 CAL101 0 1 72 |
| HCC38 | Pictilisib | 1 | 72 | 0.001 | 4454.8 | 4386.3 | 1295.5 | -3.0 | 1.020 | 1.020 | 1.759 | HCC38 GDC0941 0 1 72 |
| HCC1806 | CAL-101 | 2 | 72 | 1.0 | 11624.3 | 11282.8 | 1643.3 | 0.0 | 1.020 | 1.030 | 2.779 | HCC1806 CAL101 0 2 72 |
| HCC38 | KIN001-244 | 1 | 72 | 0.01 | 4429.3 | 4361.0 | 1295.5 | -2.0 | 1.020 | 1.020 | 1.751 | HCC38 KIN001-244 0 1 72 |
| HCC1806 | AZD-6482 | 2 | 72 | 3.2 | 11967.3 | 11709.8 | 1643.3 | 0.505 | 1.020 | 1.020 | 2.833 | HCC1806 AZD6482 0 2 72 |
| HCC1806 | AZD-6482 | 2 | 72 | 0.1 | 12053.8 | 11709.8 | 1643.3 | -1.0 | 1.020 | 1.030 | 2.833 | HCC1806 AZD6482 0 2 72 |
| HCC1806 | AS605240 | 2 | 72 | 0.032 | 11947.8 | 11546.3 | 1643.3 | -1.49 | 1.020 | 1.030 | 2.813 | HCC1806 AS605240 0 2 72 |
| HCC1806 | ZSTK474 | 1 | 72 | 0.01 | 11648.8 | 11395.8 | 1742.8 | -2.0 | 1.020 | 1.020 | 2.709 | HCC1806 ZSTK474 0 1 72 |
| HCC1806 | XL147 | 1 | 72 | 1.0 | 11919.8 | 11581.0 | 1742.8 | 0.0 | 1.020 | 1.030 | 2.732 | HCC1806 XL147 0 1 72 |
| HCC38 | TGX221 | 1 | 72 | 0.0032 | 4362.0 | 4281.3 | 1295.5 | -2.49 | 1.020 | 1.020 | 1.724 | HCC38 TGX221 0 1 72 |
| HCC38 | TGX221 | 1 | 72 | 0.01 | 4351.0 | 4281.3 | 1295.5 | -2.0 | 1.020 | 1.020 | 1.724 | HCC38 TGX221 0 1 72 |
| HCC1806 | TGX221 | 1 | 72 | 0.32 | 11531.3 | 11158.5 | 1742.8 | -0.495 | 1.020 | 1.030 | 2.679 | HCC1806 TGX221 0 1 72 |
| HCC1806 | TGX221 | 1 | 72 | 0.1 | 11446.3 | 11158.5 | 1742.8 | -1.0 | 1.020 | 1.030 | 2.679 | HCC1806 TGX221 0 1 72 |
| BT-20 | TGX221 | 3 | 72 | 0.32 | 3331.5 | 3248.8 | 586.9 | -0.495 | 1.020 | 1.030 | 2.469 | BT20 TGX221 0 3 |
| HCC1806 | TGX221 | 1 | 72 | 0.032 | 11433.8 | 11158.5 | 1742.8 | -1.49 | 1.020 | 1.020 | 2.679 | HCC1806 TGX221 0 1 72 |